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Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Vrieling, Alina; Bueno-de-Mesquita, H. Bas; Boshuizen, Hendriek C.; Michaud, Dominique S.; Severinsen, Marianne T.; Overvad, Kim; Olsen, Anja; Tjonneland, Anne; Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine, et al. (2010) In International Journal of Cancer 126(10). p.2394-2403
Abstract
Cigarette smoking is an established risk factor for pancreatic cancer. However, prospective data for most European countries are lacking, and epidemiologic studies on exposure to environmental tobacco smoke (ETS) in relation to pancreatic cancer risk are scarce. We examined the association of cigarette smoking and exposure to ETS with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis was based on 465,910 participants, including 524 first incident pancreatic cancer cases diagnosed after a median follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models and adjusted for weight, height, and history of diabetes mellitus. An increased risk of... (More)
Cigarette smoking is an established risk factor for pancreatic cancer. However, prospective data for most European countries are lacking, and epidemiologic studies on exposure to environmental tobacco smoke (ETS) in relation to pancreatic cancer risk are scarce. We examined the association of cigarette smoking and exposure to ETS with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis was based on 465,910 participants, including 524 first incident pancreatic cancer cases diagnosed after a median follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models and adjusted for weight, height, and history of diabetes mellitus. An increased risk of pancreatic cancer was found for current cigarette smokers compared with never smokers (HR = 1.71, 95% Cl = 1.36 2.15), and risk increased with greater intensity and pack-years. Former cigarette smokers who quit for less than 5 years were at increased risk of pancreatic cancer (HR = 1.78, 95% Cl = 1.23-2.56), but risk was comparable to never smokers after quitting for 5 years or more. Pancreatic cancer risk was increased among never smokers daily exposed to ETS (for many hours) during childhood (HR = 2.61, 95% Cl = 0.96-7.10) and exposed to ETS at home and/or work (HR = 1.54, 95% Cl = 1.00-2.39). These results suggest that both active cigarette smoking, as well as exposure to ETS, is associated with increased risk of pancreatic cancer and that risk is reduced to levels of never smokers within 5 years of quitting. (Less)
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published
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keywords
cohort study, environmental tobacco smoke, smoking, pancreatic cancer, cigarette
in
International Journal of Cancer
volume
126
issue
10
pages
2394 - 2403
publisher
John Wiley & Sons
external identifiers
  • wos:000276928700013
  • scopus:77951213081
ISSN
0020-7136
DOI
10.1002/ijc.24907
language
English
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yes
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b854c59b-d9bd-40de-987e-abbde7837b1c (old id 1601705)
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2010-05-20 10:12:31
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@article{b854c59b-d9bd-40de-987e-abbde7837b1c,
  abstract     = {Cigarette smoking is an established risk factor for pancreatic cancer. However, prospective data for most European countries are lacking, and epidemiologic studies on exposure to environmental tobacco smoke (ETS) in relation to pancreatic cancer risk are scarce. We examined the association of cigarette smoking and exposure to ETS with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis was based on 465,910 participants, including 524 first incident pancreatic cancer cases diagnosed after a median follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models and adjusted for weight, height, and history of diabetes mellitus. An increased risk of pancreatic cancer was found for current cigarette smokers compared with never smokers (HR = 1.71, 95% Cl = 1.36 2.15), and risk increased with greater intensity and pack-years. Former cigarette smokers who quit for less than 5 years were at increased risk of pancreatic cancer (HR = 1.78, 95% Cl = 1.23-2.56), but risk was comparable to never smokers after quitting for 5 years or more. Pancreatic cancer risk was increased among never smokers daily exposed to ETS (for many hours) during childhood (HR = 2.61, 95% Cl = 0.96-7.10) and exposed to ETS at home and/or work (HR = 1.54, 95% Cl = 1.00-2.39). These results suggest that both active cigarette smoking, as well as exposure to ETS, is associated with increased risk of pancreatic cancer and that risk is reduced to levels of never smokers within 5 years of quitting.},
  author       = {Vrieling, Alina and Bueno-de-Mesquita, H. Bas and Boshuizen, Hendriek C. and Michaud, Dominique S. and Severinsen, Marianne T. and Overvad, Kim and Olsen, Anja and Tjonneland, Anne and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Kaaks, Rudolf and Rohrmann, Sabine and Boeing, Heiner and Noethlings, Ute and Trichopoulou, Antonia and Moutsiou, Eftihia and Dilis, Vardis and Palli, Domenico and Krogh, Vittorio and Panico, Salvatore and Tumino, Rosario and Vineis, Paolo and van Gils, Carla H. and Peeters, Petra H. M. and Lund, Eiliv and Gram, Inger T. and Rodriguez, Laudina and Agudo, Antonio and Larranaga, Nerea and Sanchez, Maria-Jose and Navarro, Carmen and Barricarte, Aurelio and Manjer, Jonas and Lindkvist, Björn and Sund, Malin and Ye, Weimin and Bingham, Sheila and Khaw, Kay-Tee and Roddam, Andrew and Key, Tim and Boffetta, Paolo and Duell, Eric J. and Jenab, Mazda and Gallo, Valentina and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {cohort study,environmental tobacco smoke,smoking,pancreatic cancer,cigarette},
  language     = {eng},
  number       = {10},
  pages        = {2394--2403},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.24907},
  volume       = {126},
  year         = {2010},
}