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Pulmonary Embolism Associated With Protein C Deficiency and Abuse of Anabolic-androgen Steroids

Alhadad, Alaa LU ; Acosta, Stefan LU ; Sarabi, Latif and Kölbel, Tilo LU (2010) In Clinical and Applied Thrombosis/Hemostasis 16(2). p.228-231
Abstract
We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids. Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency. Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin. The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Applied Thrombosis/Hemostasis
volume
16
issue
2
pages
228 - 231
publisher
SAGE Publications Inc.
external identifiers
  • wos:000275738500019
  • scopus:77949876536
ISSN
1938-2723
DOI
10.1177/1076029608324930
language
English
LU publication?
yes
id
23f18d70-d799-4c82-b1fe-4ee419966642 (old id 1588099)
date added to LUP
2010-04-22 10:57:48
date last changed
2018-05-29 10:19:25
@article{23f18d70-d799-4c82-b1fe-4ee419966642,
  abstract     = {We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids. Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency. Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin. The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.},
  author       = {Alhadad, Alaa and Acosta, Stefan and Sarabi, Latif and Kölbel, Tilo},
  issn         = {1938-2723},
  language     = {eng},
  number       = {2},
  pages        = {228--231},
  publisher    = {SAGE Publications Inc.},
  series       = {Clinical and Applied Thrombosis/Hemostasis},
  title        = {Pulmonary Embolism Associated With Protein C Deficiency and Abuse of Anabolic-androgen Steroids},
  url          = {http://dx.doi.org/10.1177/1076029608324930},
  volume       = {16},
  year         = {2010},
}