Allelic variation in a fatty-acyl reductase gene causes divergence in moth sex pheromones
Lassance, Jean-Marc LU ; Groot, Astrid T ; Liénard, Marjorie LU
; Antony, Binu
LU
; Borgwardt, Christin
; Andersson, Fredrik
; Hedenström, Erik
; Heckel, David G
and Löfstedt, Christer
LU
(2010)
In Nature
466(7305).
p.486-489
- Abstract
- Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta: Lepidoptera), females emit a species-specific pheromone blend that attracts males over long distances. The European corn borer, [i)Ostrinia nubilalis[/i], consists of two sex pheromone races, Z and E, that use different ratios of the cis and trans isomers of acetate pheromone components. This subtle difference leads to strong reproductive isolation in the field between the two races, which could represent a... (More)
- Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta: Lepidoptera), females emit a species-specific pheromone blend that attracts males over long distances. The European corn borer, [i)Ostrinia nubilalis[/i], consists of two sex pheromone races, Z and E, that use different ratios of the cis and trans isomers of acetate pheromone components. This subtle difference leads to strong reproductive isolation in the field between the two races, which could represent a first step in speciation. Female sex pheromone production and male behavioural response are under the control of different major genes, but the identity of these genes is unknown. Here we show that allelic variation in a fatty-acyl reductase gene essential for pheromone biosynthesis accounts for the phenotypic variation in female pheromone production, leading to race-specific signals. Both the cis and trans isomers of the pheromone precursors are produced by both races, but the precursors are differentially reduced to yield opposite ratios in the final pheromone blend as a result of the substrate specificity of the enzymes encoded by the Z and E alleles. This is the first functional characterization of a gene contributing to intraspecific behavioural reproductive isolation in moths, highlighting the importance of evolutionary diversification in a lepidopteran-specific family of reductases. Accumulation of substitutions in the coding region of a single biosynthetic enzyme can produce pheromone differences resulting in reproductive isolation, with speciation as a potential end result. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1645389
- author
- Lassance, Jean-Marc
LU
; Groot, Astrid T
; Liénard, Marjorie
LU
; Antony, Binu
LU
; Borgwardt, Christin
; Andersson, Fredrik
; Hedenström, Erik
; Heckel, David G
and Löfstedt, Christer
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature
- volume
- 466
- issue
- 7305
- pages
- 486 - 489
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000280141200035
- scopus:77954951585
- ISSN
- 0028-0836
- DOI
- 10.1038/nature09058
- project
- The pheromone brewery
- Evolutionary mechanisms of pheromone divergence in Lepidoptera
- language
- English
- LU publication?
- yes
- id
- bbe3c8c6-f898-452b-8afb-181bfb294d24 (old id 1645389)
- date added to LUP
- 2016-04-01 10:48:07
- date last changed
- 2022-04-20 06:19:43
@article{bbe3c8c6-f898-452b-8afb-181bfb294d24,
abstract = {{Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta: Lepidoptera), females emit a species-specific pheromone blend that attracts males over long distances. The European corn borer, [i)Ostrinia nubilalis[/i], consists of two sex pheromone races, <i>Z</i> and <i>E</i>, that use different ratios of the cis and trans isomers of acetate pheromone components. This subtle difference leads to strong reproductive isolation in the field between the two races, which could represent a first step in speciation. Female sex pheromone production and male behavioural response are under the control of different major genes, but the identity of these genes is unknown. Here we show that allelic variation in a fatty-acyl reductase gene essential for pheromone biosynthesis accounts for the phenotypic variation in female pheromone production, leading to race-specific signals. Both the cis and trans isomers of the pheromone precursors are produced by both races, but the precursors are differentially reduced to yield opposite ratios in the final pheromone blend as a result of the substrate specificity of the enzymes encoded by the Z and E alleles. This is the first functional characterization of a gene contributing to intraspecific behavioural reproductive isolation in moths, highlighting the importance of evolutionary diversification in a lepidopteran-specific family of reductases. Accumulation of substitutions in the coding region of a single biosynthetic enzyme can produce pheromone differences resulting in reproductive isolation, with speciation as a potential end result.}},
author = {{Lassance, Jean-Marc and Groot, Astrid T and Liénard, Marjorie and Antony, Binu and Borgwardt, Christin and Andersson, Fredrik and Hedenström, Erik and Heckel, David G and Löfstedt, Christer}},
issn = {{0028-0836}},
language = {{eng}},
number = {{7305}},
pages = {{486--489}},
publisher = {{Nature Publishing Group}},
series = {{Nature}},
title = {{Allelic variation in a fatty-acyl reductase gene causes divergence in moth sex pheromones}},
url = {{http://dx.doi.org/10.1038/nature09058}},
doi = {{10.1038/nature09058}},
volume = {{466}},
year = {{2010}},
}