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Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.

Obad, Susanna LU ; Olofsson, Tor LU ; Mechti, Nadir; Gullberg, Urban LU and Drott, Kristina LU (2007) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 31(7). p.995-1001
Abstract
The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, but declines in mature populations. The erythroid lineage appears as a special case, as TRIM22 expression shows an extreme decrease during late erythroid maturation and is completely undetectable in nucleated erythroid populations in contrast to other lineages. In conclusion, our data Could suggest lineage-specific roles for TRIM22 during... (More)
The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, but declines in mature populations. The erythroid lineage appears as a special case, as TRIM22 expression shows an extreme decrease during late erythroid maturation and is completely undetectable in nucleated erythroid populations in contrast to other lineages. In conclusion, our data Could suggest lineage-specific roles for TRIM22 during haematopoietic differentiation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IFN, differentiation, p53, haematopoiesis, TRIM22, Staf50
in
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
volume
31
issue
7
pages
995 - 1001
publisher
Elsevier
external identifiers
  • wos:000247764300016
  • scopus:34249817109
ISSN
1873-5835
DOI
10.1016/j.leukres.2006.12.012
language
English
LU publication?
yes
id
b396e6c7-b741-4943-b6b5-0c64a6dc7244 (old id 164611)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17257675&dopt=Abstract
date added to LUP
2007-07-09 13:23:03
date last changed
2017-07-09 03:38:52
@article{b396e6c7-b741-4943-b6b5-0c64a6dc7244,
  abstract     = {The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, but declines in mature populations. The erythroid lineage appears as a special case, as TRIM22 expression shows an extreme decrease during late erythroid maturation and is completely undetectable in nucleated erythroid populations in contrast to other lineages. In conclusion, our data Could suggest lineage-specific roles for TRIM22 during haematopoietic differentiation.},
  author       = {Obad, Susanna and Olofsson, Tor and Mechti, Nadir and Gullberg, Urban and Drott, Kristina},
  issn         = {1873-5835},
  keyword      = {IFN,differentiation,p53,haematopoiesis,TRIM22,Staf50},
  language     = {eng},
  number       = {7},
  pages        = {995--1001},
  publisher    = {Elsevier},
  series       = {Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis},
  title        = {Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.},
  url          = {http://dx.doi.org/10.1016/j.leukres.2006.12.012},
  volume       = {31},
  year         = {2007},
}