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Male infertility and prostate cancer risk: a nested case-control study.

Ruhayel, Yasir LU ; Giwercman, Aleksander LU ; Ulmert, David LU ; Rylander, Lars LU ; Bjartell, Anders LU ; Manjer, Jonas LU ; Berglund, Göran LU and Giwercman, Yvonne LU (2010) In Cancer Causes and Control Jul 1. p.1635-1643
Abstract
The pathogenesis of prostate cancer is unclear, although experimental evidence implicates androgens as playing an important role. Infertile men frequently suffer from some degree of hypogonadism and may hence be hypothesized to be at lower risk of developing prostate cancer than fertile men. To test this hypothesis, we conducted a case-control study nested within "the Malmö Diet and Cancer Study" cohort in Sweden, inviting 661 prostate cancer cases and 661 age-matched controls to participate. Of the 975 (74%) respondents, we excluded 84 childless men with unknown fertility status. Thus, 891 men were included, providing 445 prostate cancer cases and 446 controls. Of these, 841 (94%) men were biological fathers and 50 (6%) men were... (More)
The pathogenesis of prostate cancer is unclear, although experimental evidence implicates androgens as playing an important role. Infertile men frequently suffer from some degree of hypogonadism and may hence be hypothesized to be at lower risk of developing prostate cancer than fertile men. To test this hypothesis, we conducted a case-control study nested within "the Malmö Diet and Cancer Study" cohort in Sweden, inviting 661 prostate cancer cases and 661 age-matched controls to participate. Of the 975 (74%) respondents, we excluded 84 childless men with unknown fertility status. Thus, 891 men were included, providing 445 prostate cancer cases and 446 controls. Of these, 841 (94%) men were biological fathers and 50 (6%) men were infertile. Logistic regression showed that the infertile men were at significantly lower risk of being diagnosed with prostate cancer than the fertile men (odds ratio, 0.45; 95% confidence interval, 0.25-0.83). Conditional and unconditional multivariate models, adjusting for socioeconomic, anthropometric, and health-status-related factors, provided similar estimates. We conclude that enduring male infertility is associated with a reduced prostate cancer risk, thus corroborating the theory that normal testicular function, and hence most probably sufficient steroidogenesis, is an important contributing factor to the later development of this malignancy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Causes and Control
volume
Jul 1
pages
1635 - 1643
publisher
Springer
external identifiers
  • wos:000281934800011
  • pmid:20524053
  • scopus:77956967455
ISSN
1573-7225
DOI
10.1007/s10552-010-9592-8
language
English
LU publication?
yes
id
a78d3652-b9e7-4b6c-9f9b-3d94f5f4fd23 (old id 1626352)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20524053?dopt=Abstract
date added to LUP
2010-07-05 09:46:46
date last changed
2018-06-10 04:48:35
@article{a78d3652-b9e7-4b6c-9f9b-3d94f5f4fd23,
  abstract     = {The pathogenesis of prostate cancer is unclear, although experimental evidence implicates androgens as playing an important role. Infertile men frequently suffer from some degree of hypogonadism and may hence be hypothesized to be at lower risk of developing prostate cancer than fertile men. To test this hypothesis, we conducted a case-control study nested within "the Malmö Diet and Cancer Study" cohort in Sweden, inviting 661 prostate cancer cases and 661 age-matched controls to participate. Of the 975 (74%) respondents, we excluded 84 childless men with unknown fertility status. Thus, 891 men were included, providing 445 prostate cancer cases and 446 controls. Of these, 841 (94%) men were biological fathers and 50 (6%) men were infertile. Logistic regression showed that the infertile men were at significantly lower risk of being diagnosed with prostate cancer than the fertile men (odds ratio, 0.45; 95% confidence interval, 0.25-0.83). Conditional and unconditional multivariate models, adjusting for socioeconomic, anthropometric, and health-status-related factors, provided similar estimates. We conclude that enduring male infertility is associated with a reduced prostate cancer risk, thus corroborating the theory that normal testicular function, and hence most probably sufficient steroidogenesis, is an important contributing factor to the later development of this malignancy.},
  author       = {Ruhayel, Yasir and Giwercman, Aleksander and Ulmert, David and Rylander, Lars and Bjartell, Anders and Manjer, Jonas and Berglund, Göran and Giwercman, Yvonne},
  issn         = {1573-7225},
  language     = {eng},
  pages        = {1635--1643},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Male infertility and prostate cancer risk: a nested case-control study.},
  url          = {http://dx.doi.org/10.1007/s10552-010-9592-8},
  volume       = {Jul 1},
  year         = {2010},
}