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Influence of Salt on the Self-Assembly of Two Model Amyloid Heptapeptides

Castelletto, V. ; Hamley, I. W. ; Cenker, Celen LU and Olsson, Ulf LU (2010) In The Journal of Physical Chemistry Part B 114(23). p.8002-8008
Abstract
We study the effects of NaCl on the self-assembly of AAKLVFF and beta A beta AKLVFF in solution. Both AAKLVFF and beta A beta AKLVFF self-assemble into twisted fibers in aqueous solution. The addition of NaCl to aqueous solutions of AAKLVFF produces large crystal-like nanotapes which eventually precipitate. In contrast, highly twisted fibrils were observed for beta A beta AKLVFF solutions at low salt concentration, while a coexistence of highly twisted fibers and nanotubes was observed for beta A beta AKLVFF at high salt concentration. The self-assembled structures observed for beta A beta AKLVFF in NaCl solutions were ascribed to the progressive screening of the beta A beta AKLVFF surface charge caused by the addition of salt.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of Physical Chemistry Part B
volume
114
issue
23
pages
8002 - 8008
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000278479900035
  • scopus:77953420989
  • pmid:20496898
ISSN
1520-5207
DOI
10.1021/jp102744g
language
English
LU publication?
yes
id
c22f34ed-ea33-4a94-a0c3-66d231df34b7 (old id 1630957)
date added to LUP
2016-04-01 12:51:29
date last changed
2022-04-06 01:10:57
@article{c22f34ed-ea33-4a94-a0c3-66d231df34b7,
  abstract     = {{We study the effects of NaCl on the self-assembly of AAKLVFF and beta A beta AKLVFF in solution. Both AAKLVFF and beta A beta AKLVFF self-assemble into twisted fibers in aqueous solution. The addition of NaCl to aqueous solutions of AAKLVFF produces large crystal-like nanotapes which eventually precipitate. In contrast, highly twisted fibrils were observed for beta A beta AKLVFF solutions at low salt concentration, while a coexistence of highly twisted fibers and nanotubes was observed for beta A beta AKLVFF at high salt concentration. The self-assembled structures observed for beta A beta AKLVFF in NaCl solutions were ascribed to the progressive screening of the beta A beta AKLVFF surface charge caused by the addition of salt.}},
  author       = {{Castelletto, V. and Hamley, I. W. and Cenker, Celen and Olsson, Ulf}},
  issn         = {{1520-5207}},
  language     = {{eng}},
  number       = {{23}},
  pages        = {{8002--8008}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{The Journal of Physical Chemistry Part B}},
  title        = {{Influence of Salt on the Self-Assembly of Two Model Amyloid Heptapeptides}},
  url          = {{http://dx.doi.org/10.1021/jp102744g}},
  doi          = {{10.1021/jp102744g}},
  volume       = {{114}},
  year         = {{2010}},
}