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Changes in cardiac pumping efficiency and intra-thoracic organ volume during negative pressure wound therapy of sternotomy wounds, assessment using magnetic resonance imaging.

Torbrand, Christian LU ; Ugander, Martin LU ; Engblom, Henrik LU ; Olivecrona, Göran LU ; Gålne, Olof; Arheden, Håkan LU ; Ingemansson, Richard LU and Malmsjö, Malin LU (2010) In International Wound Journal 7(2). p.115-121
Abstract
Knowledge on the effects of negative pressure wound therapy (NPWT) on the intra-thoracic organs is limited. The present study was performed to investigate the effects of NPWT on the volume of the intra-thoracic organs, using magnetic resonance imaging (MRI), in a porcine sternotomy wound model. Six pigs underwent median sternotomy followed by NPWT at -75, -125 and -175 mmHg. Six pigs were not sternotomised. MR images covering the thorax and heart were acquired. The volumes of the thoracic cavity, lungs, wound fluid and heart were then determined. The volumes of the thoracic cavity and intra-thoracic organs increased after sternotomy and decreased upon NPWT application. The total heart volume variation, which is a measure of cardiac pumping... (More)
Knowledge on the effects of negative pressure wound therapy (NPWT) on the intra-thoracic organs is limited. The present study was performed to investigate the effects of NPWT on the volume of the intra-thoracic organs, using magnetic resonance imaging (MRI), in a porcine sternotomy wound model. Six pigs underwent median sternotomy followed by NPWT at -75, -125 and -175 mmHg. Six pigs were not sternotomised. MR images covering the thorax and heart were acquired. The volumes of the thoracic cavity, lungs, wound fluid and heart were then determined. The volumes of the thoracic cavity and intra-thoracic organs increased after sternotomy and decreased upon NPWT application. The total heart volume variation, which is a measure of cardiac pumping efficiency, was higher after sternotomy and decreased during NPWT. NPWT did not result in the evacuation of wound fluid from the bottom of the wound. NPWT largely closes and restores the thoracic cavity. Cardiac pumping efficiency returns to pre-sternotomy levels during NPWT. This may contribute to the clinical benefits of NPWT over open-chest care, including the stabilizing effects and the reduced need for mechanical ventilation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Wound Journal
volume
7
issue
2
pages
115 - 121
publisher
Wiley-Blackwell
external identifiers
  • wos:000287513600008
  • pmid:20529152
  • scopus:77951222423
ISSN
1742-481X
DOI
10.1111/j.1742-481X.2010.00664.x
language
English
LU publication?
yes
id
13665c55-a13f-4c0a-9fde-4e22c2d45df5 (old id 1626290)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20529152?dopt=Abstract
date added to LUP
2010-07-05 10:27:58
date last changed
2018-05-29 09:19:30
@article{13665c55-a13f-4c0a-9fde-4e22c2d45df5,
  abstract     = {Knowledge on the effects of negative pressure wound therapy (NPWT) on the intra-thoracic organs is limited. The present study was performed to investigate the effects of NPWT on the volume of the intra-thoracic organs, using magnetic resonance imaging (MRI), in a porcine sternotomy wound model. Six pigs underwent median sternotomy followed by NPWT at -75, -125 and -175 mmHg. Six pigs were not sternotomised. MR images covering the thorax and heart were acquired. The volumes of the thoracic cavity, lungs, wound fluid and heart were then determined. The volumes of the thoracic cavity and intra-thoracic organs increased after sternotomy and decreased upon NPWT application. The total heart volume variation, which is a measure of cardiac pumping efficiency, was higher after sternotomy and decreased during NPWT. NPWT did not result in the evacuation of wound fluid from the bottom of the wound. NPWT largely closes and restores the thoracic cavity. Cardiac pumping efficiency returns to pre-sternotomy levels during NPWT. This may contribute to the clinical benefits of NPWT over open-chest care, including the stabilizing effects and the reduced need for mechanical ventilation.},
  author       = {Torbrand, Christian and Ugander, Martin and Engblom, Henrik and Olivecrona, Göran and Gålne, Olof and Arheden, Håkan and Ingemansson, Richard and Malmsjö, Malin},
  issn         = {1742-481X},
  language     = {eng},
  number       = {2},
  pages        = {115--121},
  publisher    = {Wiley-Blackwell},
  series       = {International Wound Journal},
  title        = {Changes in cardiac pumping efficiency and intra-thoracic organ volume during negative pressure wound therapy of sternotomy wounds, assessment using magnetic resonance imaging.},
  url          = {http://dx.doi.org/10.1111/j.1742-481X.2010.00664.x},
  volume       = {7},
  year         = {2010},
}