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Antiproliferative effects of curcuphenol, a sesquiterpene phenol.

Rodrigo, Gloria LU ; Almanza, Geovanna; Cheng, Yajun LU ; Peng, Jiangnan; Hamann, Mark; Duan, Rui-Dong LU and Åkesson, Björn LU (2010) In Fitoterapia 81(7). p.762-766
Abstract
Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116microg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cell proliferation, Curcuphenol, Apoptosis, Caspase
in
Fitoterapia
volume
81
issue
7
pages
762 - 766
publisher
Elsevier
external identifiers
  • wos:000282864800012
  • pmid:20385210
  • scopus:77956674196
ISSN
1873-6971
DOI
10.1016/j.fitote.2010.04.001
language
English
LU publication?
yes
id
b001e344-3681-4a2f-84ff-bad2e88a8d4d (old id 1595323)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20385210?dopt=Abstract
date added to LUP
2010-05-04 22:34:52
date last changed
2018-05-29 11:56:33
@article{b001e344-3681-4a2f-84ff-bad2e88a8d4d,
  abstract     = {Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116microg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.},
  author       = {Rodrigo, Gloria and Almanza, Geovanna and Cheng, Yajun and Peng, Jiangnan and Hamann, Mark and Duan, Rui-Dong and Åkesson, Björn},
  issn         = {1873-6971},
  keyword      = {Cell proliferation,Curcuphenol,Apoptosis,Caspase},
  language     = {eng},
  number       = {7},
  pages        = {762--766},
  publisher    = {Elsevier},
  series       = {Fitoterapia},
  title        = {Antiproliferative effects of curcuphenol, a sesquiterpene phenol.},
  url          = {http://dx.doi.org/10.1016/j.fitote.2010.04.001},
  volume       = {81},
  year         = {2010},
}