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Simulations of Osmotic Ultrafiltration Failure in CAPD Using a Serial Three-Pore Membrane/Fiber Matrix Model.

Rippe, Bengt LU and Venturoli, Daniele LU (2007) In American Journal of Physiology: Renal, Fluid and Electrolyte Physiology 292(3). p.1035-1043
Abstract
Ultrafiltration failure ( UFF) is a common complication of long- term peritoneal dialysis ( PD). Functionally UFF is in most cases characterized by an enhanced peritoneal mass transfer area coefficient for glucose ( PSg) combined with a largely unchanged peritoneal glucose osmotic conductance ( LpS sigma(g)). Morphologically, marked UFF occurs with fibrosis of the submesothelial zone in the peritoneum, combined with vasculopathy and vascular proliferation in deeper tissues. To computer simulate UFF, changes both in the vasculature and in the interstitium have to be taken into account. For that purpose, we used a three-pore membrane/ fiber matrix serial barrier model, applying the three-pore model to the capillaries and the fiber- matrix... (More)
Ultrafiltration failure ( UFF) is a common complication of long- term peritoneal dialysis ( PD). Functionally UFF is in most cases characterized by an enhanced peritoneal mass transfer area coefficient for glucose ( PSg) combined with a largely unchanged peritoneal glucose osmotic conductance ( LpS sigma(g)). Morphologically, marked UFF occurs with fibrosis of the submesothelial zone in the peritoneum, combined with vasculopathy and vascular proliferation in deeper tissues. To computer simulate UFF, changes both in the vasculature and in the interstitium have to be taken into account. For that purpose, we used a three-pore membrane/ fiber matrix serial barrier model, applying the three-pore model to the capillaries and the fiber- matrix model to the interstitium. The parameters of the three- pore model have been published previously. The interstitial fiber density was set at 0.5% ( vol/ vol) and the fiber radius ( r(f)) at 6 A during control. If the interstitial fiber density was increased from 0.5 to 3%, and r(f) to 7.5 angstrom ( cf. collagen) while the capillary surface area was increased by 40% from control, then PSg increased from 9.3 to 11.5 ml/ min, while the UF coefficient ( LpS) was largely unchanged. Further increases in vascular surface area combined with further increases in fiber density caused further increments in PSg, whereas LpS remained unchanged. It is concluded that a matrix of fibers coupled in series with a three- pore membrane may be used for simulating the pathophysiological alterations occurring in the peritoneum in UFF, explaining the commonly observed " uncoupling" of small solute transport ( PS) from the peritoneal UF coefficient ( LpS) in this condition. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
American Journal of Physiology: Renal, Fluid and Electrolyte Physiology
volume
292
issue
3
pages
1035 - 1043
publisher
American Physiological Society
external identifiers
  • wos:000244722300016
  • scopus:33847791588
ISSN
0363-6127
DOI
10.1152/ajprenal.00251.2006
language
English
LU publication?
yes
id
f6437d0d-449e-47c7-8bed-17e92b3d80a8 (old id 163386)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17090782&dopt=Abstract
date added to LUP
2007-07-10 11:46:51
date last changed
2017-09-17 04:29:34
@article{f6437d0d-449e-47c7-8bed-17e92b3d80a8,
  abstract     = {Ultrafiltration failure ( UFF) is a common complication of long- term peritoneal dialysis ( PD). Functionally UFF is in most cases characterized by an enhanced peritoneal mass transfer area coefficient for glucose ( PSg) combined with a largely unchanged peritoneal glucose osmotic conductance ( LpS sigma(g)). Morphologically, marked UFF occurs with fibrosis of the submesothelial zone in the peritoneum, combined with vasculopathy and vascular proliferation in deeper tissues. To computer simulate UFF, changes both in the vasculature and in the interstitium have to be taken into account. For that purpose, we used a three-pore membrane/ fiber matrix serial barrier model, applying the three-pore model to the capillaries and the fiber- matrix model to the interstitium. The parameters of the three- pore model have been published previously. The interstitial fiber density was set at 0.5% ( vol/ vol) and the fiber radius ( r(f)) at 6 A during control. If the interstitial fiber density was increased from 0.5 to 3%, and r(f) to 7.5 angstrom ( cf. collagen) while the capillary surface area was increased by 40% from control, then PSg increased from 9.3 to 11.5 ml/ min, while the UF coefficient ( LpS) was largely unchanged. Further increases in vascular surface area combined with further increases in fiber density caused further increments in PSg, whereas LpS remained unchanged. It is concluded that a matrix of fibers coupled in series with a three- pore membrane may be used for simulating the pathophysiological alterations occurring in the peritoneum in UFF, explaining the commonly observed " uncoupling" of small solute transport ( PS) from the peritoneal UF coefficient ( LpS) in this condition.},
  author       = {Rippe, Bengt and Venturoli, Daniele},
  issn         = {0363-6127},
  language     = {eng},
  number       = {3},
  pages        = {1035--1043},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology: Renal, Fluid and Electrolyte Physiology},
  title        = {Simulations of Osmotic Ultrafiltration Failure in CAPD Using a Serial Three-Pore Membrane/Fiber Matrix Model.},
  url          = {http://dx.doi.org/10.1152/ajprenal.00251.2006},
  volume       = {292},
  year         = {2007},
}