Advanced

Fifteen-Piconewton Force Detection from Neural Growth Cones Using Nanowire Arrays

Hällström, Waldemar LU ; Lexholm, Monica LU ; Suyatin, Dmitry LU ; Hammarin, Greger; Hessman, Dan LU ; Samuelson, Lars LU ; Montelius, Lars LU ; Kanje, Martin LU and Prinz, Christelle LU (2010) In Nano Letters 10(3). p.782-787
Abstract
We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mu m. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy, Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the Fine details of growth-cone dynamics.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neuron, nanowire, picoNewton, Mechanosensing, cellular force
in
Nano Letters
volume
10
issue
3
pages
782 - 787
publisher
The American Chemical Society
external identifiers
  • wos:000275278200006
  • scopus:77949469188
ISSN
1530-6992
DOI
10.1021/nl902675h
language
English
LU publication?
yes
id
924ac828-aeac-48ab-9cfa-afcd5c5a7895 (old id 1589418)
date added to LUP
2010-04-20 11:22:53
date last changed
2018-07-15 03:46:31
@article{924ac828-aeac-48ab-9cfa-afcd5c5a7895,
  abstract     = {We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mu m. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy, Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the Fine details of growth-cone dynamics.},
  author       = {Hällström, Waldemar and Lexholm, Monica and Suyatin, Dmitry and Hammarin, Greger and Hessman, Dan and Samuelson, Lars and Montelius, Lars and Kanje, Martin and Prinz, Christelle},
  issn         = {1530-6992},
  keyword      = {neuron,nanowire,picoNewton,Mechanosensing,cellular force},
  language     = {eng},
  number       = {3},
  pages        = {782--787},
  publisher    = {The American Chemical Society},
  series       = {Nano Letters},
  title        = {Fifteen-Piconewton Force Detection from Neural Growth Cones Using Nanowire Arrays},
  url          = {http://dx.doi.org/10.1021/nl902675h},
  volume       = {10},
  year         = {2010},
}