Weight-change as a prognostic marker in 12 550 patients following acute myocardial infarction or with stable coronary artery disease.
(2006) In European Heart Journal 27. p.2755-2762- Abstract
- Aims To examine the prognostic importance of weight-change in patients with coronary artery disease (CAD), especially following acute myocardial infarction (AMI). Methods and results In 4360 AMI patients (OPTIMAAL trial) without baseline oedema, we assessed 3-month weight-change, baseline body mass index (BMI), demographics, patient history, medication, physical examination, and biochemical analyses. Weight-change was defined as change >+/- 0.1 kg/baseline BMI-unit. Patients were accordingly categorized into three groups; weight-loss, weight-stability, and weight-gain. Our findings were validated in 4012 AMI patients (CONSENSUS II trial) and 4178 stable CAD patients (79% with prior AMI, 4S trial). Median follow-up was 2.7 years, 3... (More)
- Aims To examine the prognostic importance of weight-change in patients with coronary artery disease (CAD), especially following acute myocardial infarction (AMI). Methods and results In 4360 AMI patients (OPTIMAAL trial) without baseline oedema, we assessed 3-month weight-change, baseline body mass index (BMI), demographics, patient history, medication, physical examination, and biochemical analyses. Weight-change was defined as change >+/- 0.1 kg/baseline BMI-unit. Patients were accordingly categorized into three groups; weight-loss, weight-stability, and weight-gain. Our findings were validated in 4012 AMI patients (CONSENSUS II trial) and 4178 stable CAD patients (79% with prior AMI, 4S trial). Median follow-up was 2.7 years, 3 months, and 4.4 years, respectively. In OPTIMAAL, 3-month weight-loss (vs. weight-stability) independently predicted increased all-cause death [n=471; hazard ratio (HR) 1.26; 95% CI 1.01-1.56; P=0.039] and cardiac death (n=299, HR 1.33, 95% CI 1.02-1.73, P=0.034). Weight-gain yielded risk similar to weight-stability (HR 1.07, P=0.592 and 0.97, P=0.866, respectively). In CONSENSUS II, 3-month weight-loss independently predicted increased mortality (HR 3.87, P=0.008). Weight-gain yielded risk similar to weight-stability (HR 1.11, P=0.860). In 4S, 1-year weight-loss independently predicted increased mortality (HR 1.44, P=0.004). Weight-gain conferred risk similar to weight-stability (HR 1.05, P=0.735). Conclusion In patients following AMI or with stable CAD, weight-loss but not weight-gain was independently associated with increased mortality risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/160248
- author
- Kennedy, Linn LU ; Dickstein, Kenneth ; Anker, Stefan D ; James, Margaret ; Cook, Thomas J ; Kristianson, Krister and Willenheimer, Ronnie LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- mortality, prognosis, weight-change, coronary artery disease, acute myocardial infarction
- in
- European Heart Journal
- volume
- 27
- pages
- 2755 - 2762
- publisher
- Oxford University Press
- external identifiers
-
- wos:000242472100009
- scopus:33845321921
- ISSN
- 1522-9645
- DOI
- 10.1093/eurheartj/ehl182
- language
- English
- LU publication?
- yes
- id
- eff0838f-fedd-4669-8126-87d19c078006 (old id 160248)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16891382&dopt=Abstract
- date added to LUP
- 2016-04-01 17:10:57
- date last changed
- 2022-01-29 00:55:30
@article{eff0838f-fedd-4669-8126-87d19c078006,
abstract = {{Aims To examine the prognostic importance of weight-change in patients with coronary artery disease (CAD), especially following acute myocardial infarction (AMI). Methods and results In 4360 AMI patients (OPTIMAAL trial) without baseline oedema, we assessed 3-month weight-change, baseline body mass index (BMI), demographics, patient history, medication, physical examination, and biochemical analyses. Weight-change was defined as change >+/- 0.1 kg/baseline BMI-unit. Patients were accordingly categorized into three groups; weight-loss, weight-stability, and weight-gain. Our findings were validated in 4012 AMI patients (CONSENSUS II trial) and 4178 stable CAD patients (79% with prior AMI, 4S trial). Median follow-up was 2.7 years, 3 months, and 4.4 years, respectively. In OPTIMAAL, 3-month weight-loss (vs. weight-stability) independently predicted increased all-cause death [n=471; hazard ratio (HR) 1.26; 95% CI 1.01-1.56; P=0.039] and cardiac death (n=299, HR 1.33, 95% CI 1.02-1.73, P=0.034). Weight-gain yielded risk similar to weight-stability (HR 1.07, P=0.592 and 0.97, P=0.866, respectively). In CONSENSUS II, 3-month weight-loss independently predicted increased mortality (HR 3.87, P=0.008). Weight-gain yielded risk similar to weight-stability (HR 1.11, P=0.860). In 4S, 1-year weight-loss independently predicted increased mortality (HR 1.44, P=0.004). Weight-gain conferred risk similar to weight-stability (HR 1.05, P=0.735). Conclusion In patients following AMI or with stable CAD, weight-loss but not weight-gain was independently associated with increased mortality risk.}},
author = {{Kennedy, Linn and Dickstein, Kenneth and Anker, Stefan D and James, Margaret and Cook, Thomas J and Kristianson, Krister and Willenheimer, Ronnie}},
issn = {{1522-9645}},
keywords = {{mortality; prognosis; weight-change; coronary artery disease; acute myocardial infarction}},
language = {{eng}},
pages = {{2755--2762}},
publisher = {{Oxford University Press}},
series = {{European Heart Journal}},
title = {{Weight-change as a prognostic marker in 12 550 patients following acute myocardial infarction or with stable coronary artery disease.}},
url = {{http://dx.doi.org/10.1093/eurheartj/ehl182}},
doi = {{10.1093/eurheartj/ehl182}},
volume = {{27}},
year = {{2006}},
}