Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms.
(2010) In Vascular and Endovascular Surgery 44(4). p.262-268- Abstract
- We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients. Results: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than... (More)
- We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients. Results: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than controls. Matrix metalloproteinase 2 correlated inversely and APC-PCI complex correlated directly with AAA diameter. We found no correlations between markers for proteolysis, fibrinolysis, coagulation, and yearly AAA growth. CONCLUSION: Matrix metalloproteinase 2 is lower and APC-PCI higher in patients with larger AAA, but the relevance of the markers for AAA growth is far from clarified. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1598730
- author
- Flondell-Sité, Despina LU ; Lindblad, Bengt LU ; Kölbel, Tilo LU and Gottsäter, Anders LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal/blood, Biomarkers/blood, Blood Coagulation, Case-Control Studies, Disease Progression, Female, Fibrinolysis, Follow-Up Studies, Humans, Male, Matrix Metalloproteinase 2/blood, Matrix Metalloproteinase 9/blood, Middle Aged, Peptide Hydrolases/blood, Plasminogen Activator Inhibitor 1/blood, Prospective Studies, Protein C/metabolism, Protein C Inhibitor/blood, Sweden, Time Factors, Tissue Inhibitor of Metalloproteinase-1/blood, Tissue Plasminogen Activator/blood
- in
- Vascular and Endovascular Surgery
- volume
- 44
- issue
- 4
- pages
- 7 pages
- publisher
- SAGE Publications
- external identifiers
-
- wos:000276803500004
- pmid:20356864
- scopus:77951757326
- pmid:20356864
- ISSN
- 1938-9116
- DOI
- 10.1177/1538574410361971
- language
- English
- LU publication?
- yes
- id
- 0e3a31c0-e3c2-4c1d-be1f-55f2d0d96d04 (old id 1598730)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20356864?dopt=Abstract
- date added to LUP
- 2016-04-04 08:41:04
- date last changed
- 2024-02-12 08:17:17
@article{0e3a31c0-e3c2-4c1d-be1f-55f2d0d96d04, abstract = {{We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients. Results: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than controls. Matrix metalloproteinase 2 correlated inversely and APC-PCI complex correlated directly with AAA diameter. We found no correlations between markers for proteolysis, fibrinolysis, coagulation, and yearly AAA growth. CONCLUSION: Matrix metalloproteinase 2 is lower and APC-PCI higher in patients with larger AAA, but the relevance of the markers for AAA growth is far from clarified.}}, author = {{Flondell-Sité, Despina and Lindblad, Bengt and Kölbel, Tilo and Gottsäter, Anders}}, issn = {{1938-9116}}, keywords = {{Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal/blood; Biomarkers/blood; Blood Coagulation; Case-Control Studies; Disease Progression; Female; Fibrinolysis; Follow-Up Studies; Humans; Male; Matrix Metalloproteinase 2/blood; Matrix Metalloproteinase 9/blood; Middle Aged; Peptide Hydrolases/blood; Plasminogen Activator Inhibitor 1/blood; Prospective Studies; Protein C/metabolism; Protein C Inhibitor/blood; Sweden; Time Factors; Tissue Inhibitor of Metalloproteinase-1/blood; Tissue Plasminogen Activator/blood}}, language = {{eng}}, number = {{4}}, pages = {{262--268}}, publisher = {{SAGE Publications}}, series = {{Vascular and Endovascular Surgery}}, title = {{Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms.}}, url = {{http://dx.doi.org/10.1177/1538574410361971}}, doi = {{10.1177/1538574410361971}}, volume = {{44}}, year = {{2010}}, }