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Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation.

Edsjö, Anders LU ; Holmquist Mengelbier, Linda LU and Påhlman, Sven LU (2007) In Seminars in Cancer Biology 17(3). p.248-256
Abstract
Neuroblastoma is a childhood tumor derived from precursor or immature cells of the sympathetic nervous system. Neuroblastomas show a tremendous clinical heterogeneity, encompassing truly benign as well as extremely aggressive forms. In vivo as well as in vitro data have shown that the degree of sympathetic neuronal tumor cell differentiation influences patient outcome. Unraveling mechanisms governing neuroblastoma cell differentiation is therefore a central issue in the neuroblastoma research field. In this communication, we discuss some of the in vitro models frequently used to study human neuroblastoma cell differentiation. We also review recent data demonstrating that oxygen shortage, hypoxia, shifts neuroblastoma cells toward an... (More)
Neuroblastoma is a childhood tumor derived from precursor or immature cells of the sympathetic nervous system. Neuroblastomas show a tremendous clinical heterogeneity, encompassing truly benign as well as extremely aggressive forms. In vivo as well as in vitro data have shown that the degree of sympathetic neuronal tumor cell differentiation influences patient outcome. Unraveling mechanisms governing neuroblastoma cell differentiation is therefore a central issue in the neuroblastoma research field. In this communication, we discuss some of the in vitro models frequently used to study human neuroblastoma cell differentiation. We also review recent data demonstrating that oxygen shortage, hypoxia, shifts neuroblastoma cells toward an immature, stem cell-like phenotype and discuss the potential clinical impact of hypoxia on neuroblastoma behavior. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neuroblastoma, hypoxia, sympathetic nervous, neuronal differentiation, system
in
Seminars in Cancer Biology
volume
17
issue
3
pages
248 - 256
publisher
Academic Press
external identifiers
  • wos:000246860300009
  • scopus:33947138135
ISSN
1096-3650
DOI
10.1016/j.semcancer.2006.04.005
language
English
LU publication?
yes
id
ab56c19f-e2d1-4618-86a6-442cdeee9d47 (old id 159109)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16828305&dopt=Abstract
date added to LUP
2007-07-24 14:50:14
date last changed
2017-11-19 04:10:09
@article{ab56c19f-e2d1-4618-86a6-442cdeee9d47,
  abstract     = {Neuroblastoma is a childhood tumor derived from precursor or immature cells of the sympathetic nervous system. Neuroblastomas show a tremendous clinical heterogeneity, encompassing truly benign as well as extremely aggressive forms. In vivo as well as in vitro data have shown that the degree of sympathetic neuronal tumor cell differentiation influences patient outcome. Unraveling mechanisms governing neuroblastoma cell differentiation is therefore a central issue in the neuroblastoma research field. In this communication, we discuss some of the in vitro models frequently used to study human neuroblastoma cell differentiation. We also review recent data demonstrating that oxygen shortage, hypoxia, shifts neuroblastoma cells toward an immature, stem cell-like phenotype and discuss the potential clinical impact of hypoxia on neuroblastoma behavior.},
  author       = {Edsjö, Anders and Holmquist Mengelbier, Linda and Påhlman, Sven},
  issn         = {1096-3650},
  keyword      = {neuroblastoma,hypoxia,sympathetic nervous,neuronal differentiation,system},
  language     = {eng},
  number       = {3},
  pages        = {248--256},
  publisher    = {Academic Press},
  series       = {Seminars in Cancer Biology},
  title        = {Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation.},
  url          = {http://dx.doi.org/10.1016/j.semcancer.2006.04.005},
  volume       = {17},
  year         = {2007},
}