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Menorrhagia and minor bleeding symptoms in women on oral anticoagulation.

Själander, Anders; Friberg, Britt LU ; Svensson, Peter LU ; Stigendal, Lennart and Lethagen, Stefan LU (2007) In Journal of Thrombosis and Thrombolysis 24(1). p.39-41
Abstract
Background Oral anticoagulation (OA) is a common treatment with a known risk of fatal or major bleeding, but also minor bleeding symptoms and menorrhagia can cause substantial discomfort and necessitate medical or surgical interventions. The extent of these side effects is however not previously reported. The objective of this study is to assess the frequency of minor bleeding symptoms and menorrhagia attributed to OA treatment.

Methods Ninety fertile women between 15 and 49 years-of-age on OA treatment completed an inquiry at the anticoagulation clinics of Malmö, Lund and Gothenburg, Sweden.

Results The frequency of minor bleeding symptoms was significantly increased during OA treatment (P < 0.05) except for... (More)
Background Oral anticoagulation (OA) is a common treatment with a known risk of fatal or major bleeding, but also minor bleeding symptoms and menorrhagia can cause substantial discomfort and necessitate medical or surgical interventions. The extent of these side effects is however not previously reported. The objective of this study is to assess the frequency of minor bleeding symptoms and menorrhagia attributed to OA treatment.

Methods Ninety fertile women between 15 and 49 years-of-age on OA treatment completed an inquiry at the anticoagulation clinics of Malmö, Lund and Gothenburg, Sweden.

Results The frequency of minor bleeding symptoms was significantly increased during OA treatment (P < 0.05) except for hematuria. The incidence of bleeding after tooth extraction (>3 h) increased from 3.0 to 45.2%, easy bruising 17.8–75.6%, epistaxis 11.1–23.6%, gingival bleeding 22.2–48.3% and hematuria 10.0–15.6% (Table 1). Hematemesis was reported in 5.6% prior to as compared to 14.4% during OA treatment, blood in the feces in 8.9 and 18.9%, respectively. Mean duration of menses increased from 5.6 to 6.1 days (P < 0.01) and reported menorrhagia from 44.2 to 70.8% (P < 0.001). Eighteen percent were treated for menorrhagia before and 29.9% during OA treatment (P < 0.01).

Conclusions OA treatment is known to confer increased risk of fatal or major bleeding. This study shows that fertile women on OA also experience significantly increased minor bleeding symptoms including menorrhagia that may considerably impair quality of life. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Minor bleeding symptoms, Menorrhagia, Warfarin, Oral anticoagulation
in
Journal of Thrombosis and Thrombolysis
volume
24
issue
1
pages
39 - 41
publisher
Springer
external identifiers
  • wos:000246585500006
  • scopus:34249679559
ISSN
1573-742X
DOI
10.1007/s11239-006-0003-7
language
English
LU publication?
yes
id
e85d657d-cc53-4a28-99e8-46df5635653e (old id 164581)
date added to LUP
2007-07-24 09:57:45
date last changed
2017-09-17 07:01:32
@article{e85d657d-cc53-4a28-99e8-46df5635653e,
  abstract     = {Background Oral anticoagulation (OA) is a common treatment with a known risk of fatal or major bleeding, but also minor bleeding symptoms and menorrhagia can cause substantial discomfort and necessitate medical or surgical interventions. The extent of these side effects is however not previously reported. The objective of this study is to assess the frequency of minor bleeding symptoms and menorrhagia attributed to OA treatment.<br/><br>
Methods Ninety fertile women between 15 and 49 years-of-age on OA treatment completed an inquiry at the anticoagulation clinics of Malmö, Lund and Gothenburg, Sweden.<br/><br>
Results The frequency of minor bleeding symptoms was significantly increased during OA treatment (P &lt; 0.05) except for hematuria. The incidence of bleeding after tooth extraction (&gt;3 h) increased from 3.0 to 45.2%, easy bruising 17.8–75.6%, epistaxis 11.1–23.6%, gingival bleeding 22.2–48.3% and hematuria 10.0–15.6% (Table 1). Hematemesis was reported in 5.6% prior to as compared to 14.4% during OA treatment, blood in the feces in 8.9 and 18.9%, respectively. Mean duration of menses increased from 5.6 to 6.1 days (P &lt; 0.01) and reported menorrhagia from 44.2 to 70.8% (P &lt; 0.001). Eighteen percent were treated for menorrhagia before and 29.9% during OA treatment (P &lt; 0.01).<br/><br>
Conclusions OA treatment is known to confer increased risk of fatal or major bleeding. This study shows that fertile women on OA also experience significantly increased minor bleeding symptoms including menorrhagia that may considerably impair quality of life.},
  author       = {Själander, Anders and Friberg, Britt and Svensson, Peter and Stigendal, Lennart and Lethagen, Stefan},
  issn         = {1573-742X},
  keyword      = {Minor bleeding symptoms,Menorrhagia,Warfarin,Oral anticoagulation},
  language     = {eng},
  number       = {1},
  pages        = {39--41},
  publisher    = {Springer},
  series       = {Journal of Thrombosis and Thrombolysis},
  title        = {Menorrhagia and minor bleeding symptoms in women on oral anticoagulation.},
  url          = {http://dx.doi.org/10.1007/s11239-006-0003-7},
  volume       = {24},
  year         = {2007},
}