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Plasma proteome profiling reveals biomarker patterns associated with prognosis and therapy selection in glioblastoma multiforme patients

Carlsson, Anders LU ; Persson, Oscar LU ; Ingvarsson, Johan LU ; Widegren, Bengt LU ; Salford, Leif LU ; Borrebaeck, Carl LU and Wingren, Christer LU (2010) In Proteomics Clinical Applications 4(6-7). p.591-602
Abstract
Purpose: Glioblastoma multiforme (GBM) is a frequent and aggressive type of primary brain tumor with a heterogeneous origin. GBM is highly therapy resistant and carries a dismal prognosis for the patient. The purpose of this discovery study was to define candidate plasma biomarker signatures for improved classification and novel means for selecting patients for refined individualized therapy. Experimental design: Here, we have for the first time investigated the applicability of large-scale recombinant antibody-based microarrays, targeting mainly immunoregulatory analytes, for sensitive and selective plasma protein profiling of GBM patients undergoing immunotherapy with autologous IFN-gamma transfected glioma cells Results: This... (More)
Purpose: Glioblastoma multiforme (GBM) is a frequent and aggressive type of primary brain tumor with a heterogeneous origin. GBM is highly therapy resistant and carries a dismal prognosis for the patient. The purpose of this discovery study was to define candidate plasma biomarker signatures for improved classification and novel means for selecting patients for refined individualized therapy. Experimental design: Here, we have for the first time investigated the applicability of large-scale recombinant antibody-based microarrays, targeting mainly immunoregulatory analytes, for sensitive and selective plasma protein profiling of GBM patients undergoing immunotherapy with autologous IFN-gamma transfected glioma cells Results: This proof-of-concept study showed that candidate plasma protein signatures associated with GBM were outlined that could be used for GBM classification, monitoring the effects of the immunotherapy as well as for stratifying patients according to the beneficial effect of the adopted immunotherapy Further, central key cytokines that could be utilized for optimization and/or refinement of the immunotherapeutic regime were indicated. Conclusions and clinical relevance: Candidate plasma proteins signatures associated with GBM was outlined, that could be used for GBM classification and for pre-operatively stratifying patients according to the beneficial effect of the adopted immunotherapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Plasma protein profiling, Glioblastoma multiforme, Oncoproteomics, Recombinant antibody microarrays
in
Proteomics Clinical Applications
volume
4
issue
6-7
pages
591 - 602
publisher
John Wiley & Sons
external identifiers
  • wos:000280434200003
  • pmid:21137077
  • scopus:77955823113
ISSN
1862-8354
DOI
10.1002/prca.200900173
language
English
LU publication?
yes
id
a0a77143-d6ce-4561-8d75-4ae0830d0bbe (old id 1653699)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21137077?dopt=Abstract
date added to LUP
2010-08-26 09:50:59
date last changed
2018-05-29 11:06:33
@article{a0a77143-d6ce-4561-8d75-4ae0830d0bbe,
  abstract     = {Purpose: Glioblastoma multiforme (GBM) is a frequent and aggressive type of primary brain tumor with a heterogeneous origin. GBM is highly therapy resistant and carries a dismal prognosis for the patient. The purpose of this discovery study was to define candidate plasma biomarker signatures for improved classification and novel means for selecting patients for refined individualized therapy. Experimental design: Here, we have for the first time investigated the applicability of large-scale recombinant antibody-based microarrays, targeting mainly immunoregulatory analytes, for sensitive and selective plasma protein profiling of GBM patients undergoing immunotherapy with autologous IFN-gamma transfected glioma cells Results: This proof-of-concept study showed that candidate plasma protein signatures associated with GBM were outlined that could be used for GBM classification, monitoring the effects of the immunotherapy as well as for stratifying patients according to the beneficial effect of the adopted immunotherapy Further, central key cytokines that could be utilized for optimization and/or refinement of the immunotherapeutic regime were indicated. Conclusions and clinical relevance: Candidate plasma proteins signatures associated with GBM was outlined, that could be used for GBM classification and for pre-operatively stratifying patients according to the beneficial effect of the adopted immunotherapy.},
  author       = {Carlsson, Anders and Persson, Oscar and Ingvarsson, Johan and Widegren, Bengt and Salford, Leif and Borrebaeck, Carl and Wingren, Christer},
  issn         = {1862-8354},
  keyword      = {Plasma protein profiling,Glioblastoma multiforme,Oncoproteomics,Recombinant antibody microarrays},
  language     = {eng},
  number       = {6-7},
  pages        = {591--602},
  publisher    = {John Wiley & Sons},
  series       = {Proteomics Clinical Applications},
  title        = {Plasma proteome profiling reveals biomarker patterns associated with prognosis and therapy selection in glioblastoma multiforme patients},
  url          = {http://dx.doi.org/10.1002/prca.200900173},
  volume       = {4},
  year         = {2010},
}