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Fibre intake and the development of inflammatory bowel disease : A European prospective multi-centre cohort study (EPIC-IBD)

Andersen, Vibeke; Chan, Simon; Luben, Robert; Khaw, Kay Tee; Olsen, Anja; Tjonneland, Anne; Kaaks, R.; Grip, Olof LU ; Bergmann, M. M. and Boeing, H., et al. (2018) In Journal of Crohn's and Colitis 12(2). p.129-136
Abstract

Background and Aims: Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population. Methods: In total, 401 326 participants, aged 20-80 years, were recruited in eight countries in Europe between 1991 and 1998. At baseline, fibre intake [total fibres, fibres from fruit, vegetables and cereals] was recorded using food frequency questionnaires. The cohort was monitored for the development of inflammatory bowel disease. Each case was matched with four controls and odds ratios [ORs] for the exposures were... (More)

Background and Aims: Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population. Methods: In total, 401 326 participants, aged 20-80 years, were recruited in eight countries in Europe between 1991 and 1998. At baseline, fibre intake [total fibres, fibres from fruit, vegetables and cereals] was recorded using food frequency questionnaires. The cohort was monitored for the development of inflammatory bowel disease. Each case was matched with four controls and odds ratios [ORs] for the exposures were calculated using conditional logistic regression. Sensitivity analyses according to smoking status were computed. Results: In total, 104 and 221 participants developed incident CD and UC, respectively. For both CD and UC, there were no statistically significant associations with either quartiles, or trends across quartiles, for total fibre or any of the individual sources. The associations were not affected by adjusting for smoking and energy intake. Stratification according to smoking status showed null findings apart from an inverse association with cereal fibre and CD in non-smokers [Quartile 4 vs 1 OR = 0.12, 95% confidence interval = 0.02-0.75, p = 0.023, OR trend across quartiles = 0.50, 95% confidence interval = 0.29-0.86, p = 0.017]. Conclusion: The results do not support the hypothesis that dietary fibre is involved in the aetiology of UC, although future work should investigate whether there may be a protective effect of specific types of fibre according to smoking status in CD.

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type
Contribution to journal
publication status
published
subject
keywords
Diet, Dietary fibre, Epidemiology, Fibre food, Inflammatory bowel disease, Prospective study
in
Journal of Crohn's and Colitis
volume
12
issue
2
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:85041301260
ISSN
1873-9946
DOI
10.1093/ecco-jcc/jjx136
language
English
LU publication?
no
id
15e2978e-d92a-48be-a664-ebd904a2b3b6
date added to LUP
2018-02-21 11:59:18
date last changed
2018-06-10 05:27:03
@article{15e2978e-d92a-48be-a664-ebd904a2b3b6,
  abstract     = {<p>Background and Aims: Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population. Methods: In total, 401 326 participants, aged 20-80 years, were recruited in eight countries in Europe between 1991 and 1998. At baseline, fibre intake [total fibres, fibres from fruit, vegetables and cereals] was recorded using food frequency questionnaires. The cohort was monitored for the development of inflammatory bowel disease. Each case was matched with four controls and odds ratios [ORs] for the exposures were calculated using conditional logistic regression. Sensitivity analyses according to smoking status were computed. Results: In total, 104 and 221 participants developed incident CD and UC, respectively. For both CD and UC, there were no statistically significant associations with either quartiles, or trends across quartiles, for total fibre or any of the individual sources. The associations were not affected by adjusting for smoking and energy intake. Stratification according to smoking status showed null findings apart from an inverse association with cereal fibre and CD in non-smokers [Quartile 4 vs 1 OR = 0.12, 95% confidence interval = 0.02-0.75, p = 0.023, OR trend across quartiles = 0.50, 95% confidence interval = 0.29-0.86, p = 0.017]. Conclusion: The results do not support the hypothesis that dietary fibre is involved in the aetiology of UC, although future work should investigate whether there may be a protective effect of specific types of fibre according to smoking status in CD.</p>},
  articleno    = {jjx136},
  author       = {Andersen, Vibeke and Chan, Simon and Luben, Robert and Khaw, Kay Tee and Olsen, Anja and Tjonneland, Anne and Kaaks, R. and Grip, Olof and Bergmann, M. M. and Boeing, H. and Hultdin, Johan and Karling, Pontus and Overvad, Kim and Oldenburg, Bas and Opstelten, Jorrit and Boutron-Ruault, Marie Christine and Carbonnel, Franck and Racine, Antoine and Key, Timothy and Masala, Giovanna and Palli, Domenico and Tumino, R. and Trichopoulou, A. and Riboli, Elio and Hart, Andrew},
  issn         = {1873-9946},
  keyword      = {Diet,Dietary fibre,Epidemiology,Fibre food,Inflammatory bowel disease,Prospective study},
  language     = {eng},
  number       = {2},
  pages        = {129--136},
  publisher    = {Elsevier},
  series       = {Journal of Crohn's and Colitis},
  title        = {Fibre intake and the development of inflammatory bowel disease : A European prospective multi-centre cohort study (EPIC-IBD)},
  url          = {http://dx.doi.org/10.1093/ecco-jcc/jjx136},
  volume       = {12},
  year         = {2018},
}