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Low expression of CysLT(1)R and high expression of CysLT(2)R mediate good prognosis in colorectal cancer

Magnusson, Cecilia LU ; Mezhybovska, Maryna LU ; Lörinc, Ester LU ; Fernebro, Eva LU ; Nilbert, Mef LU and Sjölander, Anita LU (2010) In European Journal of Cancer 46(4). p.826-835
Abstract
Colorectal cancer is the third most common cancer type in the western world. in search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT(1)R, and cell differentiation via the CysLT(2)R. These results prompted us to investigate the significance of CysLT(1)R and CysLT(2)R expression in colorectal cancer tissue for patient survival. The CysLT(1)R, CysLT(2)R, beta-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT(1)R is associated with a poor prognosis, whereas high... (More)
Colorectal cancer is the third most common cancer type in the western world. in search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT(1)R, and cell differentiation via the CysLT(2)R. These results prompted us to investigate the significance of CysLT(1)R and CysLT(2)R expression in colorectal cancer tissue for patient survival. The CysLT(1)R, CysLT(2)R, beta-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT(1)R is associated with a poor prognosis, whereas high nuclear expression of CysLT(2)R is associated with a good prognosis. We also observed that patients with colorectal tumours characterised by high CysLT(1)R but low CysLT(2)R nuclear expression had the lowest survival expectancy, whereas patients with colorectal tumours characterised by low CysLT(1)R but high CysLT(2)R nuclear expression had the best survival expectancy. Interestingly, beta-catenin as a single prognostic marker did not exhibit any prognostic value. However, in patients with tumours characterised by a high CysLT(1)R nuclear expression, an elevated beta-catenin nuclear expression had a significantly prognostic value. In conclusion these data indicate that nuclear expressions of CysLTRs are potential prognostic indicators of colorectal cancer. (C) 2009 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colorectal cancer, beta-Catenin, CysLT(1)R, CysLT(2)R
in
European Journal of Cancer
volume
46
issue
4
pages
826 - 835
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000275594500028
  • scopus:76049111365
ISSN
1879-0852
DOI
10.1016/j.ejca.2009.12.022
language
English
LU publication?
yes
id
6e574d14-80b4-4c7d-a375-cdc90727d864 (old id 1589039)
date added to LUP
2010-04-20 14:17:33
date last changed
2018-05-29 10:59:05
@article{6e574d14-80b4-4c7d-a375-cdc90727d864,
  abstract     = {Colorectal cancer is the third most common cancer type in the western world. in search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT(1)R, and cell differentiation via the CysLT(2)R. These results prompted us to investigate the significance of CysLT(1)R and CysLT(2)R expression in colorectal cancer tissue for patient survival. The CysLT(1)R, CysLT(2)R, beta-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT(1)R is associated with a poor prognosis, whereas high nuclear expression of CysLT(2)R is associated with a good prognosis. We also observed that patients with colorectal tumours characterised by high CysLT(1)R but low CysLT(2)R nuclear expression had the lowest survival expectancy, whereas patients with colorectal tumours characterised by low CysLT(1)R but high CysLT(2)R nuclear expression had the best survival expectancy. Interestingly, beta-catenin as a single prognostic marker did not exhibit any prognostic value. However, in patients with tumours characterised by a high CysLT(1)R nuclear expression, an elevated beta-catenin nuclear expression had a significantly prognostic value. In conclusion these data indicate that nuclear expressions of CysLTRs are potential prognostic indicators of colorectal cancer. (C) 2009 Elsevier Ltd. All rights reserved.},
  author       = {Magnusson, Cecilia and Mezhybovska, Maryna and Lörinc, Ester and Fernebro, Eva and Nilbert, Mef and Sjölander, Anita},
  issn         = {1879-0852},
  keyword      = {Colorectal cancer,beta-Catenin,CysLT(1)R,CysLT(2)R},
  language     = {eng},
  number       = {4},
  pages        = {826--835},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Low expression of CysLT(1)R and high expression of CysLT(2)R mediate good prognosis in colorectal cancer},
  url          = {http://dx.doi.org/10.1016/j.ejca.2009.12.022},
  volume       = {46},
  year         = {2010},
}