Population-attributable risk of coronary heart disease risk factors during long-term follow-up: the Malmö Preventive Project.
(2006) In Journal of Internal Medicine 260(2). p.134-141- Abstract
- Aims To calculate the population-attributable risk (PAR) of coronary events (CE) from 10 risk factors, during long-term follow-up. Methods We used both case-cohort and case-control analyses for calculation of PAR in relation to 10 baseline risk factors. First CE (fatal or nonfatal, n = 3072) in 22 444 males and 10 902 females was recorded during a mean follow-up of 20 years by use of national registers. Results Using a Cox regression analysis in a case-cohort design, smoking (prevalence in men 49%, women 37%) was the strongest risk factor, RR 2.29 (95% CI 2.09-2.52; PAR 39%), followed by hypercholesterolaemia, RR 1.70 (95% CI 1.56-1.86; PAR 18%), and diabetes, RR 1.67 (95% CI 1.41-1.99; PAR 3%). For women the strongest risk factors were... (More)
- Aims To calculate the population-attributable risk (PAR) of coronary events (CE) from 10 risk factors, during long-term follow-up. Methods We used both case-cohort and case-control analyses for calculation of PAR in relation to 10 baseline risk factors. First CE (fatal or nonfatal, n = 3072) in 22 444 males and 10 902 females was recorded during a mean follow-up of 20 years by use of national registers. Results Using a Cox regression analysis in a case-cohort design, smoking (prevalence in men 49%, women 37%) was the strongest risk factor, RR 2.29 (95% CI 2.09-2.52; PAR 39%), followed by hypercholesterolaemia, RR 1.70 (95% CI 1.56-1.86; PAR 18%), and diabetes, RR 1.67 (95% CI 1.41-1.99; PAR 3%). For women the strongest risk factors were smoking, RR 3.16 (95% CI 2.50-3.98; PAR 44%), diabetes, RR 2.59 (95% CI 1.78-3.76; PAR 6%), and hypertension, RR 2.47 (95% CI 1.94-3.14; PAR 23%). In men, smoking was the strongest predictor both after 10 years [RR 2.69 (95% CI 2.23-3.24)] and 20 years [RR 2.45 (95% CI 2.15-2.79)], followed by hypercholesterolaemia (RR 2.16-1.63), hypertension (RR 2.04-1.51), and diabetes (RR 1.85 -1.47). The case-control design gave very similar results. Total PAR varied from 74% (fully adjusted Cox regression, case-control, in men) to 116% in women (case-cohort). Conclusion Smoking is the most important long-term risk factor for CE in both genders, based on data from a population with a high proportion of smokers. Ten measured variables explained almost all variation in risk and could be used as a basis for intervention programmes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/160310
- author
- Nilsson, P M ; Nilsson, Jan-Åke LU and Berglund, Göran LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Sweden: epidemiology, Smoking: adverse effects, Non-U.S. Gov't, Health Surveys, Female, Epidemiologic Methods, Coronary Disease: prevention & control, Coronary Disease: epidemiology, Time Factors, Adult, Humans, Male, Middle Aged, Registries, Research Support
- in
- Journal of Internal Medicine
- volume
- 260
- issue
- 2
- pages
- 134 - 141
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000239006800004
- pmid:16882277
- scopus:33745953940
- ISSN
- 1365-2796
- DOI
- 10.1111/j.1365-2796.2006.01671.x
- language
- English
- LU publication?
- yes
- id
- b6044dfe-e8ee-4a24-b628-2324c3809362 (old id 160310)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16882277&dopt=Abstract
- date added to LUP
- 2016-04-01 16:29:33
- date last changed
- 2024-05-24 07:04:09
@article{b6044dfe-e8ee-4a24-b628-2324c3809362,
abstract = {{Aims To calculate the population-attributable risk (PAR) of coronary events (CE) from 10 risk factors, during long-term follow-up. Methods We used both case-cohort and case-control analyses for calculation of PAR in relation to 10 baseline risk factors. First CE (fatal or nonfatal, n = 3072) in 22 444 males and 10 902 females was recorded during a mean follow-up of 20 years by use of national registers. Results Using a Cox regression analysis in a case-cohort design, smoking (prevalence in men 49%, women 37%) was the strongest risk factor, RR 2.29 (95% CI 2.09-2.52; PAR 39%), followed by hypercholesterolaemia, RR 1.70 (95% CI 1.56-1.86; PAR 18%), and diabetes, RR 1.67 (95% CI 1.41-1.99; PAR 3%). For women the strongest risk factors were smoking, RR 3.16 (95% CI 2.50-3.98; PAR 44%), diabetes, RR 2.59 (95% CI 1.78-3.76; PAR 6%), and hypertension, RR 2.47 (95% CI 1.94-3.14; PAR 23%). In men, smoking was the strongest predictor both after 10 years [RR 2.69 (95% CI 2.23-3.24)] and 20 years [RR 2.45 (95% CI 2.15-2.79)], followed by hypercholesterolaemia (RR 2.16-1.63), hypertension (RR 2.04-1.51), and diabetes (RR 1.85 -1.47). The case-control design gave very similar results. Total PAR varied from 74% (fully adjusted Cox regression, case-control, in men) to 116% in women (case-cohort). Conclusion Smoking is the most important long-term risk factor for CE in both genders, based on data from a population with a high proportion of smokers. Ten measured variables explained almost all variation in risk and could be used as a basis for intervention programmes.}},
author = {{Nilsson, P M and Nilsson, Jan-Åke and Berglund, Göran}},
issn = {{1365-2796}},
keywords = {{Sweden: epidemiology; Smoking: adverse effects; Non-U.S. Gov't; Health Surveys; Female; Epidemiologic Methods; Coronary Disease: prevention & control; Coronary Disease: epidemiology; Time Factors; Adult; Humans; Male; Middle Aged; Registries; Research Support}},
language = {{eng}},
number = {{2}},
pages = {{134--141}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{Population-attributable risk of coronary heart disease risk factors during long-term follow-up: the Malmö Preventive Project.}},
url = {{http://dx.doi.org/10.1111/j.1365-2796.2006.01671.x}},
doi = {{10.1111/j.1365-2796.2006.01671.x}},
volume = {{260}},
year = {{2006}},
}