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Does low molecular weight heparin shorten term labor?

Ekman-Ordeberg, Gunvor; Akerud, Anna; Dubicke, Aurelija; Malmström, Anders LU and Hellgren, Margareta (2010) In Acta Obstetricia et Gynecologica Scandinavica 89(1). p.147-150
Abstract
Dalteparin, a low molecular weight heparin (LMWH), is given to pregnant women with thrombotic disorders. Clinical observations together with the documented changes of heparan sulfate proteoglycans in normal and protracted labor fostered the idea that LMWH shortens delivery time. Labor time was retrospectively determined among nulliparous pregnant women treated with dalteparin because of previous venous thromboembolism (VTE), thrombophilia or acute VTE during current pregnancy. Their labor time was compared to matched untreated controls. The proportion of instrumental deliveries and neonatal outcome was also compared. The dalteparin-treated group showed a significantly (30%) shorter labor time compared to matched controls. Total... (More)
Dalteparin, a low molecular weight heparin (LMWH), is given to pregnant women with thrombotic disorders. Clinical observations together with the documented changes of heparan sulfate proteoglycans in normal and protracted labor fostered the idea that LMWH shortens delivery time. Labor time was retrospectively determined among nulliparous pregnant women treated with dalteparin because of previous venous thromboembolism (VTE), thrombophilia or acute VTE during current pregnancy. Their labor time was compared to matched untreated controls. The proportion of instrumental deliveries and neonatal outcome was also compared. The dalteparin-treated group showed a significantly (30%) shorter labor time compared to matched controls. Total instrumental deliveries were the same in the two groups but operative intervention due to protracted labor was significantly less common in dalteparin-treated women. There was no difference in neonatal outcome. Dalteparin most likely shortens parturition time and may decrease the number of operative interventions due to protracted labor. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
protracted labor, Dalteparin, delivery time
in
Acta Obstetricia et Gynecologica Scandinavica
volume
89
issue
1
pages
147 - 150
publisher
Wiley-Blackwell
external identifiers
  • wos:000275251200024
  • scopus:74049132676
ISSN
1600-0412
DOI
10.3109/00016340903294272
language
English
LU publication?
yes
id
b13c54b3-a6ec-4080-9825-4cacef9ca9d4 (old id 1589842)
date added to LUP
2010-04-19 14:35:56
date last changed
2018-06-24 04:23:26
@article{b13c54b3-a6ec-4080-9825-4cacef9ca9d4,
  abstract     = {Dalteparin, a low molecular weight heparin (LMWH), is given to pregnant women with thrombotic disorders. Clinical observations together with the documented changes of heparan sulfate proteoglycans in normal and protracted labor fostered the idea that LMWH shortens delivery time. Labor time was retrospectively determined among nulliparous pregnant women treated with dalteparin because of previous venous thromboembolism (VTE), thrombophilia or acute VTE during current pregnancy. Their labor time was compared to matched untreated controls. The proportion of instrumental deliveries and neonatal outcome was also compared. The dalteparin-treated group showed a significantly (30%) shorter labor time compared to matched controls. Total instrumental deliveries were the same in the two groups but operative intervention due to protracted labor was significantly less common in dalteparin-treated women. There was no difference in neonatal outcome. Dalteparin most likely shortens parturition time and may decrease the number of operative interventions due to protracted labor.},
  author       = {Ekman-Ordeberg, Gunvor and Akerud, Anna and Dubicke, Aurelija and Malmström, Anders and Hellgren, Margareta},
  issn         = {1600-0412},
  keyword      = {protracted labor,Dalteparin,delivery time},
  language     = {eng},
  number       = {1},
  pages        = {147--150},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Does low molecular weight heparin shorten term labor?},
  url          = {http://dx.doi.org/10.3109/00016340903294272},
  volume       = {89},
  year         = {2010},
}