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Major histocompatibility alleles associated with local resistance to malaria in a passerine

Bonneaud, C ; Perez-Tris, Javier LU ; Federici, P ; Chastel, O and Sorci, G (2006) In Evolution 60(2). p.383-389
Abstract
Malaria parasites are a major cause of human mortality in tropical countries and a potential threat for wildlife, as witnessed by the malaria-induced extinction of naive Hawaiian avifauna. Identifying resistance mechanisms is therefore crucial both for human health and wildlife conservation. Patterns of malaria resistance are known to be highly polygenic in both humans and mice, with marked contributions attributed to major histocompatibility (Mhc) genes. Here we show that specific Mhc variants are linked to both increased resistance and susceptibility to malaria infection in a wild passerine species, the house sparrow (Passer domesticus). In addition, links between host immunogenctics and resistance to malaria involved population-specific... (More)
Malaria parasites are a major cause of human mortality in tropical countries and a potential threat for wildlife, as witnessed by the malaria-induced extinction of naive Hawaiian avifauna. Identifying resistance mechanisms is therefore crucial both for human health and wildlife conservation. Patterns of malaria resistance are known to be highly polygenic in both humans and mice, with marked contributions attributed to major histocompatibility (Mhc) genes. Here we show that specific Mhc variants are linked to both increased resistance and susceptibility to malaria infection in a wild passerine species, the house sparrow (Passer domesticus). In addition, links between host immunogenctics and resistance to malaria involved population-specific alleles, suggesting local adaptation in this host-parasite interaction. This is the first evidence for a population-specific genetic control of resistance to malaria in a wild species. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Evolution
volume
60
issue
2
pages
383 - 389
publisher
Wiley-Blackwell
external identifiers
  • pmid:16610328
  • wos:000236383200015
  • scopus:33646831806
ISSN
1558-5646
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Animal Ecology (Closed 2011) (011012001)
id
e5ccff17-c7d1-4ed8-8825-e02462334cf4 (old id 159410)
alternative location
http://www.bioone.org/archive/0014-3820/60/2/pdf/i0014-3820-60-2-383.pdf
date added to LUP
2016-04-01 17:08:11
date last changed
2021-09-22 04:09:29
@article{e5ccff17-c7d1-4ed8-8825-e02462334cf4,
  abstract     = {Malaria parasites are a major cause of human mortality in tropical countries and a potential threat for wildlife, as witnessed by the malaria-induced extinction of naive Hawaiian avifauna. Identifying resistance mechanisms is therefore crucial both for human health and wildlife conservation. Patterns of malaria resistance are known to be highly polygenic in both humans and mice, with marked contributions attributed to major histocompatibility (Mhc) genes. Here we show that specific Mhc variants are linked to both increased resistance and susceptibility to malaria infection in a wild passerine species, the house sparrow (Passer domesticus). In addition, links between host immunogenctics and resistance to malaria involved population-specific alleles, suggesting local adaptation in this host-parasite interaction. This is the first evidence for a population-specific genetic control of resistance to malaria in a wild species.},
  author       = {Bonneaud, C and Perez-Tris, Javier and Federici, P and Chastel, O and Sorci, G},
  issn         = {1558-5646},
  language     = {eng},
  number       = {2},
  pages        = {383--389},
  publisher    = {Wiley-Blackwell},
  series       = {Evolution},
  title        = {Major histocompatibility alleles associated with local resistance to malaria in a passerine},
  url          = {http://www.bioone.org/archive/0014-3820/60/2/pdf/i0014-3820-60-2-383.pdf},
  volume       = {60},
  year         = {2006},
}