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High Levels of Endothelin (ET)-1 and Aneurysm Diameter Independently Predict Growth of Stable Abdominal Aortic Aneurysms

Flondell-Sité, Despina LU ; Lindblad, Bengt LU and Gottsäter, Anders LU (2010) In Angiology 61(4). p.324-328
Abstract
The etiology of abdominal aortic aneurysm (AAA) includes inflammation and endothelial dysfunction. To evaluate relations between these mechanisms and AAA growth, endothelin (ET)-1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and CD40 ligand were related to yearly AAA growth for 2.9 +/- 1.6 years (mean +/- SD) in 178 patients with conservatively followed AAA. Total number of follow-up years was 491. Abdominal aortic aneurysm diameter increased by 3.3 +/- 4.0 mm during the first year and by 4.9 +/- 4.4 mm during the first 2 years. Median (range) growth was 2.5 (-1.0 to 30.6) mm/year. When patients with AAA growth above or below median were compared, initial AAA diameter (46.1 +/- 5.8 vs 42.0 +/- 8.3 mm; P < .0001), age (75 +/-... (More)
The etiology of abdominal aortic aneurysm (AAA) includes inflammation and endothelial dysfunction. To evaluate relations between these mechanisms and AAA growth, endothelin (ET)-1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and CD40 ligand were related to yearly AAA growth for 2.9 +/- 1.6 years (mean +/- SD) in 178 patients with conservatively followed AAA. Total number of follow-up years was 491. Abdominal aortic aneurysm diameter increased by 3.3 +/- 4.0 mm during the first year and by 4.9 +/- 4.4 mm during the first 2 years. Median (range) growth was 2.5 (-1.0 to 30.6) mm/year. When patients with AAA growth above or below median were compared, initial AAA diameter (46.1 +/- 5.8 vs 42.0 +/- 8.3 mm; P < .0001), age (75 +/- 7 vs 72 +/- 8 years; P < .029), and initial ET-1 levels (1.31 +/- 0.50 vs 1.13 +/- 0.49 pg/mL; P <.0177) were higher in patients with growth above median. Endothelin 1 (P = .0230) and initial AAA diameter (P = .0019) predicted AAA growth above median in logistic regression. In conclusion, higher initial levels of ET-1 and initial AAA diameter independently predict AAA growth. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tumor necrosis factor alpha, inflammation, statin, endothelin 1, abdominal aortic aneurysm, growth, interleukin 6, CD40 ligand
in
Angiology
volume
61
issue
4
pages
324 - 328
publisher
SAGE Publications Inc.
external identifiers
  • wos:000276897300002
  • scopus:77952710858
ISSN
0003-3197
DOI
10.1177/0003319709344190
language
English
LU publication?
yes
id
b2163164-2da7-4426-b2e3-e010be3dce24 (old id 1601922)
date added to LUP
2010-05-19 11:18:18
date last changed
2018-05-29 09:27:33
@article{b2163164-2da7-4426-b2e3-e010be3dce24,
  abstract     = {The etiology of abdominal aortic aneurysm (AAA) includes inflammation and endothelial dysfunction. To evaluate relations between these mechanisms and AAA growth, endothelin (ET)-1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and CD40 ligand were related to yearly AAA growth for 2.9 +/- 1.6 years (mean +/- SD) in 178 patients with conservatively followed AAA. Total number of follow-up years was 491. Abdominal aortic aneurysm diameter increased by 3.3 +/- 4.0 mm during the first year and by 4.9 +/- 4.4 mm during the first 2 years. Median (range) growth was 2.5 (-1.0 to 30.6) mm/year. When patients with AAA growth above or below median were compared, initial AAA diameter (46.1 +/- 5.8 vs 42.0 +/- 8.3 mm; P &lt; .0001), age (75 +/- 7 vs 72 +/- 8 years; P &lt; .029), and initial ET-1 levels (1.31 +/- 0.50 vs 1.13 +/- 0.49 pg/mL; P &lt;.0177) were higher in patients with growth above median. Endothelin 1 (P = .0230) and initial AAA diameter (P = .0019) predicted AAA growth above median in logistic regression. In conclusion, higher initial levels of ET-1 and initial AAA diameter independently predict AAA growth.},
  author       = {Flondell-Sité, Despina and Lindblad, Bengt and Gottsäter, Anders},
  issn         = {0003-3197},
  keyword      = {tumor necrosis factor alpha,inflammation,statin,endothelin 1,abdominal aortic aneurysm,growth,interleukin 6,CD40 ligand},
  language     = {eng},
  number       = {4},
  pages        = {324--328},
  publisher    = {SAGE Publications Inc.},
  series       = {Angiology},
  title        = {High Levels of Endothelin (ET)-1 and Aneurysm Diameter Independently Predict Growth of Stable Abdominal Aortic Aneurysms},
  url          = {http://dx.doi.org/10.1177/0003319709344190},
  volume       = {61},
  year         = {2010},
}