Advanced

Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging

Jarnum, Hanna; Steffensen, Elena G.; Knutsson, Linda LU ; Frund, Ernst-Torben; Simonsen, Carsten Wiberg; Lundbye-Christensen, Soren; Shankaranarayanan, Ajit; Alsop, David C.; Jensen, Finn Taagehoj and Larsson, Elna-Marie (2010) In Neuroradiology 52(4). p.307-317
Abstract
The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no... (More)
The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no susceptibility artefacts and 2 = extensive susceptibility artefacts (maximum diameter > 2 cm)). A quantitative analysis was performed with normalised tumour blood flow values (ASL nTBF, DSC nTBF): mean value for region of interest (ROI) in an area with maximum signal enhancement/the mean value for ROIs in cerebellum. There was no difference in total visual score for signal enhancement between PC ASL and DSC relative cerebral blood flow (p = 0.12). ASL had a lower susceptibility-artefact score than DSC-MRI (p = 0.03). There was good correlation between DSC nTBF and ASL nTBF values with a correlation coefficient of 0.82. PC ASL is an alternative to DSC-MRI for the evaluation of perfusion in brain tumours. The method has fewer susceptibility artefacts than DSC-MRI and can be used in patients with renal failure because no contrast injection is needed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain neoplasms, DSC-MRI, ASL, Magnetic resonance imaging, Perfusion
in
Neuroradiology
volume
52
issue
4
pages
307 - 317
publisher
Springer Verlag
external identifiers
  • wos:000275422000006
  • scopus:77953049771
ISSN
1432-1920
DOI
10.1007/s00234-009-0616-6
language
English
LU publication?
yes
id
9a152d45-0b9e-4326-99c4-3b7ff458ba85 (old id 1588235)
date added to LUP
2010-04-22 10:22:29
date last changed
2018-07-01 03:22:25
@article{9a152d45-0b9e-4326-99c4-3b7ff458ba85,
  abstract     = {The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no susceptibility artefacts and 2 = extensive susceptibility artefacts (maximum diameter > 2 cm)). A quantitative analysis was performed with normalised tumour blood flow values (ASL nTBF, DSC nTBF): mean value for region of interest (ROI) in an area with maximum signal enhancement/the mean value for ROIs in cerebellum. There was no difference in total visual score for signal enhancement between PC ASL and DSC relative cerebral blood flow (p = 0.12). ASL had a lower susceptibility-artefact score than DSC-MRI (p = 0.03). There was good correlation between DSC nTBF and ASL nTBF values with a correlation coefficient of 0.82. PC ASL is an alternative to DSC-MRI for the evaluation of perfusion in brain tumours. The method has fewer susceptibility artefacts than DSC-MRI and can be used in patients with renal failure because no contrast injection is needed.},
  author       = {Jarnum, Hanna and Steffensen, Elena G. and Knutsson, Linda and Frund, Ernst-Torben and Simonsen, Carsten Wiberg and Lundbye-Christensen, Soren and Shankaranarayanan, Ajit and Alsop, David C. and Jensen, Finn Taagehoj and Larsson, Elna-Marie},
  issn         = {1432-1920},
  keyword      = {Brain neoplasms,DSC-MRI,ASL,Magnetic resonance imaging,Perfusion},
  language     = {eng},
  number       = {4},
  pages        = {307--317},
  publisher    = {Springer Verlag},
  series       = {Neuroradiology},
  title        = {Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging},
  url          = {http://dx.doi.org/10.1007/s00234-009-0616-6},
  volume       = {52},
  year         = {2010},
}