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Orexin and psychiatric symptoms in suicide attempters.

Brundin, Lena LU ; Petersén, Åsa LU ; Björkqvist, Maria LU and Träskman Bendz, Lil LU (2007) In Journal of Affective Disorders 100(1-3). p.259-263
Abstract
BACKGROUND: The orexins (hypocretins) are recently discovered hypothalamic peptides that are involved in the regulation of sleep, appetite and state of arousal. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symptoms in suicidal patients. METHODS: A total of 101 patients were enrolled in the study shortly after a suicide attempt. All patients underwent a lumbar puncture after a wash-out period during which they did not receive any antipsychotic or antidepressive medication. Structured interviews were performed using the Comprehensive Psychopathological Rating Scale (CPRS). CSF-orexin-A was measured and correlated with ratings of psychiatric symptoms. RESULTS: There... (More)
BACKGROUND: The orexins (hypocretins) are recently discovered hypothalamic peptides that are involved in the regulation of sleep, appetite and state of arousal. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symptoms in suicidal patients. METHODS: A total of 101 patients were enrolled in the study shortly after a suicide attempt. All patients underwent a lumbar puncture after a wash-out period during which they did not receive any antipsychotic or antidepressive medication. Structured interviews were performed using the Comprehensive Psychopathological Rating Scale (CPRS). CSF-orexin-A was measured and correlated with ratings of psychiatric symptoms. RESULTS: There were significant and negative correlations between CSF-orexin and the symptoms lassitude (difficulty to initiate activities) and slowness of movement, as well as the ratings of global illness (p<0.005 for all three items, Spearman's rho). LIMITATIONS: Correlation analysis is an indirect method of investigation and does not demonstrate causal relationships. CONCLUSION: Low CSF-orexin levels are related to pronounced symptoms of inertia and reduced motor activity in suicidal patients. Interestingly, the lower the orexin levels, the higher were ratings of overall illness, as observed by a specialist in psychiatry. Our results suggest that reduced orexin levels are involved in the etiology of specific psychiatric symptoms. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Orexin, Movement, Depression, Suicide, Behaviour
in
Journal of Affective Disorders
volume
100
issue
1-3
pages
259 - 263
publisher
Elsevier
external identifiers
  • wos:000247704400032
  • scopus:34249324048
ISSN
1573-2517
DOI
10.1016/j.jad.2006.10.019
language
English
LU publication?
yes
id
914e4355-5d67-4056-bc55-f028f52b2254 (old id 164207)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17141878&dopt=Abstract
date added to LUP
2007-07-11 08:51:30
date last changed
2017-06-18 03:39:07
@article{914e4355-5d67-4056-bc55-f028f52b2254,
  abstract     = {BACKGROUND: The orexins (hypocretins) are recently discovered hypothalamic peptides that are involved in the regulation of sleep, appetite and state of arousal. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symptoms in suicidal patients. METHODS: A total of 101 patients were enrolled in the study shortly after a suicide attempt. All patients underwent a lumbar puncture after a wash-out period during which they did not receive any antipsychotic or antidepressive medication. Structured interviews were performed using the Comprehensive Psychopathological Rating Scale (CPRS). CSF-orexin-A was measured and correlated with ratings of psychiatric symptoms. RESULTS: There were significant and negative correlations between CSF-orexin and the symptoms lassitude (difficulty to initiate activities) and slowness of movement, as well as the ratings of global illness (p&lt;0.005 for all three items, Spearman's rho). LIMITATIONS: Correlation analysis is an indirect method of investigation and does not demonstrate causal relationships. CONCLUSION: Low CSF-orexin levels are related to pronounced symptoms of inertia and reduced motor activity in suicidal patients. Interestingly, the lower the orexin levels, the higher were ratings of overall illness, as observed by a specialist in psychiatry. Our results suggest that reduced orexin levels are involved in the etiology of specific psychiatric symptoms.},
  author       = {Brundin, Lena and Petersén, Åsa and Björkqvist, Maria and Träskman Bendz, Lil},
  issn         = {1573-2517},
  keyword      = {Orexin,Movement,Depression,Suicide,Behaviour},
  language     = {eng},
  number       = {1-3},
  pages        = {259--263},
  publisher    = {Elsevier},
  series       = {Journal of Affective Disorders},
  title        = {Orexin and psychiatric symptoms in suicide attempters.},
  url          = {http://dx.doi.org/10.1016/j.jad.2006.10.019},
  volume       = {100},
  year         = {2007},
}