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Cerebral palsy in children born after in vitro fertilization. Is the risk decreasing?

Källén, Bengt LU ; Finnström, O Orvar; Lindam, Anna P; Nilsson, Emma E; Nygren, Karl-Gösta and Otterblad Olausson, Petra M (2010) In European Journal of Paediatric Neurology 14. p.526-530
Abstract
BACKGROUND: Infants born after in vitro fertilization (IVF) differ from spontaneously conceived infants in a number of aspects which could increase the risk for future cerebral palsy (CP), e.g., multiple births, preterm births, neonatal complications. AIMS: To follow up children conceived by IVF with respect to risk for CP. METHODS: Infants born after IVF were identified from all IVF clinics in Sweden 1982-2007. Perinatal characteristics were obtained by linkage with the Medical Birth Register. The presence of CP in children born after IVF and in other children was identified from the Patient Register which contains diagnoses given at hospitalizations or specialist outpatient clinics. The risk for CP after IVF was studied after adjustment... (More)
BACKGROUND: Infants born after in vitro fertilization (IVF) differ from spontaneously conceived infants in a number of aspects which could increase the risk for future cerebral palsy (CP), e.g., multiple births, preterm births, neonatal complications. AIMS: To follow up children conceived by IVF with respect to risk for CP. METHODS: Infants born after IVF were identified from all IVF clinics in Sweden 1982-2007. Perinatal characteristics were obtained by linkage with the Medical Birth Register. The presence of CP in children born after IVF and in other children was identified from the Patient Register which contains diagnoses given at hospitalizations or specialist outpatient clinics. The risk for CP after IVF was studied after adjustment for year of birth, maternal age, parity, and smoking, all factors which co-vary both with IVF and with CP. Stratification was made for singletons and multiple births and for various neonatal outcomes. RESULTS: The adjusted odds ratio for CP after IVF was 1.81 (95% confidence interval, 95% CI 1.52-2.13), lower and not statistically significant when singletons or when unlike-sexed twins were analyzed. Stratification for various neonatal characteristics also reduced odds ratios to non-significant levels. For the last few years of the study (2004-2007) when the twinning rate after IVF was <10%, the odds ratio for CP was 0.97 (95% CI 0.57-1.66). CONCLUSIONS: The moderately increased risk for CP was most likely a consequence of an increased risk of neonatal morbidity, notably associated with multiple births. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Paediatric Neurology
volume
14
pages
526 - 530
publisher
Elsevier
external identifiers
  • wos:000284570200010
  • pmid:20451428
  • scopus:77958598451
ISSN
1090-3798
DOI
10.1016/j.ejpn.2010.03.007
language
English
LU publication?
yes
id
8ca3a358-521a-48e4-a6c8-6189da21dd76 (old id 1610489)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20451428?dopt=Abstract
date added to LUP
2010-06-01 10:02:09
date last changed
2018-05-29 10:02:16
@article{8ca3a358-521a-48e4-a6c8-6189da21dd76,
  abstract     = {BACKGROUND: Infants born after in vitro fertilization (IVF) differ from spontaneously conceived infants in a number of aspects which could increase the risk for future cerebral palsy (CP), e.g., multiple births, preterm births, neonatal complications. AIMS: To follow up children conceived by IVF with respect to risk for CP. METHODS: Infants born after IVF were identified from all IVF clinics in Sweden 1982-2007. Perinatal characteristics were obtained by linkage with the Medical Birth Register. The presence of CP in children born after IVF and in other children was identified from the Patient Register which contains diagnoses given at hospitalizations or specialist outpatient clinics. The risk for CP after IVF was studied after adjustment for year of birth, maternal age, parity, and smoking, all factors which co-vary both with IVF and with CP. Stratification was made for singletons and multiple births and for various neonatal outcomes. RESULTS: The adjusted odds ratio for CP after IVF was 1.81 (95% confidence interval, 95% CI 1.52-2.13), lower and not statistically significant when singletons or when unlike-sexed twins were analyzed. Stratification for various neonatal characteristics also reduced odds ratios to non-significant levels. For the last few years of the study (2004-2007) when the twinning rate after IVF was &lt;10%, the odds ratio for CP was 0.97 (95% CI 0.57-1.66). CONCLUSIONS: The moderately increased risk for CP was most likely a consequence of an increased risk of neonatal morbidity, notably associated with multiple births.},
  author       = {Källén, Bengt and Finnström, O Orvar and Lindam, Anna P and Nilsson, Emma E and Nygren, Karl-Gösta and Otterblad Olausson, Petra M},
  issn         = {1090-3798},
  language     = {eng},
  pages        = {526--530},
  publisher    = {Elsevier},
  series       = {European Journal of Paediatric Neurology},
  title        = {Cerebral palsy in children born after in vitro fertilization. Is the risk decreasing?},
  url          = {http://dx.doi.org/10.1016/j.ejpn.2010.03.007},
  volume       = {14},
  year         = {2010},
}