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Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia.

Ekman, Carl LU ; Gottsäter, Anders LU ; Lindblad, Bengt LU and Dahlbäck, Björn LU (2010) In Clinical Biochemistry May 4. p.873-876
Abstract
INTRODUCTION: Critical limb ischemia (CLI) is a severe peripheral arterial disease, characterized by rest pain, ulcers and gangrene in the legs. Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl. Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation. DESIGN AND METHODS: We quantified plasma concentrations of Gas6 and sAxl in 189 CLI patients and 204 controls. RESULTS: Gas6 and sAxl concentrations were increased in the CLI patients (p<0.0001) and correlated to C-reactive protein, interleukin-6, tumor necrosis factor alpha and neopterin. Patients who died within three... (More)
INTRODUCTION: Critical limb ischemia (CLI) is a severe peripheral arterial disease, characterized by rest pain, ulcers and gangrene in the legs. Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl. Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation. DESIGN AND METHODS: We quantified plasma concentrations of Gas6 and sAxl in 189 CLI patients and 204 controls. RESULTS: Gas6 and sAxl concentrations were increased in the CLI patients (p<0.0001) and correlated to C-reactive protein, interleukin-6, tumor necrosis factor alpha and neopterin. Patients who died within three years of sampling (n=84) had increased concentrations of Gas6 and sAxl as compared to survivors (p=0.0009 and p=0.0011). CONCLUSIONS: Plasma concentrations of Gas6 and sAxl correlate to inflammation and predict survival. This indicates that Gas6 and sAxl have a role in CLI, presumably connected to the inflammatory process. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Biochemistry
volume
May 4
pages
873 - 876
publisher
Elsevier
external identifiers
  • wos:000279133100013
  • pmid:20417630
  • scopus:77953725800
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2010.04.006
language
English
LU publication?
yes
id
f8094426-8d5d-4882-90ba-011c7f89532e (old id 1594825)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20417630?dopt=Abstract
date added to LUP
2010-05-04 23:03:52
date last changed
2018-05-29 10:09:57
@article{f8094426-8d5d-4882-90ba-011c7f89532e,
  abstract     = {INTRODUCTION: Critical limb ischemia (CLI) is a severe peripheral arterial disease, characterized by rest pain, ulcers and gangrene in the legs. Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl. Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation. DESIGN AND METHODS: We quantified plasma concentrations of Gas6 and sAxl in 189 CLI patients and 204 controls. RESULTS: Gas6 and sAxl concentrations were increased in the CLI patients (p&lt;0.0001) and correlated to C-reactive protein, interleukin-6, tumor necrosis factor alpha and neopterin. Patients who died within three years of sampling (n=84) had increased concentrations of Gas6 and sAxl as compared to survivors (p=0.0009 and p=0.0011). CONCLUSIONS: Plasma concentrations of Gas6 and sAxl correlate to inflammation and predict survival. This indicates that Gas6 and sAxl have a role in CLI, presumably connected to the inflammatory process.},
  author       = {Ekman, Carl and Gottsäter, Anders and Lindblad, Bengt and Dahlbäck, Björn},
  issn         = {1873-2933},
  language     = {eng},
  pages        = {873--876},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia.},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2010.04.006},
  volume       = {May 4},
  year         = {2010},
}