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Alzheimer's disease (AD) with and without white matter pathology-clinical identification of concurrent cardiovascular disorders.

Andin, Ulla LU ; Passant, Ulla LU ; Gustafson, Lars LU and Englund, Elisabet LU (2007) In Archives of Gerontology and Geriatrics 44. p.277-286
Abstract
Clinical vascular features, either as manifest vascular disease or as cardiovascular risk factors were compared in AD with and without neuropathological white matter disease (WMD). The aim of the study was to investigate whether the presence of WMD and the severity of either AD pathology or WMD were associated with different cardiovascular profiles. A total of 44 AD cases were retrospectively studied. All the cases were neuropathologically diagnosed as AD with WMD (n = 22) and as AD without WMD (n = 22), respectively. The patients' medical records were studied with regard to their medical history and to somatic and neurological findings including arrhythmia, congestive heart failure, angina, myocardial infarctions, signs of TIA/stroke,... (More)
Clinical vascular features, either as manifest vascular disease or as cardiovascular risk factors were compared in AD with and without neuropathological white matter disease (WMD). The aim of the study was to investigate whether the presence of WMD and the severity of either AD pathology or WMD were associated with different cardiovascular profiles. A total of 44 AD cases were retrospectively studied. All the cases were neuropathologically diagnosed as AD with WMD (n = 22) and as AD without WMD (n = 22), respectively. The patients' medical records were studied with regard to their medical history and to somatic and neurological findings including arrhythmia, congestive heart failure, angina, myocardial infarctions, signs of TIA/stroke, diabetes mellitus, and blood pressure abnormalities, such as hypertension and orthostatic hypotension. In AD-WMD, hypertension, orthostatic hypotension as well as dizziness/unsteadiness were significantly more common than in AD without WMD. Cardiovascular symptoms were more frequent in AD-WMD than in the other group, though the difference did not reach statistical significance. Hypothetically, abnormal and unstable blood pressure levels underlie recurrent cerebral hypoperfusion, which may in turn leave room for the development of WMD. Furthermore, dizziness/unsteadiness may be a symptom reflecting the presence of WMD. (c) 2006 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Gerontology and Geriatrics
volume
44
pages
277 - 286
publisher
Elsevier
external identifiers
  • wos:000245612900007
  • scopus:33846886946
ISSN
1872-6976
DOI
10.1016/j.archger.2006.06.002
language
English
LU publication?
yes
id
ab4cbd71-1ccd-4a1f-8d5c-2d6f72bb8fb9 (old id 160034)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16920207&dopt=Abstract
date added to LUP
2007-07-13 11:31:55
date last changed
2017-01-01 06:57:48
@article{ab4cbd71-1ccd-4a1f-8d5c-2d6f72bb8fb9,
  abstract     = {Clinical vascular features, either as manifest vascular disease or as cardiovascular risk factors were compared in AD with and without neuropathological white matter disease (WMD). The aim of the study was to investigate whether the presence of WMD and the severity of either AD pathology or WMD were associated with different cardiovascular profiles. A total of 44 AD cases were retrospectively studied. All the cases were neuropathologically diagnosed as AD with WMD (n = 22) and as AD without WMD (n = 22), respectively. The patients' medical records were studied with regard to their medical history and to somatic and neurological findings including arrhythmia, congestive heart failure, angina, myocardial infarctions, signs of TIA/stroke, diabetes mellitus, and blood pressure abnormalities, such as hypertension and orthostatic hypotension. In AD-WMD, hypertension, orthostatic hypotension as well as dizziness/unsteadiness were significantly more common than in AD without WMD. Cardiovascular symptoms were more frequent in AD-WMD than in the other group, though the difference did not reach statistical significance. Hypothetically, abnormal and unstable blood pressure levels underlie recurrent cerebral hypoperfusion, which may in turn leave room for the development of WMD. Furthermore, dizziness/unsteadiness may be a symptom reflecting the presence of WMD. (c) 2006 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Andin, Ulla and Passant, Ulla and Gustafson, Lars and Englund, Elisabet},
  issn         = {1872-6976},
  language     = {eng},
  pages        = {277--286},
  publisher    = {Elsevier},
  series       = {Archives of Gerontology and Geriatrics},
  title        = {Alzheimer's disease (AD) with and without white matter pathology-clinical identification of concurrent cardiovascular disorders.},
  url          = {http://dx.doi.org/10.1016/j.archger.2006.06.002},
  volume       = {44},
  year         = {2007},
}