Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia.
(2010) In Clinical Biochemistry May 4. p.873-876- Abstract
- INTRODUCTION: Critical limb ischemia (CLI) is a severe peripheral arterial disease, characterized by rest pain, ulcers and gangrene in the legs. Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl. Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation. DESIGN AND METHODS: We quantified plasma concentrations of Gas6 and sAxl in 189 CLI patients and 204 controls. RESULTS: Gas6 and sAxl concentrations were increased in the CLI patients (p<0.0001) and correlated to C-reactive protein, interleukin-6, tumor necrosis factor alpha and neopterin. Patients who died within three... (More)
- INTRODUCTION: Critical limb ischemia (CLI) is a severe peripheral arterial disease, characterized by rest pain, ulcers and gangrene in the legs. Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl. Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation. DESIGN AND METHODS: We quantified plasma concentrations of Gas6 and sAxl in 189 CLI patients and 204 controls. RESULTS: Gas6 and sAxl concentrations were increased in the CLI patients (p<0.0001) and correlated to C-reactive protein, interleukin-6, tumor necrosis factor alpha and neopterin. Patients who died within three years of sampling (n=84) had increased concentrations of Gas6 and sAxl as compared to survivors (p=0.0009 and p=0.0011). CONCLUSIONS: Plasma concentrations of Gas6 and sAxl correlate to inflammation and predict survival. This indicates that Gas6 and sAxl have a role in CLI, presumably connected to the inflammatory process. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1594825
- author
- Ekman, Carl LU ; Gottsäter, Anders LU ; Lindblad, Bengt LU and Dahlbäck, Björn LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Biochemistry
- volume
- May 4
- pages
- 873 - 876
- publisher
- Elsevier
- external identifiers
-
- wos:000279133100013
- pmid:20417630
- scopus:77953725800
- pmid:20417630
- ISSN
- 1873-2933
- DOI
- 10.1016/j.clinbiochem.2010.04.006
- language
- English
- LU publication?
- yes
- id
- f8094426-8d5d-4882-90ba-011c7f89532e (old id 1594825)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20417630?dopt=Abstract
- date added to LUP
- 2016-04-04 07:40:29
- date last changed
- 2022-01-29 02:27:27
@article{f8094426-8d5d-4882-90ba-011c7f89532e, abstract = {{INTRODUCTION: Critical limb ischemia (CLI) is a severe peripheral arterial disease, characterized by rest pain, ulcers and gangrene in the legs. Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl. Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation. DESIGN AND METHODS: We quantified plasma concentrations of Gas6 and sAxl in 189 CLI patients and 204 controls. RESULTS: Gas6 and sAxl concentrations were increased in the CLI patients (p<0.0001) and correlated to C-reactive protein, interleukin-6, tumor necrosis factor alpha and neopterin. Patients who died within three years of sampling (n=84) had increased concentrations of Gas6 and sAxl as compared to survivors (p=0.0009 and p=0.0011). CONCLUSIONS: Plasma concentrations of Gas6 and sAxl correlate to inflammation and predict survival. This indicates that Gas6 and sAxl have a role in CLI, presumably connected to the inflammatory process.}}, author = {{Ekman, Carl and Gottsäter, Anders and Lindblad, Bengt and Dahlbäck, Björn}}, issn = {{1873-2933}}, language = {{eng}}, pages = {{873--876}}, publisher = {{Elsevier}}, series = {{Clinical Biochemistry}}, title = {{Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia.}}, url = {{http://dx.doi.org/10.1016/j.clinbiochem.2010.04.006}}, doi = {{10.1016/j.clinbiochem.2010.04.006}}, volume = {{May 4}}, year = {{2010}}, }