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Tuberculosis burden in an urban population: a cross sectional tuberculosis survey from Guinea Bissau

Bjerregaard-Andersen, Morten; da Silva, Zacarias J.; Ravn, Pernille; Ruhwald, Morten; Andersen, Paul L.; Sodemann, Morten; Gustafson, Per LU ; Aaby, Peter and Wejse, Christian (2010) In BMC Infectious Diseases 10.
Abstract
Background: Little is known about the prevalence of pulmonary tuberculosis (TB) in low income countries. We conducted a cross sectional survey for pulmonary TB and TB symptoms in Bissau, Guinea-Bissau, in an urban cohort with known HIV prevalence. TB surveillance in the area is routinely based on passive case finding. Methods: Two cohorts were selected based on a previous HIV survey, but only 52.5% of those enrolled in the adult cohort had participated in the HIV survey. One cohort included all adults living in 384 randomly selected houses; in this cohort 8% (135/1687) were HIV infected. The other included individuals 50 years or older from all other houses in the study area; of these 11% (62/571) were HIV infected. Symptom screening was... (More)
Background: Little is known about the prevalence of pulmonary tuberculosis (TB) in low income countries. We conducted a cross sectional survey for pulmonary TB and TB symptoms in Bissau, Guinea-Bissau, in an urban cohort with known HIV prevalence. TB surveillance in the area is routinely based on passive case finding. Methods: Two cohorts were selected based on a previous HIV survey, but only 52.5% of those enrolled in the adult cohort had participated in the HIV survey. One cohort included all adults living in 384 randomly selected houses; in this cohort 8% (135/1687) were HIV infected. The other included individuals 50 years or older from all other houses in the study area; of these 11% (62/571) were HIV infected. Symptom screening was done through household visits using a standardised questionnaire. TB suspects were investigated with sputum smear microscopy and X-ray. Results: In the adult cohort, we found 4 cases among 2989 individuals screened, giving a total TB prevalence of 134/100,000 (95% CI 36-342/100,000). In the >50 years cohort, we found 4 cases among 571 individuals screened, giving a total prevalence of 701/100,000 (191-1784/100.000). Two of the eight detected TB cases were unknown by the TB program. Of the total TB cases five were HIV uninfected while three had unknown HIV status. The prevalence of TB symptoms was 2.1% (63/2989) and 10.3% (59/571) in the two cohorts respectively. Conclusions: In conclusion we found a moderately high prevalence of pulmonary TB and TB symptoms in the general population, higher among elderly individuals. By active case finding unknown cases were detected. Better awareness of TB and its symptoms needs to be promoted in low income settings. (Less)
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author
organization
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type
Contribution to journal
publication status
published
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in
BMC Infectious Diseases
volume
10
publisher
BioMed Central
external identifiers
  • wos:000277055300001
  • scopus:77950814041
ISSN
1471-2334
DOI
10.1186/1471-2334-10-96
language
English
LU publication?
yes
id
c8961baf-3591-470f-9969-4ea578eab056 (old id 1601871)
date added to LUP
2010-05-20 08:51:10
date last changed
2018-05-29 09:53:40
@article{c8961baf-3591-470f-9969-4ea578eab056,
  abstract     = {Background: Little is known about the prevalence of pulmonary tuberculosis (TB) in low income countries. We conducted a cross sectional survey for pulmonary TB and TB symptoms in Bissau, Guinea-Bissau, in an urban cohort with known HIV prevalence. TB surveillance in the area is routinely based on passive case finding. Methods: Two cohorts were selected based on a previous HIV survey, but only 52.5% of those enrolled in the adult cohort had participated in the HIV survey. One cohort included all adults living in 384 randomly selected houses; in this cohort 8% (135/1687) were HIV infected. The other included individuals 50 years or older from all other houses in the study area; of these 11% (62/571) were HIV infected. Symptom screening was done through household visits using a standardised questionnaire. TB suspects were investigated with sputum smear microscopy and X-ray. Results: In the adult cohort, we found 4 cases among 2989 individuals screened, giving a total TB prevalence of 134/100,000 (95% CI 36-342/100,000). In the >50 years cohort, we found 4 cases among 571 individuals screened, giving a total prevalence of 701/100,000 (191-1784/100.000). Two of the eight detected TB cases were unknown by the TB program. Of the total TB cases five were HIV uninfected while three had unknown HIV status. The prevalence of TB symptoms was 2.1% (63/2989) and 10.3% (59/571) in the two cohorts respectively. Conclusions: In conclusion we found a moderately high prevalence of pulmonary TB and TB symptoms in the general population, higher among elderly individuals. By active case finding unknown cases were detected. Better awareness of TB and its symptoms needs to be promoted in low income settings.},
  author       = {Bjerregaard-Andersen, Morten and da Silva, Zacarias J. and Ravn, Pernille and Ruhwald, Morten and Andersen, Paul L. and Sodemann, Morten and Gustafson, Per and Aaby, Peter and Wejse, Christian},
  issn         = {1471-2334},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Infectious Diseases},
  title        = {Tuberculosis burden in an urban population: a cross sectional tuberculosis survey from Guinea Bissau},
  url          = {http://dx.doi.org/10.1186/1471-2334-10-96},
  volume       = {10},
  year         = {2010},
}