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Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

Lorenz, Matthias W.; Bickel, Horst; Bots, Michiel L.; Breteler, Monique M. B.; Catapano, Alberico L.; Desvarieux, Moise; Hedblad, Bo LU ; Iglseder, Bernhard; Johnsen, Stein Harald and Juraska, Michal, et al. (2010) In American Heart Journal 159(5). p.25-730
Abstract
Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end... (More)
Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.) (Less)
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@article{d1bfe7da-cf06-4ba4-9d85-0ac6a41d8a51,
  abstract     = {Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.)},
  author       = {Lorenz, Matthias W. and Bickel, Horst and Bots, Michiel L. and Breteler, Monique M. B. and Catapano, Alberico L. and Desvarieux, Moise and Hedblad, Bo and Iglseder, Bernhard and Johnsen, Stein Harald and Juraska, Michal and Kiechl, Stefan and Mathiesen, Ellisiv B. and Norata, Giuseppe D. and Grigore, Liliana and Polak, Joseph and Poppert, Holger and Rosvall, Maria and Rundek, Tatjana and Sacco, Ralph L. and Sander, Dirk and Sitzer, Matthias and Steinmetz, Helmuth and Stensland, Eva and Willeit, Johann and Witteman, Jacqueline and Yanez, David and Thompson, Simon G.},
  issn         = {1097-6744},
  language     = {eng},
  number       = {5},
  pages        = {25--730},
  publisher    = {Mosby},
  series       = {American Heart Journal},
  title        = {Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project},
  url          = {http://dx.doi.org/10.1016/j.ahj.2010.02.008},
  volume       = {159},
  year         = {2010},
}