Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Cord blood islet autoantibodies are related to stress in the mother during pregnancy.

Lernmark, Barbro LU ; Lynch, Kristian LU ; Lernmark, Åke LU orcid and Study Group, DiPiS (2006) In Annals of the New York Academy of Sciences 1079(1079). p.345-349
Abstract
A 2-month psychological questionnaire concerning pregnancy was answered by 20,920 nondiabetic mothers of singletons. Retrospective analysis showed increased levels of islet autoantibodies (1A) in 290 (1.4%) newborns. High IA levels in the child's cord blood correlated strongly with IA levels in the mother (GADA r = 0.91, P < 0.0001; IA-2A r = 0.75, P = 0.0001). High IA levels were found in newborns whose mothers during pregnancy had been more worried than usual (P = 0.04), had worried that the child would be sick (P = 0.01) or not survive (P = 0.002), or had experienced serious life events, like "serious accident in the family" (P < 0.0001) or "experienced violence" (P = 0.02). Associations with increased worries by the mother... (More)
A 2-month psychological questionnaire concerning pregnancy was answered by 20,920 nondiabetic mothers of singletons. Retrospective analysis showed increased levels of islet autoantibodies (1A) in 290 (1.4%) newborns. High IA levels in the child's cord blood correlated strongly with IA levels in the mother (GADA r = 0.91, P < 0.0001; IA-2A r = 0.75, P = 0.0001). High IA levels were found in newborns whose mothers during pregnancy had been more worried than usual (P = 0.04), had worried that the child would be sick (P = 0.01) or not survive (P = 0.002), or had experienced serious life events, like "serious accident in the family" (P < 0.0001) or "experienced violence" (P = 0.02). Associations with increased worries by the mother remained in newborns with high type 1 diabetes mellitus (T1DM)-human leukocyte antigen (HLA) risk, but not in non-HLA risk children. ne prospective follow-up of these children will determine the importance of this early 1A for postnatal islet autoimmunity, type I diabetes, or both. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
autoantibodies, stress, type 1 diabetes
in
Annals of the New York Academy of Sciences
volume
1079
issue
1079
pages
345 - 349
publisher
Wiley-Blackwell
external identifiers
  • wos:000243126100053
  • scopus:33845705293
  • pmid:17130577
ISSN
0077-8923
DOI
10.1196/annals.1375.053
language
English
LU publication?
yes
id
ad34e32b-27ce-4c20-bcfb-a4675bfcb599 (old id 164345)
date added to LUP
2016-04-01 15:42:15
date last changed
2022-01-28 06:38:32
@article{ad34e32b-27ce-4c20-bcfb-a4675bfcb599,
  abstract     = {{A 2-month psychological questionnaire concerning pregnancy was answered by 20,920 nondiabetic mothers of singletons. Retrospective analysis showed increased levels of islet autoantibodies (1A) in 290 (1.4%) newborns. High IA levels in the child's cord blood correlated strongly with IA levels in the mother (GADA r = 0.91, P &lt; 0.0001; IA-2A r = 0.75, P = 0.0001). High IA levels were found in newborns whose mothers during pregnancy had been more worried than usual (P = 0.04), had worried that the child would be sick (P = 0.01) or not survive (P = 0.002), or had experienced serious life events, like "serious accident in the family" (P &lt; 0.0001) or "experienced violence" (P = 0.02). Associations with increased worries by the mother remained in newborns with high type 1 diabetes mellitus (T1DM)-human leukocyte antigen (HLA) risk, but not in non-HLA risk children. ne prospective follow-up of these children will determine the importance of this early 1A for postnatal islet autoimmunity, type I diabetes, or both.}},
  author       = {{Lernmark, Barbro and Lynch, Kristian and Lernmark, Åke and Study Group, DiPiS}},
  issn         = {{0077-8923}},
  keywords     = {{autoantibodies; stress; type 1 diabetes}},
  language     = {{eng}},
  number       = {{1079}},
  pages        = {{345--349}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Annals of the New York Academy of Sciences}},
  title        = {{Cord blood islet autoantibodies are related to stress in the mother during pregnancy.}},
  url          = {{http://dx.doi.org/10.1196/annals.1375.053}},
  doi          = {{10.1196/annals.1375.053}},
  volume       = {{1079}},
  year         = {{2006}},
}