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Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations

Toft, Gunnar; Thulstrup, Ane M.; Jönsson, Bo A LU ; Pedersen, Henning S.; Ludwicki, Jan K.; Zvezday, Valentyna and Bonde, Jens P. (2010) In Environmental Health 9.
Abstract
Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p, p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland. Results: In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p, p'-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153>200 ng/g lipid compared to 0-25 ng CB-153/g... (More)
Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p, p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland. Results: In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p, p'-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153>200 ng/g lipid compared to 0-25 ng CB-153/g lipid and OR of 2.5 CI (0.9-6.6) for p, p'-DDE>1500 ng/g lipid compared to 0-250 ng DDE/g lipid. However, no clear dose response associations were observed. The results further suggest that high level of organochlorine serum concentrations may be related to repeated loss. Conclusions: The risk of fetal loss may increase at higher levels of CB-153 and p, p'-DDE exposure, although lack of dose response and inconsistencies between countries did not allow for firm conclusions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Health
volume
9
publisher
BioMed Central
external identifiers
  • wos:000278269300001
  • scopus:77951957462
ISSN
1476-069X
DOI
10.1186/1476-069X-9-22
language
English
LU publication?
yes
id
be926d03-253c-4c66-a2a6-4b1a3344b96d (old id 1632235)
date added to LUP
2010-07-21 09:56:31
date last changed
2018-05-29 11:08:50
@article{be926d03-253c-4c66-a2a6-4b1a3344b96d,
  abstract     = {Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p, p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland. Results: In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p, p'-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153>200 ng/g lipid compared to 0-25 ng CB-153/g lipid and OR of 2.5 CI (0.9-6.6) for p, p'-DDE>1500 ng/g lipid compared to 0-250 ng DDE/g lipid. However, no clear dose response associations were observed. The results further suggest that high level of organochlorine serum concentrations may be related to repeated loss. Conclusions: The risk of fetal loss may increase at higher levels of CB-153 and p, p'-DDE exposure, although lack of dose response and inconsistencies between countries did not allow for firm conclusions.},
  author       = {Toft, Gunnar and Thulstrup, Ane M. and Jönsson, Bo A and Pedersen, Henning S. and Ludwicki, Jan K. and Zvezday, Valentyna and Bonde, Jens P.},
  issn         = {1476-069X},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Environmental Health},
  title        = {Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations},
  url          = {http://dx.doi.org/10.1186/1476-069X-9-22},
  volume       = {9},
  year         = {2010},
}