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Vasomotor symptoms, estradiol levels and cardiovascular risk profile in women.

Gast, Gerrie-Cor M; Samsioe, Göran LU ; Grobbee, Diederick E; Nilsson, Peter LU and van der Schouw, Yvonne T (2010) In Maturitas Mar 4. p.285-290
Abstract
OBJECTIVES: We investigated whether menopausal vasomotor symptoms (VMS) are related to an adverse cardiovascular risk profile. Furthermore, we examined the association between estradiol levels and VMS, and whether an association between VMS and cardiovascular risk factors can be explained by estradiol levels. STUDY DESIGN: We used data from a Swedish population-based sample of 5857 women, aged 50-64 years. Data on VMS and potential confounders were collected by questionnaires. MAIN OUTCOME MEASURES: Body mass index (BMI), waist hip ratio (WHR), glucose, blood pressure, lipid profile and estradiol levels were measured. RESULTS: Symptoms of flushing/sweats were reported by 55% and sweats by 31% of all women. Estradiol concentrations were... (More)
OBJECTIVES: We investigated whether menopausal vasomotor symptoms (VMS) are related to an adverse cardiovascular risk profile. Furthermore, we examined the association between estradiol levels and VMS, and whether an association between VMS and cardiovascular risk factors can be explained by estradiol levels. STUDY DESIGN: We used data from a Swedish population-based sample of 5857 women, aged 50-64 years. Data on VMS and potential confounders were collected by questionnaires. MAIN OUTCOME MEASURES: Body mass index (BMI), waist hip ratio (WHR), glucose, blood pressure, lipid profile and estradiol levels were measured. RESULTS: Symptoms of flushing/sweats were reported by 55% and sweats by 31% of all women. Estradiol concentrations were significantly lower in women with VMS. After multivariate adjustment, women with symptoms of sweats had a statistically significantly higher BMI, waist hip ratio, total cholesterol level, LDL level, triglycerides level, glucose level, systolic and diastolic blood pressure. These patterns did not change after correction for estradiol. The associations between flushing/sweats combined and cardiovascular risk factors were less pronounced. CONCLUSIONS: Women with VMS have a less favorable cardiovascular risk profile. Although estradiol levels were significantly lower among women with VMS, the increased cardiovascular risk profile cannot be explained by circulating estradiol levels. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Maturitas
volume
Mar 4
pages
285 - 290
publisher
Elsevier
external identifiers
  • wos:000279981200012
  • pmid:20400247
  • scopus:77953027484
ISSN
1873-4111
DOI
10.1016/j.maturitas.2010.03.015
language
English
LU publication?
yes
id
b591036c-21e2-49cd-928b-169b224cd6b7 (old id 1595122)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20400247?dopt=Abstract
date added to LUP
2010-05-04 16:59:09
date last changed
2018-06-17 04:58:00
@article{b591036c-21e2-49cd-928b-169b224cd6b7,
  abstract     = {OBJECTIVES: We investigated whether menopausal vasomotor symptoms (VMS) are related to an adverse cardiovascular risk profile. Furthermore, we examined the association between estradiol levels and VMS, and whether an association between VMS and cardiovascular risk factors can be explained by estradiol levels. STUDY DESIGN: We used data from a Swedish population-based sample of 5857 women, aged 50-64 years. Data on VMS and potential confounders were collected by questionnaires. MAIN OUTCOME MEASURES: Body mass index (BMI), waist hip ratio (WHR), glucose, blood pressure, lipid profile and estradiol levels were measured. RESULTS: Symptoms of flushing/sweats were reported by 55% and sweats by 31% of all women. Estradiol concentrations were significantly lower in women with VMS. After multivariate adjustment, women with symptoms of sweats had a statistically significantly higher BMI, waist hip ratio, total cholesterol level, LDL level, triglycerides level, glucose level, systolic and diastolic blood pressure. These patterns did not change after correction for estradiol. The associations between flushing/sweats combined and cardiovascular risk factors were less pronounced. CONCLUSIONS: Women with VMS have a less favorable cardiovascular risk profile. Although estradiol levels were significantly lower among women with VMS, the increased cardiovascular risk profile cannot be explained by circulating estradiol levels.},
  author       = {Gast, Gerrie-Cor M and Samsioe, Göran and Grobbee, Diederick E and Nilsson, Peter and van der Schouw, Yvonne T},
  issn         = {1873-4111},
  language     = {eng},
  pages        = {285--290},
  publisher    = {Elsevier},
  series       = {Maturitas},
  title        = {Vasomotor symptoms, estradiol levels and cardiovascular risk profile in women.},
  url          = {http://dx.doi.org/10.1016/j.maturitas.2010.03.015},
  volume       = {Mar 4},
  year         = {2010},
}