Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations
(2010) In Environmental Health 9.- Abstract
- Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p, p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland. Results: In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p, p'-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153>200 ng/g lipid compared to 0-25 ng CB-153/g... (More)
- Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p, p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland. Results: In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p, p'-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153>200 ng/g lipid compared to 0-25 ng CB-153/g lipid and OR of 2.5 CI (0.9-6.6) for p, p'-DDE>1500 ng/g lipid compared to 0-250 ng DDE/g lipid. However, no clear dose response associations were observed. The results further suggest that high level of organochlorine serum concentrations may be related to repeated loss. Conclusions: The risk of fetal loss may increase at higher levels of CB-153 and p, p'-DDE exposure, although lack of dose response and inconsistencies between countries did not allow for firm conclusions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1632235
- author
- Toft, Gunnar ; Thulstrup, Ane M. ; Jönsson, Bo A LU ; Pedersen, Henning S. ; Ludwicki, Jan K. ; Zvezday, Valentyna and Bonde, Jens P.
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Environmental Health
- volume
- 9
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000278269300001
- scopus:77951957462
- pmid:20459724
- ISSN
- 1476-069X
- DOI
- 10.1186/1476-069X-9-22
- language
- English
- LU publication?
- yes
- id
- be926d03-253c-4c66-a2a6-4b1a3344b96d (old id 1632235)
- date added to LUP
- 2016-04-01 12:56:34
- date last changed
- 2025-04-04 15:22:24
@article{be926d03-253c-4c66-a2a6-4b1a3344b96d,
abstract = {{Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p, p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland. Results: In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p, p'-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153>200 ng/g lipid compared to 0-25 ng CB-153/g lipid and OR of 2.5 CI (0.9-6.6) for p, p'-DDE>1500 ng/g lipid compared to 0-250 ng DDE/g lipid. However, no clear dose response associations were observed. The results further suggest that high level of organochlorine serum concentrations may be related to repeated loss. Conclusions: The risk of fetal loss may increase at higher levels of CB-153 and p, p'-DDE exposure, although lack of dose response and inconsistencies between countries did not allow for firm conclusions.}},
author = {{Toft, Gunnar and Thulstrup, Ane M. and Jönsson, Bo A and Pedersen, Henning S. and Ludwicki, Jan K. and Zvezday, Valentyna and Bonde, Jens P.}},
issn = {{1476-069X}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{Environmental Health}},
title = {{Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations}},
url = {{http://dx.doi.org/10.1186/1476-069X-9-22}},
doi = {{10.1186/1476-069X-9-22}},
volume = {{9}},
year = {{2010}},
}