Advanced

Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone.

Hansén Nord, Karolin LU ; Heidenblad, Markus LU ; Brosjo, Otte; Mandahl, Nils LU and Mertens, Fredrik LU (2007) In Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00 172(1). p.80-83
Abstract
Fibrosarcoma of bone is a rare malignant tumor accounting for less than 5% of all primary malignant bone neoplasms. There is very limited knowledge regarding the molecular genetics of this tumor, and there are no cytogenetic data available. In the present study, a fibrosarcoma deriving from the left iliac bone of a 10-year-old girl was characterized using cytogenetics, fluorescence in situ hybridization (FISH), and whole genome tiling resolution array comparative genomic hybridization (CGH). Cytogenetic and FISH analyses revealed a ring chromosome 6 as the sole acquired aberration, a finding corroborated by array CGH. The ring formation, however, did not result in any gain of genetic material. Nor did the breakpoints in 6p25 and 6q14 seem... (More)
Fibrosarcoma of bone is a rare malignant tumor accounting for less than 5% of all primary malignant bone neoplasms. There is very limited knowledge regarding the molecular genetics of this tumor, and there are no cytogenetic data available. In the present study, a fibrosarcoma deriving from the left iliac bone of a 10-year-old girl was characterized using cytogenetics, fluorescence in situ hybridization (FISH), and whole genome tiling resolution array comparative genomic hybridization (CGH). Cytogenetic and FISH analyses revealed a ring chromosome 6 as the sole acquired aberration, a finding corroborated by array CGH. The ring formation, however, did not result in any gain of genetic material. Nor did the breakpoints in 6p25 and 6q14 seem to affect any known gene loci in such a way that the ring formation could have resulted in the creation of a fusion gene or in the exchange of regulatory sequences. Thus, a reasonable interpretation of the pathogenetic significance of the ring formation would be that it resulted in the loss of one or more putative tumor suppressor gene loci distal to the two breakpoints. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00
volume
172
issue
1
pages
80 - 83
publisher
Elsevier
external identifiers
  • wos:000243296500014
  • scopus:33845460120
ISSN
0165-4608
DOI
10.1016/j.cancergencyto.2006.08.007
language
English
LU publication?
yes
id
db8a36f2-ae3c-4d80-a2e7-72937c99dc73 (old id 163957)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17175386&dopt=Abstract
date added to LUP
2007-07-06 14:56:17
date last changed
2017-01-01 07:18:15
@article{db8a36f2-ae3c-4d80-a2e7-72937c99dc73,
  abstract     = {Fibrosarcoma of bone is a rare malignant tumor accounting for less than 5% of all primary malignant bone neoplasms. There is very limited knowledge regarding the molecular genetics of this tumor, and there are no cytogenetic data available. In the present study, a fibrosarcoma deriving from the left iliac bone of a 10-year-old girl was characterized using cytogenetics, fluorescence in situ hybridization (FISH), and whole genome tiling resolution array comparative genomic hybridization (CGH). Cytogenetic and FISH analyses revealed a ring chromosome 6 as the sole acquired aberration, a finding corroborated by array CGH. The ring formation, however, did not result in any gain of genetic material. Nor did the breakpoints in 6p25 and 6q14 seem to affect any known gene loci in such a way that the ring formation could have resulted in the creation of a fusion gene or in the exchange of regulatory sequences. Thus, a reasonable interpretation of the pathogenetic significance of the ring formation would be that it resulted in the loss of one or more putative tumor suppressor gene loci distal to the two breakpoints.},
  author       = {Hansén Nord, Karolin and Heidenblad, Markus and Brosjo, Otte and Mandahl, Nils and Mertens, Fredrik},
  issn         = {0165-4608},
  language     = {eng},
  number       = {1},
  pages        = {80--83},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00},
  title        = {Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone.},
  url          = {http://dx.doi.org/10.1016/j.cancergencyto.2006.08.007},
  volume       = {172},
  year         = {2007},
}