Changes in cardiac pumping efficiency and intra-thoracic organ volume during negative pressure wound therapy of sternotomy wounds, assessment using magnetic resonance imaging.
(2010) In International Wound Journal 7(2). p.115-121- Abstract
- Knowledge on the effects of negative pressure wound therapy (NPWT) on the intra-thoracic organs is limited. The present study was performed to investigate the effects of NPWT on the volume of the intra-thoracic organs, using magnetic resonance imaging (MRI), in a porcine sternotomy wound model. Six pigs underwent median sternotomy followed by NPWT at -75, -125 and -175 mmHg. Six pigs were not sternotomised. MR images covering the thorax and heart were acquired. The volumes of the thoracic cavity, lungs, wound fluid and heart were then determined. The volumes of the thoracic cavity and intra-thoracic organs increased after sternotomy and decreased upon NPWT application. The total heart volume variation, which is a measure of cardiac pumping... (More)
- Knowledge on the effects of negative pressure wound therapy (NPWT) on the intra-thoracic organs is limited. The present study was performed to investigate the effects of NPWT on the volume of the intra-thoracic organs, using magnetic resonance imaging (MRI), in a porcine sternotomy wound model. Six pigs underwent median sternotomy followed by NPWT at -75, -125 and -175 mmHg. Six pigs were not sternotomised. MR images covering the thorax and heart were acquired. The volumes of the thoracic cavity, lungs, wound fluid and heart were then determined. The volumes of the thoracic cavity and intra-thoracic organs increased after sternotomy and decreased upon NPWT application. The total heart volume variation, which is a measure of cardiac pumping efficiency, was higher after sternotomy and decreased during NPWT. NPWT did not result in the evacuation of wound fluid from the bottom of the wound. NPWT largely closes and restores the thoracic cavity. Cardiac pumping efficiency returns to pre-sternotomy levels during NPWT. This may contribute to the clinical benefits of NPWT over open-chest care, including the stabilizing effects and the reduced need for mechanical ventilation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1626290
- author
- Torbrand, Christian LU ; Ugander, Martin LU ; Engblom, Henrik LU ; Olivecrona, Göran LU ; Gålne, Olof ; Arheden, Håkan LU ; Ingemansson, Richard LU and Malmsjö, Malin LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Wound Journal
- volume
- 7
- issue
- 2
- pages
- 115 - 121
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000287513600008
- pmid:20529152
- scopus:77951222423
- pmid:20529152
- ISSN
- 1742-481X
- DOI
- 10.1111/j.1742-481X.2010.00664.x
- language
- English
- LU publication?
- yes
- id
- 13665c55-a13f-4c0a-9fde-4e22c2d45df5 (old id 1626290)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20529152?dopt=Abstract
- date added to LUP
- 2016-04-04 07:26:39
- date last changed
- 2022-01-29 02:11:14
@article{13665c55-a13f-4c0a-9fde-4e22c2d45df5,
abstract = {{Knowledge on the effects of negative pressure wound therapy (NPWT) on the intra-thoracic organs is limited. The present study was performed to investigate the effects of NPWT on the volume of the intra-thoracic organs, using magnetic resonance imaging (MRI), in a porcine sternotomy wound model. Six pigs underwent median sternotomy followed by NPWT at -75, -125 and -175 mmHg. Six pigs were not sternotomised. MR images covering the thorax and heart were acquired. The volumes of the thoracic cavity, lungs, wound fluid and heart were then determined. The volumes of the thoracic cavity and intra-thoracic organs increased after sternotomy and decreased upon NPWT application. The total heart volume variation, which is a measure of cardiac pumping efficiency, was higher after sternotomy and decreased during NPWT. NPWT did not result in the evacuation of wound fluid from the bottom of the wound. NPWT largely closes and restores the thoracic cavity. Cardiac pumping efficiency returns to pre-sternotomy levels during NPWT. This may contribute to the clinical benefits of NPWT over open-chest care, including the stabilizing effects and the reduced need for mechanical ventilation.}},
author = {{Torbrand, Christian and Ugander, Martin and Engblom, Henrik and Olivecrona, Göran and Gålne, Olof and Arheden, Håkan and Ingemansson, Richard and Malmsjö, Malin}},
issn = {{1742-481X}},
language = {{eng}},
number = {{2}},
pages = {{115--121}},
publisher = {{Wiley-Blackwell}},
series = {{International Wound Journal}},
title = {{Changes in cardiac pumping efficiency and intra-thoracic organ volume during negative pressure wound therapy of sternotomy wounds, assessment using magnetic resonance imaging.}},
url = {{http://dx.doi.org/10.1111/j.1742-481X.2010.00664.x}},
doi = {{10.1111/j.1742-481X.2010.00664.x}},
volume = {{7}},
year = {{2010}},
}