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Endogenous androgens and risk of epithelial ovarian cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC).

Rinaldi, Sabina; Dossus, Laure; Lukanova, Annekatrin; Peeters, Petra H M; Allen, Naomi E; Key, Timothy; Bingham, Sheila; Khaw, Kay-Tee; Trichopoulos, Dimitrios and Trichopoulou, Antonia, et al. (2007) In Cancer Epidemiology Biomarkers & Prevention 16(1). p.23-29
Abstract
Few epidemiologic studies have examined the hypothesis that circulating androgens are involved in the development of ovarian cancer. We investigated the association between prediagnostic serum levels of androgens and sex hormone–binding globulin (SHBG) and ovarian cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One hundred and ninety-two ovarian cancer cases and 346 matched controls not using exogenous hormones at baseline blood donation were eligible for the study. Serum levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, and SHBG were measured by direct immunoassays. Free testosterone (fT) was calculated according to mass action laws.... (More)
Few epidemiologic studies have examined the hypothesis that circulating androgens are involved in the development of ovarian cancer. We investigated the association between prediagnostic serum levels of androgens and sex hormone–binding globulin (SHBG) and ovarian cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One hundred and ninety-two ovarian cancer cases and 346 matched controls not using exogenous hormones at baseline blood donation were eligible for the study. Serum levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, and SHBG were measured by direct immunoassays. Free testosterone (fT) was calculated according to mass action laws. Multivariate conditional logistic regression was used to estimate odds ratios adjusted for possible confounders. Overall, there was no association between serum concentrations of androgens or SHBG and ovarian cancer risk. In postmenopausal women, fT concentrations were inversely related to risk [highest versus lowest tertile odds ratio 0.45 (0.24-0.86); Ptrend = 0.01]. Among women diagnosed before the age of 55 years, there was a negative association with SHBG and a positive association with fT and ovarian cancer risk, although these associations were not statistically significant. The present study suggests that circulating androgens and SHBG levels are not strongly associated with ovarian cancer risk, although levels of fT may be associated with an increased risk among women diagnosed at relatively young age. The heterogeneity of results on the associations of fT with ovarian cancer risk in postmenopausal women deserves further investigation. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
16
issue
1
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23 - 29
publisher
American Association for Cancer Research
external identifiers
  • wos:000243550100005
  • scopus:33846577457
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-06-0755
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English
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63dd588d-464f-41bd-ac89-545ef369818a (old id 164918)
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2007-07-30 12:25:48
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@article{63dd588d-464f-41bd-ac89-545ef369818a,
  abstract     = {Few epidemiologic studies have examined the hypothesis that circulating androgens are involved in the development of ovarian cancer. We investigated the association between prediagnostic serum levels of androgens and sex hormone–binding globulin (SHBG) and ovarian cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One hundred and ninety-two ovarian cancer cases and 346 matched controls not using exogenous hormones at baseline blood donation were eligible for the study. Serum levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, and SHBG were measured by direct immunoassays. Free testosterone (fT) was calculated according to mass action laws. Multivariate conditional logistic regression was used to estimate odds ratios adjusted for possible confounders. Overall, there was no association between serum concentrations of androgens or SHBG and ovarian cancer risk. In postmenopausal women, fT concentrations were inversely related to risk [highest versus lowest tertile odds ratio 0.45 (0.24-0.86); Ptrend = 0.01]. Among women diagnosed before the age of 55 years, there was a negative association with SHBG and a positive association with fT and ovarian cancer risk, although these associations were not statistically significant. The present study suggests that circulating androgens and SHBG levels are not strongly associated with ovarian cancer risk, although levels of fT may be associated with an increased risk among women diagnosed at relatively young age. The heterogeneity of results on the associations of fT with ovarian cancer risk in postmenopausal women deserves further investigation.},
  author       = {Rinaldi, Sabina and Dossus, Laure and Lukanova, Annekatrin and Peeters, Petra H M and Allen, Naomi E and Key, Timothy and Bingham, Sheila and Khaw, Kay-Tee and Trichopoulos, Dimitrios and Trichopoulou, Antonia and Oikonomou, Eleni and Pera, Guillem and Larrañaga, Nerea and Martinez-Garcia, Carmen and Ardanaz, Eva and Quirós, J Ramón and Tormo, María-José and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Chang-Claude, Jenny and Linseisen, Jakob and Schulz, Mandy and Boeing, Heiner and van Gils, Carla H and Bueno-de-Mesquita, Bas H and Pala, Valeria and Palli, Domenico and Panico, Salvatore and Tumino, Rosario and Vineis, Paolo and Clavel-Chapelon, Françoise and Mesrine, Sylvie and Boutron-Ruault, Marie-Christine and Lundin, Eva and Agren, Asa and Berglund, Göran and Manjer, Jonas and Kumle, Merethe and Lund, Eiliv and Slimani, Nadia and Saracci, Rodolfo and Riboli, Elio and Kaaks, Rudolf},
  issn         = {1538-7755},
  language     = {eng},
  number       = {1},
  pages        = {23--29},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Endogenous androgens and risk of epithelial ovarian cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC).},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-06-0755},
  volume       = {16},
  year         = {2007},
}