Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.
(2007) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 31(7). p.995-1001- Abstract
- The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, but declines in mature populations. The erythroid lineage appears as a special case, as TRIM22 expression shows an extreme decrease during late erythroid maturation and is completely undetectable in nucleated erythroid populations in contrast to other lineages. In conclusion, our data Could suggest lineage-specific roles for TRIM22 during... (More)
- The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, but declines in mature populations. The erythroid lineage appears as a special case, as TRIM22 expression shows an extreme decrease during late erythroid maturation and is completely undetectable in nucleated erythroid populations in contrast to other lineages. In conclusion, our data Could suggest lineage-specific roles for TRIM22 during haematopoietic differentiation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/164611
- author
- Obad, Susanna LU ; Olofsson, Tor LU ; Mechti, Nadir ; Gullberg, Urban LU and Drott, Kristina LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- IFN, differentiation, p53, haematopoiesis, TRIM22, Staf50
- in
- Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
- volume
- 31
- issue
- 7
- pages
- 995 - 1001
- publisher
- Elsevier
- external identifiers
-
- wos:000247764300016
- scopus:34249817109
- pmid:17257675
- ISSN
- 1873-5835
- DOI
- 10.1016/j.leukres.2006.12.012
- language
- English
- LU publication?
- yes
- id
- b396e6c7-b741-4943-b6b5-0c64a6dc7244 (old id 164611)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17257675&dopt=Abstract
- date added to LUP
- 2016-04-01 12:04:43
- date last changed
- 2024-10-08 20:53:13
@article{b396e6c7-b741-4943-b6b5-0c64a6dc7244, abstract = {{The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, but declines in mature populations. The erythroid lineage appears as a special case, as TRIM22 expression shows an extreme decrease during late erythroid maturation and is completely undetectable in nucleated erythroid populations in contrast to other lineages. In conclusion, our data Could suggest lineage-specific roles for TRIM22 during haematopoietic differentiation.}}, author = {{Obad, Susanna and Olofsson, Tor and Mechti, Nadir and Gullberg, Urban and Drott, Kristina}}, issn = {{1873-5835}}, keywords = {{IFN; differentiation; p53; haematopoiesis; TRIM22; Staf50}}, language = {{eng}}, number = {{7}}, pages = {{995--1001}}, publisher = {{Elsevier}}, series = {{Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis}}, title = {{Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.}}, url = {{http://dx.doi.org/10.1016/j.leukres.2006.12.012}}, doi = {{10.1016/j.leukres.2006.12.012}}, volume = {{31}}, year = {{2007}}, }