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The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes

Abdul-Ghani, Muhammad A.; Lyssenko, Valeriya LU ; Tuomi, Tiinamaija LU ; DeFronzo, Ralph A. and Groop, Leif LU (2010) In Diabetes/Metabolism Research Reviews 26(4). p.280-286
Abstract
Background The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. Methods 2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. Results NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during... (More)
Background The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. Methods 2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. Results NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during oGrr had greater insulin sensitivity, better beta cell function and lower risk for future T2DM. Conclusions These data suggest that the shape of glucose curve can be utilized to assess future risk for T2DM. Copyright (C) 2010 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
shape of glucose tolerance curve, prediction of diabetes, OGTT
in
Diabetes/Metabolism Research Reviews
volume
26
issue
4
pages
280 - 286
publisher
John Wiley & Sons
external identifiers
  • wos:000278660400007
  • scopus:77952748876
ISSN
1520-7552
DOI
10.1002/dmrr.1084
language
English
LU publication?
yes
id
ff5f9428-b66b-4a7c-a7d8-a7e6608ce782 (old id 1631416)
date added to LUP
2010-07-21 12:13:33
date last changed
2018-07-01 03:20:22
@article{ff5f9428-b66b-4a7c-a7d8-a7e6608ce782,
  abstract     = {Background The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. Methods 2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. Results NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during oGrr had greater insulin sensitivity, better beta cell function and lower risk for future T2DM. Conclusions These data suggest that the shape of glucose curve can be utilized to assess future risk for T2DM. Copyright (C) 2010 John Wiley & Sons, Ltd.},
  author       = {Abdul-Ghani, Muhammad A. and Lyssenko, Valeriya and Tuomi, Tiinamaija and DeFronzo, Ralph A. and Groop, Leif},
  issn         = {1520-7552},
  keyword      = {shape of glucose tolerance curve,prediction of diabetes,OGTT},
  language     = {eng},
  number       = {4},
  pages        = {280--286},
  publisher    = {John Wiley & Sons},
  series       = {Diabetes/Metabolism Research Reviews},
  title        = {The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes},
  url          = {http://dx.doi.org/10.1002/dmrr.1084},
  volume       = {26},
  year         = {2010},
}