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N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.

Johansson, Jenny LU ; Voss, Ulrikke LU ; Kesavan, Gokul LU ; Kostetskii, Igor ; Wierup, Nils LU ; Radice, Glenn L and Semb, Henrik LU (2010) In Genesis: The Journal of Genetics and Development 48(6). p.374-381
Abstract
The cadherin family of cell adhesion molecules mediates adhesive interactions that are required for the formation and maintenance of tissues. Previously, we demonstrated that N-cadherin, which is required for numerous morphogenetic processes, is expressed in the pancreatic epithelium at E9.5, but later becomes restricted to endocrine aggregates in mice. To study the role of N-cadherin during pancreas formation and function we generated a tissue-specific knockout of N-cadherin in the early pancreatic epithelium by inter-crossing N-cadherin-floxed mice with Pdx1Cre mice. Analysis of pancreas-specific ablation of N-cadherin demonstrates that N-cadherin is dispensable for pancreatic development, but required for beta-cell granule turnover. The... (More)
The cadherin family of cell adhesion molecules mediates adhesive interactions that are required for the formation and maintenance of tissues. Previously, we demonstrated that N-cadherin, which is required for numerous morphogenetic processes, is expressed in the pancreatic epithelium at E9.5, but later becomes restricted to endocrine aggregates in mice. To study the role of N-cadherin during pancreas formation and function we generated a tissue-specific knockout of N-cadherin in the early pancreatic epithelium by inter-crossing N-cadherin-floxed mice with Pdx1Cre mice. Analysis of pancreas-specific ablation of N-cadherin demonstrates that N-cadherin is dispensable for pancreatic development, but required for beta-cell granule turnover. The number of insulin secretory granules is significantly reduced in N-cadherin-deficient beta-cells, and as a consequence insulin secretion is decreased. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genesis: The Journal of Genetics and Development
volume
48
issue
6
pages
374 - 381
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000279030800004
  • pmid:20533404
  • scopus:77953510208
  • pmid:20533404
ISSN
1526-954X
DOI
10.1002/dvg.20628
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Stem Cell Center (013041110), Neuroendocrine Cell Biology (013212008)
id
b8f533ad-1eb4-4837-a5f3-488737a1bfb0 (old id 1626249)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20533404?dopt=Abstract
date added to LUP
2016-04-04 08:36:51
date last changed
2022-08-23 04:23:52
@article{b8f533ad-1eb4-4837-a5f3-488737a1bfb0,
  abstract     = {{The cadherin family of cell adhesion molecules mediates adhesive interactions that are required for the formation and maintenance of tissues. Previously, we demonstrated that N-cadherin, which is required for numerous morphogenetic processes, is expressed in the pancreatic epithelium at E9.5, but later becomes restricted to endocrine aggregates in mice. To study the role of N-cadherin during pancreas formation and function we generated a tissue-specific knockout of N-cadherin in the early pancreatic epithelium by inter-crossing N-cadherin-floxed mice with Pdx1Cre mice. Analysis of pancreas-specific ablation of N-cadherin demonstrates that N-cadherin is dispensable for pancreatic development, but required for beta-cell granule turnover. The number of insulin secretory granules is significantly reduced in N-cadherin-deficient beta-cells, and as a consequence insulin secretion is decreased.}},
  author       = {{Johansson, Jenny and Voss, Ulrikke and Kesavan, Gokul and Kostetskii, Igor and Wierup, Nils and Radice, Glenn L and Semb, Henrik}},
  issn         = {{1526-954X}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{374--381}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Genesis: The Journal of Genetics and Development}},
  title        = {{N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.}},
  url          = {{http://dx.doi.org/10.1002/dvg.20628}},
  doi          = {{10.1002/dvg.20628}},
  volume       = {{48}},
  year         = {{2010}},
}