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Is it possible to improve the patch-test diagnostics for isocyanates? A stability study of petrolatum preparations of diphenylmethane-4,4'-diisocyanate and polymeric diphenylmethane diisocyanate.

Engfeldt, Malin LU ; Zimerson, Erik LU ; Karlsson, Daniel; Skarping, Gunnar LU ; Isaksson, Marléne LU and Bruze, Magnus LU (2007) In Contact Dermatitis 56(1). p.27-34
Abstract
We have previously shown that the concentration of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in commercial test preparations was so low that patch testing with the same was not reliable. The stability of 4,4'-MDI in petrolatum (pet.) was compared with pet. preparations of polymeric diphenylmethane diisocyanate (PMDI), which consists of a complex mixture of monomeric isomers and oligomers of MDI. Preparations of 4,4'-MDI and PMDI were stored under 3 different conditions, i.e. at room temperature, refrigerated and frozen. They were analysed continuously during 1 year with regard to the content of 4,4'-MDI, 3-ring oligomers and 4-ring oligomers using liquid chromatography-mass spectrometry. PMDI preparations kept frozen were stable for a... (More)
We have previously shown that the concentration of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in commercial test preparations was so low that patch testing with the same was not reliable. The stability of 4,4'-MDI in petrolatum (pet.) was compared with pet. preparations of polymeric diphenylmethane diisocyanate (PMDI), which consists of a complex mixture of monomeric isomers and oligomers of MDI. Preparations of 4,4'-MDI and PMDI were stored under 3 different conditions, i.e. at room temperature, refrigerated and frozen. They were analysed continuously during 1 year with regard to the content of 4,4'-MDI, 3-ring oligomers and 4-ring oligomers using liquid chromatography-mass spectrometry. PMDI preparations kept frozen were stable for a year. All other preparations failed to fulfil the requirements of stability, i.e. +/- 20% of the initial concentration. Storage in a freezer prolonged the lifetime for 4,4'-MDI. The decrease in concentration for preparations kept at room temperature and refrigerated was less rapid in PMDI preparations than in 4,4'-MDI preparations. PMDI preparations are better suited for patch testing patients exposed to MDI because they are more stable and homogeneous than 4,4'-MDI preparations. They better reflect possible allergens that workers are exposed to because products used in industry contain both monomers and oligomers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CAS 9016-87-9, contact dermatitis, CAS 101-68-8, stability, polyurethane, polymeric MDI, PMDI, patch, test preparation, diphenylmethane-4
in
Contact Dermatitis
volume
56
issue
1
pages
27 - 34
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:33845543893
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2007.01007.x
language
English
LU publication?
yes
id
91d1f30f-e1eb-4b94-a4f6-f99637fabf42 (old id 163916)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17177706&dopt=Abstract
date added to LUP
2007-07-19 12:41:48
date last changed
2017-09-17 05:21:39
@article{91d1f30f-e1eb-4b94-a4f6-f99637fabf42,
  abstract     = {We have previously shown that the concentration of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in commercial test preparations was so low that patch testing with the same was not reliable. The stability of 4,4'-MDI in petrolatum (pet.) was compared with pet. preparations of polymeric diphenylmethane diisocyanate (PMDI), which consists of a complex mixture of monomeric isomers and oligomers of MDI. Preparations of 4,4'-MDI and PMDI were stored under 3 different conditions, i.e. at room temperature, refrigerated and frozen. They were analysed continuously during 1 year with regard to the content of 4,4'-MDI, 3-ring oligomers and 4-ring oligomers using liquid chromatography-mass spectrometry. PMDI preparations kept frozen were stable for a year. All other preparations failed to fulfil the requirements of stability, i.e. +/- 20% of the initial concentration. Storage in a freezer prolonged the lifetime for 4,4'-MDI. The decrease in concentration for preparations kept at room temperature and refrigerated was less rapid in PMDI preparations than in 4,4'-MDI preparations. PMDI preparations are better suited for patch testing patients exposed to MDI because they are more stable and homogeneous than 4,4'-MDI preparations. They better reflect possible allergens that workers are exposed to because products used in industry contain both monomers and oligomers.},
  author       = {Engfeldt, Malin and Zimerson, Erik and Karlsson, Daniel and Skarping, Gunnar and Isaksson, Marléne and Bruze, Magnus},
  issn         = {0105-1873},
  keyword      = {CAS 9016-87-9,contact dermatitis,CAS 101-68-8,stability,polyurethane,polymeric MDI,PMDI,patch,test preparation,diphenylmethane-4},
  language     = {eng},
  number       = {1},
  pages        = {27--34},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Is it possible to improve the patch-test diagnostics for isocyanates? A stability study of petrolatum preparations of diphenylmethane-4,4'-diisocyanate and polymeric diphenylmethane diisocyanate.},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2007.01007.x},
  volume       = {56},
  year         = {2007},
}