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Antiproliferative effects of curcuphenol, a sesquiterpene phenol.

Rodrigo, Gloria LU ; Almanza, Geovanna ; Cheng, Yajun LU ; Peng, Jiangnan ; Hamann, Mark ; Duan, Rui-Dong LU and Åkesson, Björn LU (2010) In Fitoterapia 81(7). p.762-766
Abstract
Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116microg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cell proliferation, Curcuphenol, Apoptosis, Caspase
in
Fitoterapia
volume
81
issue
7
pages
762 - 766
publisher
Elsevier
external identifiers
  • wos:000282864800012
  • pmid:20385210
  • scopus:77956674196
  • pmid:20385210
ISSN
1873-6971
DOI
10.1016/j.fitote.2010.04.001
language
English
LU publication?
yes
id
b001e344-3681-4a2f-84ff-bad2e88a8d4d (old id 1595323)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20385210?dopt=Abstract
date added to LUP
2016-04-01 14:57:05
date last changed
2024-11-08 02:41:02
@article{b001e344-3681-4a2f-84ff-bad2e88a8d4d,
  abstract     = {{Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116microg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.}},
  author       = {{Rodrigo, Gloria and Almanza, Geovanna and Cheng, Yajun and Peng, Jiangnan and Hamann, Mark and Duan, Rui-Dong and Åkesson, Björn}},
  issn         = {{1873-6971}},
  keywords     = {{Cell proliferation; Curcuphenol; Apoptosis; Caspase}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{762--766}},
  publisher    = {{Elsevier}},
  series       = {{Fitoterapia}},
  title        = {{Antiproliferative effects of curcuphenol, a sesquiterpene phenol.}},
  url          = {{http://dx.doi.org/10.1016/j.fitote.2010.04.001}},
  doi          = {{10.1016/j.fitote.2010.04.001}},
  volume       = {{81}},
  year         = {{2010}},
}