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Colorectal cancer in middle-aged women in relation to hormonal status: A report from the Women's Health in the Lund Area (WHILA) study.

Nazeri, Kavoos LU ; Khatibi Esfanjani, Ali LU ; Nyberg, Per LU ; Agardh, Carl-David LU ; Lidfeldt, Jonas LU and Samsioe, Göran LU (2006) In Gynecological Endocrinology 22(8). p.416-422
Abstract
Objective. To delineate a perceived association of estradiol versus estradiol plus norethisterone hormone therapy on the prevalence of colorectal cancer in postmenopausal women.



Methods. The Women's Health in the Lund Area (WHILA) project covers 10 766 women aged 50-60 years, living in the Lund area, Sweden. Out of this population, 6908 (64%) women completed questionnaires, underwent physical and laboratory assessments and had self-reported information regarding colorectal cancer. Four hundred and twenty-two (6%) were premenopausal (PM), 3600 (52%) were postmenopausal without hormone therapy (PM0), 2452 (36%) were postmenopausal with combined hormone therapy (PMT-HT) and 364 (5%) were postmenopausal with estrogen... (More)
Objective. To delineate a perceived association of estradiol versus estradiol plus norethisterone hormone therapy on the prevalence of colorectal cancer in postmenopausal women.



Methods. The Women's Health in the Lund Area (WHILA) project covers 10 766 women aged 50-60 years, living in the Lund area, Sweden. Out of this population, 6908 (64%) women completed questionnaires, underwent physical and laboratory assessments and had self-reported information regarding colorectal cancer. Four hundred and twenty-two (6%) were premenopausal (PM), 3600 (52%) were postmenopausal without hormone therapy (PM0), 2452 (36%) were postmenopausal with combined hormone therapy (PMT-HT) and 364 (5%) were postmenopausal with estrogen monotherapy (PMT-E).



Results. There were 21 cases of colorectal cancer (0.3%), one in the PM group, 16 in the PM0 group, two in the PMT-HT group and another two in the PMT-E group. Colorectal cancer prevalence was lower in the PMT-HT than in the PM0 group (odds ratio (OR) = 0.18, 95% confidence interval (CI) = 0.04-0.80). However, for the PMT-E group, the OR (95% CI) was 1.02 (0.86-1.20). There was a positive association between low physical activity (p = 0.04), low parity (p = 0.02) and risk of colorectal cancer.



Conclusion. Combined hormone therapy seemed to be associated with a lower risk of colorectal cancer in postmenopausal women in contrast to estrogen monotherapy. Hence the progestin might have a protective role. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colorectal cancer, middle-aged women, hormone therapy, estrogen monotherapy, progesterone
in
Gynecological Endocrinology
volume
22
issue
8
pages
416 - 422
publisher
Informa Healthcare
external identifiers
  • wos:000241899300002
  • scopus:33749458428
ISSN
0951-3590
DOI
10.1080/09513590600900378
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Nursing (Closed 2012) (013065000), Family Medicine (013241010), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Department of Clinical Sciences, Lund (013230000), Emergency medicine/Medicine/Surgery (013240200), Unit on Vascular Diabetic Complications (013241510), Department of Obstetrics and Gynaecology (Lund) (013018000)
id
a393b73c-ce62-40e4-9e91-1d450a3506dc (old id 162476)
date added to LUP
2016-04-01 12:12:17
date last changed
2021-02-17 01:50:38
@article{a393b73c-ce62-40e4-9e91-1d450a3506dc,
  abstract     = {Objective. To delineate a perceived association of estradiol versus estradiol plus norethisterone hormone therapy on the prevalence of colorectal cancer in postmenopausal women.<br/><br>
<br/><br>
Methods. The Women's Health in the Lund Area (WHILA) project covers 10 766 women aged 50-60 years, living in the Lund area, Sweden. Out of this population, 6908 (64%) women completed questionnaires, underwent physical and laboratory assessments and had self-reported information regarding colorectal cancer. Four hundred and twenty-two (6%) were premenopausal (PM), 3600 (52%) were postmenopausal without hormone therapy (PM0), 2452 (36%) were postmenopausal with combined hormone therapy (PMT-HT) and 364 (5%) were postmenopausal with estrogen monotherapy (PMT-E).<br/><br>
<br/><br>
Results. There were 21 cases of colorectal cancer (0.3%), one in the PM group, 16 in the PM0 group, two in the PMT-HT group and another two in the PMT-E group. Colorectal cancer prevalence was lower in the PMT-HT than in the PM0 group (odds ratio (OR) = 0.18, 95% confidence interval (CI) = 0.04-0.80). However, for the PMT-E group, the OR (95% CI) was 1.02 (0.86-1.20). There was a positive association between low physical activity (p = 0.04), low parity (p = 0.02) and risk of colorectal cancer.<br/><br>
<br/><br>
Conclusion. Combined hormone therapy seemed to be associated with a lower risk of colorectal cancer in postmenopausal women in contrast to estrogen monotherapy. Hence the progestin might have a protective role.},
  author       = {Nazeri, Kavoos and Khatibi Esfanjani, Ali and Nyberg, Per and Agardh, Carl-David and Lidfeldt, Jonas and Samsioe, Göran},
  issn         = {0951-3590},
  language     = {eng},
  number       = {8},
  pages        = {416--422},
  publisher    = {Informa Healthcare},
  series       = {Gynecological Endocrinology},
  title        = {Colorectal cancer in middle-aged women in relation to hormonal status: A report from the Women's Health in the Lund Area (WHILA) study.},
  url          = {http://dx.doi.org/10.1080/09513590600900378},
  doi          = {10.1080/09513590600900378},
  volume       = {22},
  year         = {2006},
}