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Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus

Hanly, J. G.; Urowitz, M. B.; Su, L.; Bae, S. C.; Gordon, C.; Wallace, D. J.; Clarke, A.; Bernatsky, S.; Isenberg, D. and Rahman, A., et al. (2010) In Annals of the Rheumatic Diseases 69(3). p.529-535
Abstract
Objectives To determine the frequency, accrual, attribution and outcome of neuropsychiatric (NP) events and impact on quality of life over 3 years in a large inception cohort of patients with systemic lupus erythematosus (SLE). Methods The study was conducted by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis. NP events were identified using the American College of Rheumatology case definitions, and decision rules were derived to determine the proportion of NP disease attributable to SLE. The outcome of NP events was recorded and patient-perceived impact determined by the SF-36. Results 1206 patients (89.6% female) with a mean (+/- SD) age of 34.5 +/- 13.2 years were included... (More)
Objectives To determine the frequency, accrual, attribution and outcome of neuropsychiatric (NP) events and impact on quality of life over 3 years in a large inception cohort of patients with systemic lupus erythematosus (SLE). Methods The study was conducted by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis. NP events were identified using the American College of Rheumatology case definitions, and decision rules were derived to determine the proportion of NP disease attributable to SLE. The outcome of NP events was recorded and patient-perceived impact determined by the SF-36. Results 1206 patients (89.6% female) with a mean (+/- SD) age of 34.5 +/- 13.2 years were included in the study. The mean disease duration at enrolment was 5.4 +/- 4.2 months. Over a mean follow-up of 1.9 +/- 1.2 years, 486/1206 (40.3%) patients had >= 1 NP events, which were attributed to SLE in 13.0-23.6% of patients using two a priori decision rules. The frequency of individual NP events varied from 47.1% (headache) to 0% (myasthenia gravis). The outcome was significantly better for those NP events attributed to SLE, especially if they occurred within 1.5 years of the diagnosis of SLE. Patients with NP events, regardless of attribution, had significantly lower summary scores for both mental and physical health over the study. Conclusions NP events in patients with SLE are of variable frequency, most commonly present early in the disease course and adversely impact patients' quality of life over time. Events attributed to non-SLE causes are more common than those due to SLE, although the latter have a more favourable outcome. (Less)
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Annals of the Rheumatic Diseases
volume
69
issue
3
pages
529 - 535
publisher
British Medical Association
external identifiers
  • wos:000275458700010
  • scopus:77949438167
ISSN
1468-2060
DOI
10.1136/ard.2008.106351
language
English
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yes
id
1d72609b-5e7d-45e1-b135-0b1dd1dad19b (old id 1589224)
date added to LUP
2010-04-20 13:14:24
date last changed
2018-07-08 03:39:12
@article{1d72609b-5e7d-45e1-b135-0b1dd1dad19b,
  abstract     = {Objectives To determine the frequency, accrual, attribution and outcome of neuropsychiatric (NP) events and impact on quality of life over 3 years in a large inception cohort of patients with systemic lupus erythematosus (SLE). Methods The study was conducted by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis. NP events were identified using the American College of Rheumatology case definitions, and decision rules were derived to determine the proportion of NP disease attributable to SLE. The outcome of NP events was recorded and patient-perceived impact determined by the SF-36. Results 1206 patients (89.6% female) with a mean (+/- SD) age of 34.5 +/- 13.2 years were included in the study. The mean disease duration at enrolment was 5.4 +/- 4.2 months. Over a mean follow-up of 1.9 +/- 1.2 years, 486/1206 (40.3%) patients had >= 1 NP events, which were attributed to SLE in 13.0-23.6% of patients using two a priori decision rules. The frequency of individual NP events varied from 47.1% (headache) to 0% (myasthenia gravis). The outcome was significantly better for those NP events attributed to SLE, especially if they occurred within 1.5 years of the diagnosis of SLE. Patients with NP events, regardless of attribution, had significantly lower summary scores for both mental and physical health over the study. Conclusions NP events in patients with SLE are of variable frequency, most commonly present early in the disease course and adversely impact patients' quality of life over time. Events attributed to non-SLE causes are more common than those due to SLE, although the latter have a more favourable outcome.},
  author       = {Hanly, J. G. and Urowitz, M. B. and Su, L. and Bae, S. C. and Gordon, C. and Wallace, D. J. and Clarke, A. and Bernatsky, S. and Isenberg, D. and Rahman, A. and Alarcon, G. S. and Gladman, D. D. and Fortin, P. R. and Sanchez-Guerrero, J. and Romero-Diaz, J. and Merrill, J. T. and Ginzler, E. and Bruce, I. N. and Steinsson, K. and Khamashta, M. and Petri, M. and Manzi, S. and Dooley, M. A. and Ramsey-Goldman, R. and Van Vollenhoven, R. and Nived, Ola and Sturfelt, Gunnar and Aranow, C. and Kalunian, K. and Ramos-Casals, M. and Zoma, A. and Douglas, J. and Thompson, K. and Farewell, V.},
  issn         = {1468-2060},
  language     = {eng},
  number       = {3},
  pages        = {529--535},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1136/ard.2008.106351},
  volume       = {69},
  year         = {2010},
}