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Cardiovascular risk factors regulate the expression of vascular endothelin receptors.

Xu, Cang-Bao LU ; Sun, Yang and Edvinsson, Lars LU (2010) In Pharmacology and Therapeutics Jul 1. p.148-155
Abstract
Cardiovascular disease remains as the leading cause of death in the developed world. However, there is limited knowledge about how cardiovascular risk factors actually cause vascular disease. Traditional cardiovascular risk factors include increased circulating levels of low-density lipoproteins, cigarette smoking and hypertension (both strongly related to arterial wall injury), inflammation and atherosclerosis. The vascular endothelin receptors are a protein family that belongs to the larger family of G-protein coupled receptors. They mediate vascular smooth muscle contraction, proliferation and apoptosis, which are important events in the pathogenesis of atherosclerotic vascular disease. Recent investigations into intracellular signaling... (More)
Cardiovascular disease remains as the leading cause of death in the developed world. However, there is limited knowledge about how cardiovascular risk factors actually cause vascular disease. Traditional cardiovascular risk factors include increased circulating levels of low-density lipoproteins, cigarette smoking and hypertension (both strongly related to arterial wall injury), inflammation and atherosclerosis. The vascular endothelin receptors are a protein family that belongs to the larger family of G-protein coupled receptors. They mediate vascular smooth muscle contraction, proliferation and apoptosis, which are important events in the pathogenesis of atherosclerotic vascular disease. Recent investigations into intracellular signaling mechanisms suggest that the above risk factors increase the expression of endothelin receptors in vascular smooth muscle cells by activating intracellular mitogen-activated protein kinase pathways and downstream transcription factors such as nuclear factor-kappaB. Understanding the mechanisms involved in vascular endothelin receptor upregulation during cardiovascular disease may provide novel therapeutic approaches. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pharmacology and Therapeutics
volume
Jul 1
pages
148 - 155
publisher
Elsevier
external identifiers
  • wos:000280384900005
  • pmid:20546781
  • scopus:77954213061
ISSN
0163-7258
DOI
10.1016/j.pharmthera.2010.04.013
language
English
LU publication?
yes
id
d5e23a79-e494-4e3e-8bc9-b84b67ea1fc1 (old id 1626083)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20546781?dopt=Abstract
date added to LUP
2010-07-05 20:19:00
date last changed
2018-05-29 10:29:41
@article{d5e23a79-e494-4e3e-8bc9-b84b67ea1fc1,
  abstract     = {Cardiovascular disease remains as the leading cause of death in the developed world. However, there is limited knowledge about how cardiovascular risk factors actually cause vascular disease. Traditional cardiovascular risk factors include increased circulating levels of low-density lipoproteins, cigarette smoking and hypertension (both strongly related to arterial wall injury), inflammation and atherosclerosis. The vascular endothelin receptors are a protein family that belongs to the larger family of G-protein coupled receptors. They mediate vascular smooth muscle contraction, proliferation and apoptosis, which are important events in the pathogenesis of atherosclerotic vascular disease. Recent investigations into intracellular signaling mechanisms suggest that the above risk factors increase the expression of endothelin receptors in vascular smooth muscle cells by activating intracellular mitogen-activated protein kinase pathways and downstream transcription factors such as nuclear factor-kappaB. Understanding the mechanisms involved in vascular endothelin receptor upregulation during cardiovascular disease may provide novel therapeutic approaches.},
  author       = {Xu, Cang-Bao and Sun, Yang and Edvinsson, Lars},
  issn         = {0163-7258},
  language     = {eng},
  pages        = {148--155},
  publisher    = {Elsevier},
  series       = {Pharmacology and Therapeutics},
  title        = {Cardiovascular risk factors regulate the expression of vascular endothelin receptors.},
  url          = {http://dx.doi.org/10.1016/j.pharmthera.2010.04.013},
  volume       = {Jul 1},
  year         = {2010},
}