Biomarkers of oxidative stress in overweight men are not influenced by a combination of antioxidants
(2010) In Free Radical Research 44(5). p.522-528- Abstract
- The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or double dose of antioxidants was provided to the subjects. Metabolic variables, plasma antioxidants and biomarkers of oxidative stress (lipid peroxidation and DNA damage) were measured. No effect of supplementation on biomarkers of oxidative stress was observed. Both intervention groups showed substantial increases of plasma antioxidants. This study demonstrated that supplementation with a combination of antioxidants did not affect... (More)
- The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or double dose of antioxidants was provided to the subjects. Metabolic variables, plasma antioxidants and biomarkers of oxidative stress (lipid peroxidation and DNA damage) were measured. No effect of supplementation on biomarkers of oxidative stress was observed. Both intervention groups showed substantial increases of plasma antioxidants. This study demonstrated that supplementation with a combination of antioxidants did not affect lipid peroxidation and DNA damage in overweight men, despite increased concentrations of plasma antioxidants. The absence of antioxidant supplement effect might possibly be explained by the chosen study group having a normal level of oxidative stress, duration of the intervention and/or doses of antioxidants. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1603083
- author
- Rytter, Elisabet ; Johansson, Clara ; Vessby, Bengt ; Sjodin, Anders ; Moller, Lennart ; Åkesson, Björn LU and Basu, Samar
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Free Radical Research
- volume
- 44
- issue
- 5
- pages
- 522 - 528
- publisher
- Harwood Academic
- external identifiers
-
- wos:000276815300005
- scopus:77951293833
- pmid:20298120
- ISSN
- 1029-2470
- DOI
- 10.3109/10715761003647101
- language
- English
- LU publication?
- yes
- id
- 12666149-ba35-458b-ac6e-83bbbc24cfd9 (old id 1603083)
- date added to LUP
- 2016-04-01 13:58:30
- date last changed
- 2025-04-04 14:55:12
@article{12666149-ba35-458b-ac6e-83bbbc24cfd9,
abstract = {{The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or double dose of antioxidants was provided to the subjects. Metabolic variables, plasma antioxidants and biomarkers of oxidative stress (lipid peroxidation and DNA damage) were measured. No effect of supplementation on biomarkers of oxidative stress was observed. Both intervention groups showed substantial increases of plasma antioxidants. This study demonstrated that supplementation with a combination of antioxidants did not affect lipid peroxidation and DNA damage in overweight men, despite increased concentrations of plasma antioxidants. The absence of antioxidant supplement effect might possibly be explained by the chosen study group having a normal level of oxidative stress, duration of the intervention and/or doses of antioxidants.}},
author = {{Rytter, Elisabet and Johansson, Clara and Vessby, Bengt and Sjodin, Anders and Moller, Lennart and Åkesson, Björn and Basu, Samar}},
issn = {{1029-2470}},
language = {{eng}},
number = {{5}},
pages = {{522--528}},
publisher = {{Harwood Academic}},
series = {{Free Radical Research}},
title = {{Biomarkers of oxidative stress in overweight men are not influenced by a combination of antioxidants}},
url = {{http://dx.doi.org/10.3109/10715761003647101}},
doi = {{10.3109/10715761003647101}},
volume = {{44}},
year = {{2010}},
}