Oats (Avena sativa) reduce atherogenesis in LDL-receptor-deficient mice.
(2010) In Atherosclerosis Jul 1. p.93-99- Abstract
- AIM: The cholesterol-lowering properties of oats, largely ascribed to its contents of soluble fibers, beta-glucans, are well established, whereas effects on atherogenesis are less well elucidated. Oats also contains components with reported antioxidant and anti-inflammatory effects that may affect atherogenesis. In this work we examined effects of oat bran on plasma cholesterol, markers of inflammation, eNOS expression and development of atherosclerosis in LDL-receptor-deficient (LDLr(-/-)) mice. METHODS AND RESULTS: Female LDLr(-/-) mice were fed Western diet+/-oat bran. Two concentrations of oat bran (40 and 27%) were compared regarding effects on plasma lipids. There was a dose-dependent reduction of plasma cholesterol by 42 and 20%... (More)
- AIM: The cholesterol-lowering properties of oats, largely ascribed to its contents of soluble fibers, beta-glucans, are well established, whereas effects on atherogenesis are less well elucidated. Oats also contains components with reported antioxidant and anti-inflammatory effects that may affect atherogenesis. In this work we examined effects of oat bran on plasma cholesterol, markers of inflammation, eNOS expression and development of atherosclerosis in LDL-receptor-deficient (LDLr(-/-)) mice. METHODS AND RESULTS: Female LDLr(-/-) mice were fed Western diet+/-oat bran. Two concentrations of oat bran (40 and 27%) were compared regarding effects on plasma lipids. There was a dose-dependent reduction of plasma cholesterol by 42 and 20% with 40 and 27% oat bran, respectively. Both concentrations also lowered plasma triglycerides (by 45 and 33%) and relative levels of plasma LDL+VLDL. The reduction of plasma lipids was accompanied by increased faecal excretion of cholesterol and bile acids. Oat bran (40%) efficiently reduced atherosclerotic lesion area in the descending aorta (-77%) and aortic root (-33%). Plasma levels of fibrinogen and soluble vascular cell adhesion molecule-1 (VCAM-1) were significantly lower, and immunofluorescence of aortic sections revealed a 75% lower expression of VCAM-1 in oat-fed mice. The expression of eNOS protein in the aortic wall was increased in mice fed oat bran. CONCLUSIONS: Oat bran supplemented to a Western diet lowers plasma cholesterol, reduces levels of some inflammatory markers, increases eNOS expression and inhibits atherosclerotic lesion development in LDLr(-/-) mice. It remains to be investigated which components in oats contribute to these effects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1625981
- author
- Andersson, Kristina E LU ; Svedberg, Kaj LU ; Lindholm, Marie LU ; Öste, Rickard LU and Hellstrand, Per LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Atherosclerosis
- volume
- Jul 1
- pages
- 93 - 99
- publisher
- Elsevier
- external identifiers
-
- wos:000281459900016
- pmid:20553794
- scopus:77956229175
- pmid:20553794
- ISSN
- 1879-1484
- DOI
- 10.1016/j.atherosclerosis.2010.05.001
- language
- English
- LU publication?
- yes
- id
- c65678ed-6569-4cb5-8929-ab97fecef38f (old id 1625981)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20553794?dopt=Abstract
- date added to LUP
- 2016-04-04 07:55:11
- date last changed
- 2022-01-29 02:49:01
@article{c65678ed-6569-4cb5-8929-ab97fecef38f,
abstract = {{AIM: The cholesterol-lowering properties of oats, largely ascribed to its contents of soluble fibers, beta-glucans, are well established, whereas effects on atherogenesis are less well elucidated. Oats also contains components with reported antioxidant and anti-inflammatory effects that may affect atherogenesis. In this work we examined effects of oat bran on plasma cholesterol, markers of inflammation, eNOS expression and development of atherosclerosis in LDL-receptor-deficient (LDLr(-/-)) mice. METHODS AND RESULTS: Female LDLr(-/-) mice were fed Western diet+/-oat bran. Two concentrations of oat bran (40 and 27%) were compared regarding effects on plasma lipids. There was a dose-dependent reduction of plasma cholesterol by 42 and 20% with 40 and 27% oat bran, respectively. Both concentrations also lowered plasma triglycerides (by 45 and 33%) and relative levels of plasma LDL+VLDL. The reduction of plasma lipids was accompanied by increased faecal excretion of cholesterol and bile acids. Oat bran (40%) efficiently reduced atherosclerotic lesion area in the descending aorta (-77%) and aortic root (-33%). Plasma levels of fibrinogen and soluble vascular cell adhesion molecule-1 (VCAM-1) were significantly lower, and immunofluorescence of aortic sections revealed a 75% lower expression of VCAM-1 in oat-fed mice. The expression of eNOS protein in the aortic wall was increased in mice fed oat bran. CONCLUSIONS: Oat bran supplemented to a Western diet lowers plasma cholesterol, reduces levels of some inflammatory markers, increases eNOS expression and inhibits atherosclerotic lesion development in LDLr(-/-) mice. It remains to be investigated which components in oats contribute to these effects.}},
author = {{Andersson, Kristina E and Svedberg, Kaj and Lindholm, Marie and Öste, Rickard and Hellstrand, Per}},
issn = {{1879-1484}},
language = {{eng}},
pages = {{93--99}},
publisher = {{Elsevier}},
series = {{Atherosclerosis}},
title = {{Oats (Avena sativa) reduce atherogenesis in LDL-receptor-deficient mice.}},
url = {{https://lup.lub.lu.se/search/files/5158506/1660527.pdf}},
doi = {{10.1016/j.atherosclerosis.2010.05.001}},
volume = {{Jul 1}},
year = {{2010}},
}