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Functional Variants of Fc Gamma Receptor (FCGR2A) and FCGR3A Are Not Associated with Susceptibility to Systemic Sclerosis in a Large European Study (EUSTAR).

Alizadeh, Behrooz Z; Broen, Jasper; Rueda, Blanca; Hesselstrand, Roger LU ; Wuttge, Dirk LU ; Simeon, Carmen; Ortego-Centeno, Norberto; Gonzalez-Gay, Miguel; Pros, Anna and Herrick, Ariane, et al. (2010) In Journal of Rheumatology Jul 1. p.1673-1679
Abstract
OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>C functional variants in 6 independent European cohorts of white patients with SSc, and white controls. The cohorts comprised 165 Dutch patients with SSc and 1326 controls, 236 Spanish patients with SSc and 257 controls, 267 German patients with SSc and 270 controls, 202 Swedish patients with SSc and 261 controls, 416 Italian patients... (More)
OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>C functional variants in 6 independent European cohorts of white patients with SSc, and white controls. The cohorts comprised 165 Dutch patients with SSc and 1326 controls, 236 Spanish patients with SSc and 257 controls, 267 German patients with SSc and 270 controls, 202 Swedish patients with SSc and 261 controls, 416 Italian patients with SSc and 157 controls, and additionally 280 English patients with SSc. Genotyping was performed using Taqman 5' allelic discrimination assay. The study reached a 99% power to detect the effect of a polymorphism at an OR of 1.3. RESULTS: Neither FCGR2A 519A>G nor FCGR3A 559A>C was significantly associated with susceptibility to SSc. We did not find an association with specific disease phenotypes, limited or diffuse cutaneous involvement, autoantibody profiles, or pulmonary involvement. CONCLUSION: Our study strongly suggests the lack of a role for the FCGR2A 519A>G and FCGR3A 559A>C polymorphisms in SSc susceptibility or clinical phenotype in 6 independent European cohorts. (Less)
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Journal of Rheumatology
volume
Jul 1
pages
1673 - 1679
publisher
J Rheumatol Publ Co
external identifiers
  • wos:000280860600018
  • pmid:20551103
  • scopus:77955500500
ISSN
0315-162X
DOI
10.3899/jrheum.091259
language
English
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yes
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9a1c1689-120f-45bb-828f-604faf16ce80 (old id 1626014)
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http://www.ncbi.nlm.nih.gov/pubmed/20551103?dopt=Abstract
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2010-07-05 20:07:16
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2018-05-29 11:24:54
@article{9a1c1689-120f-45bb-828f-604faf16ce80,
  abstract     = {OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>C functional variants in 6 independent European cohorts of white patients with SSc, and white controls. The cohorts comprised 165 Dutch patients with SSc and 1326 controls, 236 Spanish patients with SSc and 257 controls, 267 German patients with SSc and 270 controls, 202 Swedish patients with SSc and 261 controls, 416 Italian patients with SSc and 157 controls, and additionally 280 English patients with SSc. Genotyping was performed using Taqman 5' allelic discrimination assay. The study reached a 99% power to detect the effect of a polymorphism at an OR of 1.3. RESULTS: Neither FCGR2A 519A>G nor FCGR3A 559A>C was significantly associated with susceptibility to SSc. We did not find an association with specific disease phenotypes, limited or diffuse cutaneous involvement, autoantibody profiles, or pulmonary involvement. CONCLUSION: Our study strongly suggests the lack of a role for the FCGR2A 519A>G and FCGR3A 559A>C polymorphisms in SSc susceptibility or clinical phenotype in 6 independent European cohorts.},
  author       = {Alizadeh, Behrooz Z and Broen, Jasper and Rueda, Blanca and Hesselstrand, Roger and Wuttge, Dirk and Simeon, Carmen and Ortego-Centeno, Norberto and Gonzalez-Gay, Miguel and Pros, Anna and Herrick, Ariane and Worthington, Jane and Denton, Christopher and Fonseca, Carmen and Riemekasten, Gabriela and Vonk, Madelon C and van den Hoogen, Frank and Guiducci, Serena and Matucci-Cerinic, Marco and Scorza, Rafaella and Beretta, Lorenzo and Airó, Paolo and Coenen, Marieke and Martin, Javier and Koeleman, Bobby P C and Radstake, Timothy R D J},
  issn         = {0315-162X},
  language     = {eng},
  pages        = {1673--1679},
  publisher    = {J Rheumatol Publ Co},
  series       = {Journal of Rheumatology},
  title        = {Functional Variants of Fc Gamma Receptor (FCGR2A) and FCGR3A Are Not Associated with Susceptibility to Systemic Sclerosis in a Large European Study (EUSTAR).},
  url          = {http://dx.doi.org/10.3899/jrheum.091259},
  volume       = {Jul 1},
  year         = {2010},
}