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Nucleoside phosphorylases from clostridium perfringens in the synthesis of 2',3'-dideoxyinosine.

Christoffersen, Stig LU ; Serra, Immacolata LU ; Terreni, M and Piskur, Jure LU (2010) In Nucleosides, Nucleotides & Nucleic Acids 29(4-6). p.445-448
Abstract
Four Clostridium perfringens phosphorylases were subcloned, overexpressed and analyzed for their substrate specificity. DeoD(1) and PunA could use a variety of purine substrates, including an antiviral drug 2',3'-dideoxyinosine (ddI). In one-pot synthesis using Clostridium phosphorylases, 2',3'-dideoxyuridine and hypoxanthine were converted to ddI at yield of about 30%.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nucleosides, Nucleotides & Nucleic Acids
volume
29
issue
4-6
pages
445 - 448
publisher
Taylor & Francis
external identifiers
  • wos:000278713200031
  • scopus:77953692414
ISSN
1525-7770
DOI
10.1080/15257771003741422
language
English
LU publication?
yes
id
a225d8a3-cfad-451d-9b8e-bdcedd43db1b (old id 1626122)
date added to LUP
2010-09-03 12:44:16
date last changed
2018-05-29 11:44:25
@article{a225d8a3-cfad-451d-9b8e-bdcedd43db1b,
  abstract     = {Four Clostridium perfringens phosphorylases were subcloned, overexpressed and analyzed for their substrate specificity. DeoD(1) and PunA could use a variety of purine substrates, including an antiviral drug 2',3'-dideoxyinosine (ddI). In one-pot synthesis using Clostridium phosphorylases, 2',3'-dideoxyuridine and hypoxanthine were converted to ddI at yield of about 30%.},
  author       = {Christoffersen, Stig and Serra, Immacolata and Terreni, M and Piskur, Jure},
  issn         = {1525-7770},
  language     = {eng},
  number       = {4-6},
  pages        = {445--448},
  publisher    = {Taylor & Francis},
  series       = {Nucleosides, Nucleotides & Nucleic Acids},
  title        = {Nucleoside phosphorylases from clostridium perfringens in the synthesis of 2',3'-dideoxyinosine.},
  url          = {http://dx.doi.org/10.1080/15257771003741422},
  volume       = {29},
  year         = {2010},
}