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Intraductal papillary mucinous neoplasms of the pancreas: diagnosis and management.

Liu, Dongbin LU ; Fei, Li; Werner Josefin, Björk and Andersson, Roland LU (2010) In European Journal of Gastroenterology and Hepathology Jul 1. p.1029-1038
Abstract
Intraductal papillary mucinous neoplasms (IPMNs), characterized by intraductal papillary growth and thick mucin secretion, have increasingly been recognized. Despite modern preoperative evaluation, major difficulties still remain in distinguishing malignant invasive types from benign IPMNs. Following a PubMed database search, all relevant abstracts and articles on IPMN published in English and Chinese were reviewed. Main-duct and the mixed type IPMNs carry a higher risk of malignancy as compared with branch-duct type IPMNs. Treatment of branch-duct type IPMNs remains controversial. Once operation is indicated, intraoperative frozen section of margins plays an important role in the decision concerning the extent and type of surgery.... (More)
Intraductal papillary mucinous neoplasms (IPMNs), characterized by intraductal papillary growth and thick mucin secretion, have increasingly been recognized. Despite modern preoperative evaluation, major difficulties still remain in distinguishing malignant invasive types from benign IPMNs. Following a PubMed database search, all relevant abstracts and articles on IPMN published in English and Chinese were reviewed. Main-duct and the mixed type IPMNs carry a higher risk of malignancy as compared with branch-duct type IPMNs. Treatment of branch-duct type IPMNs remains controversial. Once operation is indicated, intraoperative frozen section of margins plays an important role in the decision concerning the extent and type of surgery. Pancreatectomy, partly preserving both endocrine and exocrine pancreatic function, is advocated for most patients with IPMN, though total pancreatectomy may be necessary in some. Both for patients subjected to surgery and those only observed, IPMN patients need regular close follow-up to identify recurrence or progressive disease. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
European Journal of Gastroenterology and Hepathology
volume
Jul 1
pages
1029 - 1038
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000280604500001
  • pmid:20520560
  • scopus:77955469347
ISSN
1473-5687
DOI
10.1097/MEG.0b013e32833b00f9
language
English
LU publication?
yes
id
f1987e13-9135-46bb-9ef4-cc319e871be5 (old id 1626383)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20520560?dopt=Abstract
date added to LUP
2010-07-02 09:58:03
date last changed
2018-05-29 10:12:38
@article{f1987e13-9135-46bb-9ef4-cc319e871be5,
  abstract     = {Intraductal papillary mucinous neoplasms (IPMNs), characterized by intraductal papillary growth and thick mucin secretion, have increasingly been recognized. Despite modern preoperative evaluation, major difficulties still remain in distinguishing malignant invasive types from benign IPMNs. Following a PubMed database search, all relevant abstracts and articles on IPMN published in English and Chinese were reviewed. Main-duct and the mixed type IPMNs carry a higher risk of malignancy as compared with branch-duct type IPMNs. Treatment of branch-duct type IPMNs remains controversial. Once operation is indicated, intraoperative frozen section of margins plays an important role in the decision concerning the extent and type of surgery. Pancreatectomy, partly preserving both endocrine and exocrine pancreatic function, is advocated for most patients with IPMN, though total pancreatectomy may be necessary in some. Both for patients subjected to surgery and those only observed, IPMN patients need regular close follow-up to identify recurrence or progressive disease.},
  author       = {Liu, Dongbin and Fei, Li and Werner Josefin, Björk and Andersson, Roland},
  issn         = {1473-5687},
  language     = {eng},
  pages        = {1029--1038},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Gastroenterology and Hepathology},
  title        = {Intraductal papillary mucinous neoplasms of the pancreas: diagnosis and management.},
  url          = {http://dx.doi.org/10.1097/MEG.0b013e32833b00f9},
  volume       = {Jul 1},
  year         = {2010},
}