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Efficacy of Bioactive Polypeptides on Bleeding and Intra-Abdominal Adhesions.

Tingstedt, Bobby LU ; Nehéz, Laszlo LU ; Lindman, Björn LU and Andersson, Roland LU (2007) In European Surgical Research 39(1). p.35-40
Abstract
Background: Perioperative bleeding and postoperative adhesions are two problems encountered in abdominal surgery. Commercial products are available that decrease both bleeding and development of abdominal adhesions, but no products are effective in both situations. The combination of differently charged bioactive polypeptides, administered intraperitoneally, has previously been shown effective in decreasing postoperative adhesions. The present study is a pilot examination of the effects on perioperative bleeding and postoperative adhesions, applying the polypeptide concept. Methods: Standardized wounds in the liver and spleen were induced in 52 NMRI mice. The amounts of bleeding and postoperative adhesions were measured after 1 and 7 days,... (More)
Background: Perioperative bleeding and postoperative adhesions are two problems encountered in abdominal surgery. Commercial products are available that decrease both bleeding and development of abdominal adhesions, but no products are effective in both situations. The combination of differently charged bioactive polypeptides, administered intraperitoneally, has previously been shown effective in decreasing postoperative adhesions. The present study is a pilot examination of the effects on perioperative bleeding and postoperative adhesions, applying the polypeptide concept. Methods: Standardized wounds in the liver and spleen were induced in 52 NMRI mice. The amounts of bleeding and postoperative adhesions were measured after 1 and 7 days, respectively. Separate animals were examined after 8 weeks for long-term healing of the parenchymal wounds. Results: Both parenchymal bleeding and the extent of adhesions significantly decreased (p=0.001 and p=0.029, respectively) as compared to controls. Histology after 8 weeks showed no clear signs of impaired or altered healing. Conclusion: Intraperitoneal administration of differently charged polypeptides significantly decreased postoperative bleeding and postoperative adhesions. Bioactive polypeptides appear promising in the promotion of peritoneal healing and merits further studies. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
polypeptides, parenchymal bleeding, adhesions, collagen ratio
in
European Surgical Research
volume
39
issue
1
pages
35 - 40
publisher
Karger
external identifiers
  • wos:000244746300007
  • scopus:33947273131
ISSN
0014-312X
DOI
10.1159/000098438
language
English
LU publication?
yes
id
7b5efae7-f48f-4007-ab62-a243041368bd (old id 165018)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17213725&dopt=Abstract
date added to LUP
2007-07-24 11:24:55
date last changed
2017-01-01 04:22:32
@article{7b5efae7-f48f-4007-ab62-a243041368bd,
  abstract     = {Background: Perioperative bleeding and postoperative adhesions are two problems encountered in abdominal surgery. Commercial products are available that decrease both bleeding and development of abdominal adhesions, but no products are effective in both situations. The combination of differently charged bioactive polypeptides, administered intraperitoneally, has previously been shown effective in decreasing postoperative adhesions. The present study is a pilot examination of the effects on perioperative bleeding and postoperative adhesions, applying the polypeptide concept. Methods: Standardized wounds in the liver and spleen were induced in 52 NMRI mice. The amounts of bleeding and postoperative adhesions were measured after 1 and 7 days, respectively. Separate animals were examined after 8 weeks for long-term healing of the parenchymal wounds. Results: Both parenchymal bleeding and the extent of adhesions significantly decreased (p=0.001 and p=0.029, respectively) as compared to controls. Histology after 8 weeks showed no clear signs of impaired or altered healing. Conclusion: Intraperitoneal administration of differently charged polypeptides significantly decreased postoperative bleeding and postoperative adhesions. Bioactive polypeptides appear promising in the promotion of peritoneal healing and merits further studies.},
  author       = {Tingstedt, Bobby and Nehéz, Laszlo and Lindman, Björn and Andersson, Roland},
  issn         = {0014-312X},
  keyword      = {polypeptides,parenchymal bleeding,adhesions,collagen ratio},
  language     = {eng},
  number       = {1},
  pages        = {35--40},
  publisher    = {Karger},
  series       = {European Surgical Research},
  title        = {Efficacy of Bioactive Polypeptides on Bleeding and Intra-Abdominal Adhesions.},
  url          = {http://dx.doi.org/10.1159/000098438},
  volume       = {39},
  year         = {2007},
}