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The impact of large tidal volume ventilation on the absorption of inhaled insulin in rabbits.

Petersen, Astrid H; Laursen, Torben; Ahrén, Bo LU ; Pieber, Thomas R; Clauson, Per and Wollmer, Per LU (2007) In European Journal of Pharmaceutical Sciences 30(3-4). p.351-357
Abstract
Previous studies have shown that ventilation patterns affect absorption of inhaled compounds. Thus, the aim of this study was to investigate the effect of large tidal volume ventilation (LTVV) on the absorption of inhaled insulin in rabbits. Mechanically ventilated rabbits were given human insulin via a nebuliser system, and plasma insulin was measured for the following 120 min. Ventilation was adjusted to (1) normal tidal volume ventilation (NTVV) for the entire period after dosing (NTVV group), to (2) LTVV for the entire period after dosing (LTVV group), to (3) NTVV except for 15 min LTVV immediately after dosing (Early LTVV group), or to (4) NTVV except for 15 min LTVV starting at 60 min after dosing (late LTVV group). Insulin... (More)
Previous studies have shown that ventilation patterns affect absorption of inhaled compounds. Thus, the aim of this study was to investigate the effect of large tidal volume ventilation (LTVV) on the absorption of inhaled insulin in rabbits. Mechanically ventilated rabbits were given human insulin via a nebuliser system, and plasma insulin was measured for the following 120 min. Ventilation was adjusted to (1) normal tidal volume ventilation (NTVV) for the entire period after dosing (NTVV group), to (2) LTVV for the entire period after dosing (LTVV group), to (3) NTVV except for 15 min LTVV immediately after dosing (Early LTVV group), or to (4) NTVV except for 15 min LTVV starting at 60 min after dosing (late LTVV group). Insulin absorption (AUC(ins(0-120min))) was increased by 149% for the LTVV group compared to NTVV group (p < 0.01) with increased maximal insulin concentration (106%, p = 0.03). The Early LTVV group showed a changed absorption profile. For the late LTVV group an increase in insulin levels was observed after the LTVV period (not significant compared to the NTVV group). These data could potentially have implications for patients using inhaled insulin in situations where a change in breathing pattern is seen, such as exercise. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lung, insulin, administration, inhalation, animals, rabbits, pharmacokinetics, absorption
in
European Journal of Pharmaceutical Sciences
volume
30
issue
3-4
pages
351 - 357
publisher
Elsevier
external identifiers
  • wos:000245143100019
  • scopus:33847233665
ISSN
1879-0720
DOI
10.1016/j.ejps.2006.12.002
language
English
LU publication?
yes
id
93eb69ce-a507-41b0-a239-fe78af30dd46 (old id 164728)
date added to LUP
2007-07-10 11:26:49
date last changed
2017-01-01 04:36:56
@article{93eb69ce-a507-41b0-a239-fe78af30dd46,
  abstract     = {Previous studies have shown that ventilation patterns affect absorption of inhaled compounds. Thus, the aim of this study was to investigate the effect of large tidal volume ventilation (LTVV) on the absorption of inhaled insulin in rabbits. Mechanically ventilated rabbits were given human insulin via a nebuliser system, and plasma insulin was measured for the following 120 min. Ventilation was adjusted to (1) normal tidal volume ventilation (NTVV) for the entire period after dosing (NTVV group), to (2) LTVV for the entire period after dosing (LTVV group), to (3) NTVV except for 15 min LTVV immediately after dosing (Early LTVV group), or to (4) NTVV except for 15 min LTVV starting at 60 min after dosing (late LTVV group). Insulin absorption (AUC(ins(0-120min))) was increased by 149% for the LTVV group compared to NTVV group (p &lt; 0.01) with increased maximal insulin concentration (106%, p = 0.03). The Early LTVV group showed a changed absorption profile. For the late LTVV group an increase in insulin levels was observed after the LTVV period (not significant compared to the NTVV group). These data could potentially have implications for patients using inhaled insulin in situations where a change in breathing pattern is seen, such as exercise.},
  author       = {Petersen, Astrid H and Laursen, Torben and Ahrén, Bo and Pieber, Thomas R and Clauson, Per and Wollmer, Per},
  issn         = {1879-0720},
  keyword      = {lung,insulin,administration,inhalation,animals,rabbits,pharmacokinetics,absorption},
  language     = {eng},
  number       = {3-4},
  pages        = {351--357},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmaceutical Sciences},
  title        = {The impact of large tidal volume ventilation on the absorption of inhaled insulin in rabbits.},
  url          = {http://dx.doi.org/10.1016/j.ejps.2006.12.002},
  volume       = {30},
  year         = {2007},
}