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Streptococcal M proteins and their role as virulence determinants.

Oehmcke, Sonja LU ; Shannon, Oonagh LU ; Mörgelin, Matthias LU and Herwald, Heiko LU (2010) In Clinica Chimica Acta 411. p.1172-1180
Abstract
Group A streptococci (GAS, Streptococcus pyogenes) are exclusive human pathogens that have been extensively studied for many decades. The spectrum of diseases caused by these bacteria ranges from uncomplicated and superficial to severe and invasive infections. In order to give rise to these complications, GAS have evolved a number of surface-bound and secreted virulence factors, of which the M proteins are probably the best characterized. Evidence has emerged that M proteins are multifunctional pathogenic determinants, and over the years many interactions between M proteins and the human host have been reported. The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M... (More)
Group A streptococci (GAS, Streptococcus pyogenes) are exclusive human pathogens that have been extensively studied for many decades. The spectrum of diseases caused by these bacteria ranges from uncomplicated and superficial to severe and invasive infections. In order to give rise to these complications, GAS have evolved a number of surface-bound and secreted virulence factors, of which the M proteins are probably the best characterized. Evidence has emerged that M proteins are multifunctional pathogenic determinants, and over the years many interactions between M proteins and the human host have been reported. The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M proteins to trigger disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinica Chimica Acta
volume
411
pages
1172 - 1180
publisher
Elsevier
external identifiers
  • wos:000280033400002
  • pmid:20452338
  • scopus:77954144724
ISSN
0009-8981
DOI
10.1016/j.cca.2010.04.032
language
English
LU publication?
yes
id
07a75db1-f8de-432b-bb62-7a871a520e56 (old id 1610473)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20452338?dopt=Abstract
date added to LUP
2010-06-01 09:57:56
date last changed
2018-05-29 10:27:07
@article{07a75db1-f8de-432b-bb62-7a871a520e56,
  abstract     = {Group A streptococci (GAS, Streptococcus pyogenes) are exclusive human pathogens that have been extensively studied for many decades. The spectrum of diseases caused by these bacteria ranges from uncomplicated and superficial to severe and invasive infections. In order to give rise to these complications, GAS have evolved a number of surface-bound and secreted virulence factors, of which the M proteins are probably the best characterized. Evidence has emerged that M proteins are multifunctional pathogenic determinants, and over the years many interactions between M proteins and the human host have been reported. The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M proteins to trigger disease.},
  author       = {Oehmcke, Sonja and Shannon, Oonagh and Mörgelin, Matthias and Herwald, Heiko},
  issn         = {0009-8981},
  language     = {eng},
  pages        = {1172--1180},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {Streptococcal M proteins and their role as virulence determinants.},
  url          = {http://dx.doi.org/10.1016/j.cca.2010.04.032},
  volume       = {411},
  year         = {2010},
}