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Influence of Salt on the Self-Assembly of Two Model Amyloid Heptapeptides

Castelletto, V.; Hamley, I. W.; Cenker, Celen LU and Olsson, Ulf LU (2010) In The Journal of Physical Chemistry Part B 114(23). p.8002-8008
Abstract
We study the effects of NaCl on the self-assembly of AAKLVFF and beta A beta AKLVFF in solution. Both AAKLVFF and beta A beta AKLVFF self-assemble into twisted fibers in aqueous solution. The addition of NaCl to aqueous solutions of AAKLVFF produces large crystal-like nanotapes which eventually precipitate. In contrast, highly twisted fibrils were observed for beta A beta AKLVFF solutions at low salt concentration, while a coexistence of highly twisted fibers and nanotubes was observed for beta A beta AKLVFF at high salt concentration. The self-assembled structures observed for beta A beta AKLVFF in NaCl solutions were ascribed to the progressive screening of the beta A beta AKLVFF surface charge caused by the addition of salt.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of Physical Chemistry Part B
volume
114
issue
23
pages
8002 - 8008
publisher
The American Chemical Society
external identifiers
  • wos:000278479900035
  • scopus:77953420989
ISSN
1520-5207
DOI
10.1021/jp102744g
language
English
LU publication?
yes
id
c22f34ed-ea33-4a94-a0c3-66d231df34b7 (old id 1630957)
date added to LUP
2010-07-22 13:36:16
date last changed
2018-05-29 12:14:22
@article{c22f34ed-ea33-4a94-a0c3-66d231df34b7,
  abstract     = {We study the effects of NaCl on the self-assembly of AAKLVFF and beta A beta AKLVFF in solution. Both AAKLVFF and beta A beta AKLVFF self-assemble into twisted fibers in aqueous solution. The addition of NaCl to aqueous solutions of AAKLVFF produces large crystal-like nanotapes which eventually precipitate. In contrast, highly twisted fibrils were observed for beta A beta AKLVFF solutions at low salt concentration, while a coexistence of highly twisted fibers and nanotubes was observed for beta A beta AKLVFF at high salt concentration. The self-assembled structures observed for beta A beta AKLVFF in NaCl solutions were ascribed to the progressive screening of the beta A beta AKLVFF surface charge caused by the addition of salt.},
  author       = {Castelletto, V. and Hamley, I. W. and Cenker, Celen and Olsson, Ulf},
  issn         = {1520-5207},
  language     = {eng},
  number       = {23},
  pages        = {8002--8008},
  publisher    = {The American Chemical Society},
  series       = {The Journal of Physical Chemistry Part B},
  title        = {Influence of Salt on the Self-Assembly of Two Model Amyloid Heptapeptides},
  url          = {http://dx.doi.org/10.1021/jp102744g},
  volume       = {114},
  year         = {2010},
}