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Biomarkers of oxidative stress in overweight men are not influenced by a combination of antioxidants

Rytter, Elisabet; Johansson, Clara; Vessby, Bengt; Sjodin, Anders; Moller, Lennart; Åkesson, Björn LU and Basu, Samar (2010) In Free Radical Research 44(5). p.522-528
Abstract
The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or double dose of antioxidants was provided to the subjects. Metabolic variables, plasma antioxidants and biomarkers of oxidative stress (lipid peroxidation and DNA damage) were measured. No effect of supplementation on biomarkers of oxidative stress was observed. Both intervention groups showed substantial increases of plasma antioxidants. This study demonstrated that supplementation with a combination of antioxidants did not affect... (More)
The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or double dose of antioxidants was provided to the subjects. Metabolic variables, plasma antioxidants and biomarkers of oxidative stress (lipid peroxidation and DNA damage) were measured. No effect of supplementation on biomarkers of oxidative stress was observed. Both intervention groups showed substantial increases of plasma antioxidants. This study demonstrated that supplementation with a combination of antioxidants did not affect lipid peroxidation and DNA damage in overweight men, despite increased concentrations of plasma antioxidants. The absence of antioxidant supplement effect might possibly be explained by the chosen study group having a normal level of oxidative stress, duration of the intervention and/or doses of antioxidants. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Free Radical Research
volume
44
issue
5
pages
522 - 528
publisher
Harwood Academic
external identifiers
  • wos:000276815300005
  • scopus:77951293833
ISSN
1029-2470
DOI
10.3109/10715761003647101
language
English
LU publication?
yes
id
12666149-ba35-458b-ac6e-83bbbc24cfd9 (old id 1603083)
date added to LUP
2010-05-19 09:56:57
date last changed
2018-05-29 11:07:52
@article{12666149-ba35-458b-ac6e-83bbbc24cfd9,
  abstract     = {The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or double dose of antioxidants was provided to the subjects. Metabolic variables, plasma antioxidants and biomarkers of oxidative stress (lipid peroxidation and DNA damage) were measured. No effect of supplementation on biomarkers of oxidative stress was observed. Both intervention groups showed substantial increases of plasma antioxidants. This study demonstrated that supplementation with a combination of antioxidants did not affect lipid peroxidation and DNA damage in overweight men, despite increased concentrations of plasma antioxidants. The absence of antioxidant supplement effect might possibly be explained by the chosen study group having a normal level of oxidative stress, duration of the intervention and/or doses of antioxidants.},
  author       = {Rytter, Elisabet and Johansson, Clara and Vessby, Bengt and Sjodin, Anders and Moller, Lennart and Åkesson, Björn and Basu, Samar},
  issn         = {1029-2470},
  language     = {eng},
  number       = {5},
  pages        = {522--528},
  publisher    = {Harwood Academic},
  series       = {Free Radical Research},
  title        = {Biomarkers of oxidative stress in overweight men are not influenced by a combination of antioxidants},
  url          = {http://dx.doi.org/10.3109/10715761003647101},
  volume       = {44},
  year         = {2010},
}