The problem of confounding in studies of the effect of maternal drug use on pregnancy outcome.
(2012) In Obstetrics and Gynecology International 2012.- Abstract
- In most epidemilogical studies, the problem of confounding adds to the uncertainty in conclusions drawn. This is also true for studies on the effect of maternal drug use on birth defect risks. This paper describes various types of such confounders and discusses methods to identify and adjust for them. Such confounders can be found in maternal characteristics like age, parity, smoking, use of alcohol, and body mass index, subfertility, and previous pregnancies including previous birth of a malformed child, socioeconomy, race/ethnicity, or country of birth. Confounding by concomitant maternal drug use may occur. A geographical or seasonal confounding can exist. In rare instances, infant sex and multiple birth can appear as confounders. The... (More)
- In most epidemilogical studies, the problem of confounding adds to the uncertainty in conclusions drawn. This is also true for studies on the effect of maternal drug use on birth defect risks. This paper describes various types of such confounders and discusses methods to identify and adjust for them. Such confounders can be found in maternal characteristics like age, parity, smoking, use of alcohol, and body mass index, subfertility, and previous pregnancies including previous birth of a malformed child, socioeconomy, race/ethnicity, or country of birth. Confounding by concomitant maternal drug use may occur. A geographical or seasonal confounding can exist. In rare instances, infant sex and multiple birth can appear as confounders. The most difficult problem to solve is often confounding by indication. The problem of confounding is less important for congenital malformations than for many other pregnancy outcomes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2273679
- author
- Källén, Bengt LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Obstetrics and Gynecology International
- volume
- 2012
- article number
- 148616
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:22190949
- pmid:22190949
- ISSN
- 1687-9589
- DOI
- 10.1155/2012/148616
- language
- English
- LU publication?
- yes
- id
- 15df67c4-cf6b-4ab1-a1f5-1f5384136eb1 (old id 2273679)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22190949?dopt=Abstract
- date added to LUP
- 2016-04-01 10:03:17
- date last changed
- 2018-11-21 19:40:24
@article{15df67c4-cf6b-4ab1-a1f5-1f5384136eb1,
abstract = {{In most epidemilogical studies, the problem of confounding adds to the uncertainty in conclusions drawn. This is also true for studies on the effect of maternal drug use on birth defect risks. This paper describes various types of such confounders and discusses methods to identify and adjust for them. Such confounders can be found in maternal characteristics like age, parity, smoking, use of alcohol, and body mass index, subfertility, and previous pregnancies including previous birth of a malformed child, socioeconomy, race/ethnicity, or country of birth. Confounding by concomitant maternal drug use may occur. A geographical or seasonal confounding can exist. In rare instances, infant sex and multiple birth can appear as confounders. The most difficult problem to solve is often confounding by indication. The problem of confounding is less important for congenital malformations than for many other pregnancy outcomes.}},
author = {{Källén, Bengt}},
issn = {{1687-9589}},
language = {{eng}},
publisher = {{Hindawi Limited}},
series = {{Obstetrics and Gynecology International}},
title = {{The problem of confounding in studies of the effect of maternal drug use on pregnancy outcome.}},
url = {{https://lup.lub.lu.se/search/files/1516160/2344030.pdf}},
doi = {{10.1155/2012/148616}},
volume = {{2012}},
year = {{2012}},
}