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Acute lung injury and ARDS in acute pancreatitis: Mechanisms and potential intervention

Zhou, Meng-Tao; Chen, Cheng-Shui; Chen, Bi-Cheng; Zhang, Qi-Yu and Andersson, Roland LU (2010) In World Journal of Gastroenterology 16(17). p.2094-2099
Abstract
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis still represents a substantial problem, with a mortality rate in the range of 30%-40%. The present review evaluates underlying pathophysiological mechanisms in both ALI and ARDS and potential clinical implications. Several mediators and pathophysiological pathways are involved during the different phases of ALI and ARDS. The initial exudative phase is characterized by diffuse alveolar damage, microvascular injury and influx of inflammatory cells. This phase is followed by a fibro-proliferative phase with lung repair, type II pneumocyte hypoplasia and proliferation of fibroblasts. Proteases derived from polymorphonuclear neutrophils, various... (More)
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis still represents a substantial problem, with a mortality rate in the range of 30%-40%. The present review evaluates underlying pathophysiological mechanisms in both ALI and ARDS and potential clinical implications. Several mediators and pathophysiological pathways are involved during the different phases of ALI and ARDS. The initial exudative phase is characterized by diffuse alveolar damage, microvascular injury and influx of inflammatory cells. This phase is followed by a fibro-proliferative phase with lung repair, type II pneumocyte hypoplasia and proliferation of fibroblasts. Proteases derived from polymorphonuclear neutrophils, various pro-inflammatory mediators, and phospholipases are all involved, among others. Contributing factors that promote pancreatitis-associated ALI may be found in the gut and mesenteric lymphatics. There is a lack of complete understanding of the underlying mechanisms, and by improving our knowledge, novel tools for prevention and intervention may be developed, thus contributing to improved outcome. (C) 2010 Baishideng. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pathophysiology, pancreatitis, Etiology, Acute, Acute lung injury, Acute respiratory distress syndrome
in
World Journal of Gastroenterology
volume
16
issue
17
pages
2094 - 2099
publisher
WJG Press
external identifiers
  • wos:000277444600004
  • scopus:77952532522
ISSN
1007-9327
DOI
10.3748/wjg.v16.i17.2094
language
English
LU publication?
yes
id
a2bd0300-79ef-4187-b80a-4545c09c59ae (old id 1618107)
alternative location
http://www.ncbi.nlm.nih.gov/sites/pubmed
date added to LUP
2010-06-21 09:31:49
date last changed
2018-07-08 03:14:34
@article{a2bd0300-79ef-4187-b80a-4545c09c59ae,
  abstract     = {Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis still represents a substantial problem, with a mortality rate in the range of 30%-40%. The present review evaluates underlying pathophysiological mechanisms in both ALI and ARDS and potential clinical implications. Several mediators and pathophysiological pathways are involved during the different phases of ALI and ARDS. The initial exudative phase is characterized by diffuse alveolar damage, microvascular injury and influx of inflammatory cells. This phase is followed by a fibro-proliferative phase with lung repair, type II pneumocyte hypoplasia and proliferation of fibroblasts. Proteases derived from polymorphonuclear neutrophils, various pro-inflammatory mediators, and phospholipases are all involved, among others. Contributing factors that promote pancreatitis-associated ALI may be found in the gut and mesenteric lymphatics. There is a lack of complete understanding of the underlying mechanisms, and by improving our knowledge, novel tools for prevention and intervention may be developed, thus contributing to improved outcome. (C) 2010 Baishideng. All rights reserved.},
  author       = {Zhou, Meng-Tao and Chen, Cheng-Shui and Chen, Bi-Cheng and Zhang, Qi-Yu and Andersson, Roland},
  issn         = {1007-9327},
  keyword      = {Pathophysiology,pancreatitis,Etiology,Acute,Acute lung injury,Acute respiratory distress syndrome},
  language     = {eng},
  number       = {17},
  pages        = {2094--2099},
  publisher    = {WJG Press},
  series       = {World Journal of Gastroenterology},
  title        = {Acute lung injury and ARDS in acute pancreatitis: Mechanisms and potential intervention},
  url          = {http://dx.doi.org/10.3748/wjg.v16.i17.2094},
  volume       = {16},
  year         = {2010},
}