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Sex-specific cardiovascular morbidity and mortality in a cohort treated for hypertension.

Li, Cairu LU ; Engström, Gunnar LU ; Hedblad, Bo LU and Janzon, Lars LU (2006) In Journal of Hypertension 24(8). p.1523-1529
Abstract
Objective Incidence of cardiovascular disease (CVD) is higher in men than in women. The aim of this study was to investigate whether the gender differential can be modified by pharmacological intervention in a population-based setting. Design and method In a prospective population-based cohort - the Malmo Diet and Cancer study - a total of 3608 hypertensives (1559 men, 2049 women), 45-73 years old, with a mean of 10 years' treatment at baseline examination, participated in the study. Information on blood pressure-lowering medication was collected in a questionnaire. Incidences of first-ever cardiac event, stroke or CVD death were followed. The mean period of follow-up was 7.4 years. Results During follow-up, 341 first-ever CVD events and... (More)
Objective Incidence of cardiovascular disease (CVD) is higher in men than in women. The aim of this study was to investigate whether the gender differential can be modified by pharmacological intervention in a population-based setting. Design and method In a prospective population-based cohort - the Malmo Diet and Cancer study - a total of 3608 hypertensives (1559 men, 2049 women), 45-73 years old, with a mean of 10 years' treatment at baseline examination, participated in the study. Information on blood pressure-lowering medication was collected in a questionnaire. Incidences of first-ever cardiac event, stroke or CVD death were followed. The mean period of follow-up was 7.4 years. Results During follow-up, 341 first-ever CVD events and 128 CVD deaths occurred. The risk of CVD morbidity or mortality was significantly higher in hypertensive men than in hypertensive women: cardiac event [relative risk (RR) = 3.11; 95% confidence interval (CI): 2.13 - 4.54], stroke (RR U 1.50; 95% CI: 1.01 - 2.22) and CVD death (RR = 2.96; 95% CI: 1.86 - 4.20). However, the gender gap in CVD risks was reduced with advancing age. Two background factors - single household and concomitant diabetes - are apt to have an independent sex-specific impact on CVD risk. Conclusions Gender remains a strong independent predictor for CVD morbidity and mortality, irrespective of antihypertensive intervention or other risk factors. Increased clinical attention should be given to hypertensive men living alone and hypertensive women with diabetes. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiovascular risk, blood pressure-lowering treatment, gender, differential, hypertension
in
Journal of Hypertension
volume
24
issue
8
pages
1523 - 1529
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000240211900011
  • scopus:33746707536
ISSN
1473-5598
DOI
10.1097/01.hjh.0000239287.10013.e0
language
English
LU publication?
yes
id
14408559-09c1-4d44-beda-73a9ed9333c4 (old id 160362)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16877954&dopt=Abstract
date added to LUP
2016-04-01 15:58:37
date last changed
2021-06-23 03:56:36
@article{14408559-09c1-4d44-beda-73a9ed9333c4,
  abstract     = {Objective Incidence of cardiovascular disease (CVD) is higher in men than in women. The aim of this study was to investigate whether the gender differential can be modified by pharmacological intervention in a population-based setting. Design and method In a prospective population-based cohort - the Malmo Diet and Cancer study - a total of 3608 hypertensives (1559 men, 2049 women), 45-73 years old, with a mean of 10 years' treatment at baseline examination, participated in the study. Information on blood pressure-lowering medication was collected in a questionnaire. Incidences of first-ever cardiac event, stroke or CVD death were followed. The mean period of follow-up was 7.4 years. Results During follow-up, 341 first-ever CVD events and 128 CVD deaths occurred. The risk of CVD morbidity or mortality was significantly higher in hypertensive men than in hypertensive women: cardiac event [relative risk (RR) = 3.11; 95% confidence interval (CI): 2.13 - 4.54], stroke (RR U 1.50; 95% CI: 1.01 - 2.22) and CVD death (RR = 2.96; 95% CI: 1.86 - 4.20). However, the gender gap in CVD risks was reduced with advancing age. Two background factors - single household and concomitant diabetes - are apt to have an independent sex-specific impact on CVD risk. Conclusions Gender remains a strong independent predictor for CVD morbidity and mortality, irrespective of antihypertensive intervention or other risk factors. Increased clinical attention should be given to hypertensive men living alone and hypertensive women with diabetes.},
  author       = {Li, Cairu and Engström, Gunnar and Hedblad, Bo and Janzon, Lars},
  issn         = {1473-5598},
  language     = {eng},
  number       = {8},
  pages        = {1523--1529},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Sex-specific cardiovascular morbidity and mortality in a cohort treated for hypertension.},
  url          = {http://dx.doi.org/10.1097/01.hjh.0000239287.10013.e0},
  doi          = {10.1097/01.hjh.0000239287.10013.e0},
  volume       = {24},
  year         = {2006},
}