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Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms.

Flondell-Sité, Despina LU ; Lindblad, Bengt LU ; Kölbel, Tilo LU and Gottsäter, Anders LU (2010) In Vascular and Endovascular Surgery 44(4). p.262-268
Abstract
We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients. Results: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than... (More)
We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients. Results: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than controls. Matrix metalloproteinase 2 correlated inversely and APC-PCI complex correlated directly with AAA diameter. We found no correlations between markers for proteolysis, fibrinolysis, coagulation, and yearly AAA growth. CONCLUSION: Matrix metalloproteinase 2 is lower and APC-PCI higher in patients with larger AAA, but the relevance of the markers for AAA growth is far from clarified. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Vascular and Endovascular Surgery
volume
44
issue
4
pages
262 - 268
publisher
SAGE Publications Inc.
external identifiers
  • wos:000276803500004
  • pmid:20356864
  • scopus:77951757326
ISSN
1938-9116
DOI
10.1177/1538574410361971
language
English
LU publication?
yes
id
0e3a31c0-e3c2-4c1d-be1f-55f2d0d96d04 (old id 1598730)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20356864?dopt=Abstract
date added to LUP
2010-05-03 14:56:01
date last changed
2018-05-29 11:09:52
@article{0e3a31c0-e3c2-4c1d-be1f-55f2d0d96d04,
  abstract     = {We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analyzed in 353 patients with AAA grouped according to AAA size, and 219 gender- and age-matched healthy individuals. Follow-up of AAA growth for up to 7 years was possible in 178 of 353 patients. Results: At baseline, all groups of patients with AAA showed lower levels of MMP-2 and -9, and higher levels of TIMP-1, serpine-1, and t-Pa-serpine-1 than controls. Matrix metalloproteinase 2 correlated inversely and APC-PCI complex correlated directly with AAA diameter. We found no correlations between markers for proteolysis, fibrinolysis, coagulation, and yearly AAA growth. CONCLUSION: Matrix metalloproteinase 2 is lower and APC-PCI higher in patients with larger AAA, but the relevance of the markers for AAA growth is far from clarified.},
  author       = {Flondell-Sité, Despina and Lindblad, Bengt and Kölbel, Tilo and Gottsäter, Anders},
  issn         = {1938-9116},
  language     = {eng},
  number       = {4},
  pages        = {262--268},
  publisher    = {SAGE Publications Inc.},
  series       = {Vascular and Endovascular Surgery},
  title        = {Markers of proteolysis, fibrinolysis, and coagulation in relation to size and growth rate of abdominal aortic aneurysms.},
  url          = {http://dx.doi.org/10.1177/1538574410361971},
  volume       = {44},
  year         = {2010},
}